Thymoquinone and its pharmacological perspective: A review
Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally and clinically used natural medicine. The diverse pharmacological properties of TQ have been identified including antimicrobial, antihistamine, antioxidant effects, immunomodulator, and anticancer activities....
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| Format: | Article |
| Language: | English |
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Elsevier
2021
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| Online Access: | http://umpir.ump.edu.my/id/eprint/32907/1/Pharmacological%20Research%20-%20TQ%20and%20Its%20Pharmacological%20Perspective%20A%20Review.pdf |
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| author | Tabassum, Shabana Norhayati, Rosli Arief Ichwan, Solachuddin Jauhari Mishrad, Puranjan |
| author_facet | Tabassum, Shabana Norhayati, Rosli Arief Ichwan, Solachuddin Jauhari Mishrad, Puranjan |
| author_sort | Tabassum, Shabana |
| collection | UMP |
| description | Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally and clinically used natural medicine. The diverse pharmacological properties of TQ have been identified including antimicrobial, antihistamine, antioxidant effects, immunomodulator, and anticancer activities. In this review, investigations regarding the effects of TQ in oxidative stress, immunomodulation, and various type of cancer have been reviewed based on the available relevant literature. TQ-based induction of the immune system by modulating different inflammatory mediators i.e., cytokines, leukins, interleukins, interferons, and other immune cells have been reviewed here. Several studies signified remarkable anticancer potentials of TQ depending upon its concentration and type of cancer cell. Conclusively, understanding pharmacological activities of TQ its molecular mechanism could help researchers to develop a potent analog of well-established chemotherapeutic drugs in clinical trials. |
| first_indexed | 2024-03-06T12:54:09Z |
| format | Article |
| id | UMPir32907 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:54:09Z |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | UMPir329072022-06-17T03:55:41Z http://umpir.ump.edu.my/id/eprint/32907/ Thymoquinone and its pharmacological perspective: A review Tabassum, Shabana Norhayati, Rosli Arief Ichwan, Solachuddin Jauhari Mishrad, Puranjan QA Mathematics RC Internal medicine Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally and clinically used natural medicine. The diverse pharmacological properties of TQ have been identified including antimicrobial, antihistamine, antioxidant effects, immunomodulator, and anticancer activities. In this review, investigations regarding the effects of TQ in oxidative stress, immunomodulation, and various type of cancer have been reviewed based on the available relevant literature. TQ-based induction of the immune system by modulating different inflammatory mediators i.e., cytokines, leukins, interleukins, interferons, and other immune cells have been reviewed here. Several studies signified remarkable anticancer potentials of TQ depending upon its concentration and type of cancer cell. Conclusively, understanding pharmacological activities of TQ its molecular mechanism could help researchers to develop a potent analog of well-established chemotherapeutic drugs in clinical trials. Elsevier 2021-12 Article PeerReviewed pdf en cc_by_nc_nd_4 http://umpir.ump.edu.my/id/eprint/32907/1/Pharmacological%20Research%20-%20TQ%20and%20Its%20Pharmacological%20Perspective%20A%20Review.pdf Tabassum, Shabana and Norhayati, Rosli and Arief Ichwan, Solachuddin Jauhari and Mishrad, Puranjan (2021) Thymoquinone and its pharmacological perspective: A review. Pharmacological Research - Modern Chinese Medicine, 1 (100020). pp. 1-10. ISSN 2667-1425. (Published) https://doi.org/10.1016/j.prmcm.2021.100020 https://doi.org/10.1016/j.prmcm.2021.100020 |
| spellingShingle | QA Mathematics RC Internal medicine Tabassum, Shabana Norhayati, Rosli Arief Ichwan, Solachuddin Jauhari Mishrad, Puranjan Thymoquinone and its pharmacological perspective: A review |
| title | Thymoquinone and its pharmacological perspective: A review |
| title_full | Thymoquinone and its pharmacological perspective: A review |
| title_fullStr | Thymoquinone and its pharmacological perspective: A review |
| title_full_unstemmed | Thymoquinone and its pharmacological perspective: A review |
| title_short | Thymoquinone and its pharmacological perspective: A review |
| title_sort | thymoquinone and its pharmacological perspective a review |
| topic | QA Mathematics RC Internal medicine |
| url | http://umpir.ump.edu.my/id/eprint/32907/1/Pharmacological%20Research%20-%20TQ%20and%20Its%20Pharmacological%20Perspective%20A%20Review.pdf |
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