A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L.
Nigella sativa L. is one of the most extensively used traditional medicinal plants. This widely studied plant is known to display diverse pharmacological actions, including antimicrobial activities. Current literature has documented its multi-target mode of antimicrobial actions. N. sativa or its bi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2021
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| Online Access: | http://umpir.ump.edu.my/id/eprint/32657/1/A%20review%20of%20ethnobotany%20phytochemistry%20antimicrobial%20pharmacology.pdf |
| _version_ | 1825814080195133440 |
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| author | Hossain, Md. Sanower Sharfaraz, Ashik Dutta, Amit Ahsan, Asif Masud, Md. Anwarul Ahmed, Idris Adewale Goh, Bey Hing Urbi, Zannat Sarker, Md. Moklesur Rahman Ming, Long Chiau |
| author_facet | Hossain, Md. Sanower Sharfaraz, Ashik Dutta, Amit Ahsan, Asif Masud, Md. Anwarul Ahmed, Idris Adewale Goh, Bey Hing Urbi, Zannat Sarker, Md. Moklesur Rahman Ming, Long Chiau |
| author_sort | Hossain, Md. Sanower |
| collection | UMP |
| description | Nigella sativa L. is one of the most extensively used traditional medicinal plants. This widely studied plant is known to display diverse pharmacological actions, including antimicrobial activities. Current literature has documented its multi-target mode of antimicrobial actions. N. sativa or its bioactive compounds, such as thymoquinone, can induce oxidative stress, cell apoptosis (by producing reactive oxygen species), increase membrane permeability, inhibit efflux pumps, and impose strong biocidal actions. Despite its well-documented antimicrobial efficacy in the experimental model, to the best of our knowledge its antimicrobial mechanisms highlighting the multi-targeting properties have yet to be well discussed. Is N. sativa or thymoquinone a valuable lead compound for therapeutic development for infectious diseases? Are N. sativa’s bioactive compounds potential antimicrobial agents or able to overcome antimicrobial resistance? This review aims to discuss the antimicrobial pharmacology of N. sativa-based treatments. Additionally, it provides a holistic overview of the ethnobotany, ethnopharmacology, and phytochemistry of N. sativa. |
| first_indexed | 2024-03-06T12:53:32Z |
| format | Article |
| id | UMPir32657 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:53:32Z |
| publishDate | 2021 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | UMPir326572022-01-06T04:27:45Z http://umpir.ump.edu.my/id/eprint/32657/ A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. Hossain, Md. Sanower Sharfaraz, Ashik Dutta, Amit Ahsan, Asif Masud, Md. Anwarul Ahmed, Idris Adewale Goh, Bey Hing Urbi, Zannat Sarker, Md. Moklesur Rahman Ming, Long Chiau TP Chemical technology Nigella sativa L. is one of the most extensively used traditional medicinal plants. This widely studied plant is known to display diverse pharmacological actions, including antimicrobial activities. Current literature has documented its multi-target mode of antimicrobial actions. N. sativa or its bioactive compounds, such as thymoquinone, can induce oxidative stress, cell apoptosis (by producing reactive oxygen species), increase membrane permeability, inhibit efflux pumps, and impose strong biocidal actions. Despite its well-documented antimicrobial efficacy in the experimental model, to the best of our knowledge its antimicrobial mechanisms highlighting the multi-targeting properties have yet to be well discussed. Is N. sativa or thymoquinone a valuable lead compound for therapeutic development for infectious diseases? Are N. sativa’s bioactive compounds potential antimicrobial agents or able to overcome antimicrobial resistance? This review aims to discuss the antimicrobial pharmacology of N. sativa-based treatments. Additionally, it provides a holistic overview of the ethnobotany, ethnopharmacology, and phytochemistry of N. sativa. Elsevier Ltd 2021-11 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/32657/1/A%20review%20of%20ethnobotany%20phytochemistry%20antimicrobial%20pharmacology.pdf Hossain, Md. Sanower and Sharfaraz, Ashik and Dutta, Amit and Ahsan, Asif and Masud, Md. Anwarul and Ahmed, Idris Adewale and Goh, Bey Hing and Urbi, Zannat and Sarker, Md. Moklesur Rahman and Ming, Long Chiau (2021) A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. Biomedicine & Pharmacotherapy, 143 (112182). pp. 1-25. ISSN 0753-3322. (Published) https://doi.org/10.1016/j.biopha.2021.112182 https://doi.org/10.1016/j.biopha.2021.112182 |
| spellingShingle | TP Chemical technology Hossain, Md. Sanower Sharfaraz, Ashik Dutta, Amit Ahsan, Asif Masud, Md. Anwarul Ahmed, Idris Adewale Goh, Bey Hing Urbi, Zannat Sarker, Md. Moklesur Rahman Ming, Long Chiau A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. |
| title | A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. |
| title_full | A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. |
| title_fullStr | A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. |
| title_full_unstemmed | A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. |
| title_short | A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. |
| title_sort | review of ethnobotany phytochemistry antimicrobial pharmacology and toxicology of nigella sativa l |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/32657/1/A%20review%20of%20ethnobotany%20phytochemistry%20antimicrobial%20pharmacology.pdf |
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