Ibuprofen-loaded chitosan–lipid nanoconjugate hydrogel with gum arabic: Green synthesis, characterisation, in vitro kinetics mechanistic release study and PGE2 production test
Ibuprofen is a well-known non-steroidal anti-inflammatory (NSAID) medicine that is often used to treat inflammation in general. When given orally, it produces gastrointestinal issues which lead to lower patient compliance. Ibuprofen transdermal administration improves both patient compliance and the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2021
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| Online Access: | http://umpir.ump.edu.my/id/eprint/33080/1/Ibuprofen-loaded%20chitosan%E2%80%93lipid%20nanoconjugate%20hydrogel%20with%20gum%20arabic_Green%20synthesis.pdf |
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| author | Mahmood, Syed Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Hilles, Ayah Rebhi Alelwani, Walla Bannunah, Azzah M. Alshammari, Farhan Alheibshy, Fawaz |
| author_facet | Mahmood, Syed Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Hilles, Ayah Rebhi Alelwani, Walla Bannunah, Azzah M. Alshammari, Farhan Alheibshy, Fawaz |
| author_sort | Mahmood, Syed |
| collection | UMP |
| description | Ibuprofen is a well-known non-steroidal anti-inflammatory (NSAID) medicine that is often used to treat inflammation in general. When given orally, it produces gastrointestinal issues which lead to lower patient compliance. Ibuprofen transdermal administration improves both patient compliance and the efficacy of the drug. Nanoconjugation hydrogels were proposed as a controlled transdermal delivery tool for ibuprofen. Six formulations were prepared using different compositions including chitosan, lipids, gum arabic, and polyvinyl alcohol, through ionic interaction, maturation, and freeze–thaw methods. The formulations were characterised by size, drug conjugation efficiency, differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Further analysis of optimised hydrogels was performed, including X-ray diffraction (XRD), rheology, gel fraction and swelling ability, in vitro drug release, and in vitro macrophage prostaglandin E2 (PGE2 ) production testing. The effects of ibuprofen’s electrostatic interaction with a lipid or polymer on the physicochemical and dissolution characterisation of ibuprofen hydrogels were evaluated. The results showed that the S3 (with lipid conjugation) hydrogel provided higher conjugation efficiency and prolonged drug release compared with the S6 hydrogel. |
| first_indexed | 2024-03-06T12:54:29Z |
| format | Article |
| id | UMPir33080 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:54:29Z |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | UMPir330802022-07-22T05:26:08Z http://umpir.ump.edu.my/id/eprint/33080/ Ibuprofen-loaded chitosan–lipid nanoconjugate hydrogel with gum arabic: Green synthesis, characterisation, in vitro kinetics mechanistic release study and PGE2 production test Mahmood, Syed Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Hilles, Ayah Rebhi Alelwani, Walla Bannunah, Azzah M. Alshammari, Farhan Alheibshy, Fawaz TP Chemical technology Ibuprofen is a well-known non-steroidal anti-inflammatory (NSAID) medicine that is often used to treat inflammation in general. When given orally, it produces gastrointestinal issues which lead to lower patient compliance. Ibuprofen transdermal administration improves both patient compliance and the efficacy of the drug. Nanoconjugation hydrogels were proposed as a controlled transdermal delivery tool for ibuprofen. Six formulations were prepared using different compositions including chitosan, lipids, gum arabic, and polyvinyl alcohol, through ionic interaction, maturation, and freeze–thaw methods. The formulations were characterised by size, drug conjugation efficiency, differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Further analysis of optimised hydrogels was performed, including X-ray diffraction (XRD), rheology, gel fraction and swelling ability, in vitro drug release, and in vitro macrophage prostaglandin E2 (PGE2 ) production testing. The effects of ibuprofen’s electrostatic interaction with a lipid or polymer on the physicochemical and dissolution characterisation of ibuprofen hydrogels were evaluated. The results showed that the S3 (with lipid conjugation) hydrogel provided higher conjugation efficiency and prolonged drug release compared with the S6 hydrogel. MDPI 2021-12 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/33080/1/Ibuprofen-loaded%20chitosan%E2%80%93lipid%20nanoconjugate%20hydrogel%20with%20gum%20arabic_Green%20synthesis.pdf Mahmood, Syed and Almurisi, Samah Hamed and AL-japairai, Khater Ahmed Saeed and Hilles, Ayah Rebhi and Alelwani, Walla and Bannunah, Azzah M. and Alshammari, Farhan and Alheibshy, Fawaz (2021) Ibuprofen-loaded chitosan–lipid nanoconjugate hydrogel with gum arabic: Green synthesis, characterisation, in vitro kinetics mechanistic release study and PGE2 production test. Gels, 7 (4). pp. 1-19. ISSN 2310-2861. (Published) https://doi.org/10.3390/gels7040254 https://doi.org/10.3390/gels7040254 |
| spellingShingle | TP Chemical technology Mahmood, Syed Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Hilles, Ayah Rebhi Alelwani, Walla Bannunah, Azzah M. Alshammari, Farhan Alheibshy, Fawaz Ibuprofen-loaded chitosan–lipid nanoconjugate hydrogel with gum arabic: Green synthesis, characterisation, in vitro kinetics mechanistic release study and PGE2 production test |
| title | Ibuprofen-loaded chitosan–lipid nanoconjugate hydrogel with gum arabic: Green synthesis, characterisation, in vitro kinetics mechanistic release study and PGE2 production test |
| title_full | Ibuprofen-loaded chitosan–lipid nanoconjugate hydrogel with gum arabic: Green synthesis, characterisation, in vitro kinetics mechanistic release study and PGE2 production test |
| title_fullStr | Ibuprofen-loaded chitosan–lipid nanoconjugate hydrogel with gum arabic: Green synthesis, characterisation, in vitro kinetics mechanistic release study and PGE2 production test |
| title_full_unstemmed | Ibuprofen-loaded chitosan–lipid nanoconjugate hydrogel with gum arabic: Green synthesis, characterisation, in vitro kinetics mechanistic release study and PGE2 production test |
| title_short | Ibuprofen-loaded chitosan–lipid nanoconjugate hydrogel with gum arabic: Green synthesis, characterisation, in vitro kinetics mechanistic release study and PGE2 production test |
| title_sort | ibuprofen loaded chitosan lipid nanoconjugate hydrogel with gum arabic green synthesis characterisation in vitro kinetics mechanistic release study and pge2 production test |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/33080/1/Ibuprofen-loaded%20chitosan%E2%80%93lipid%20nanoconjugate%20hydrogel%20with%20gum%20arabic_Green%20synthesis.pdf |
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