Stability of paracetamol instant jelly for reconstitution: Impact of packaging, temperature and humidity
The stability of the medicinal product is a major concern in the pharmaceutical industry and health authorities, whose goal is to guarantee that drugs are delivered to patients without loss of therapeutic properties. This study aims to evaluate the effect of environmental conditions and packaging on...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2022
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| Online Access: | http://umpir.ump.edu.my/id/eprint/33579/1/Stability%20of%20paracetamol%20instant%20jelly%20for%20reconstitution%20_%20impact.pdf |
| _version_ | 1796994993671372800 |
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| author | Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Alshammari, Farhan Alheibshy, Fawaz Sammour, Rana M.F. Doolaanea, Abd Almonem |
| author_facet | Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Alshammari, Farhan Alheibshy, Fawaz Sammour, Rana M.F. Doolaanea, Abd Almonem |
| author_sort | Almurisi, Samah Hamed |
| collection | UMP |
| description | The stability of the medicinal product is a major concern in the pharmaceutical industry and health authorities, whose goal is to guarantee that drugs are delivered to patients without loss of therapeutic properties. This study aims to evaluate the effect of environmental conditions and packaging on the stability of paracetamol instant jelly sachets based on both chemical and physical stability. The paracetamol instant jelly was packaged in plastic sachets (packaging 1) and sealed aluminium bags in screw-capped amber glass bottles (packaging 2), which were stored in real-time and accelerated stability chambers for 3 months. Samples were taken out from the chambers and were characterised for appearance, moisture content, texture, viscosity, in vitro drug release, paracetamol content, and 4-aminophenol level at different time points. The real-time storage condition at a lower temperature maintained the stability of the paracetamol instant jelly, while the accelerated condition led to a significant change in the formulation properties. In addition, the proper packaging of paracetamol instant jelly maintained the paracetamol’s stability, regardless of environmental conditions, for three months. The results show that the environmental conditions and packaging play a significant role in maintaining paracetamol instant jelly stability. |
| first_indexed | 2024-03-06T12:55:46Z |
| format | Article |
| id | UMPir33579 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:55:46Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | UMPir335792022-04-15T03:28:57Z http://umpir.ump.edu.my/id/eprint/33579/ Stability of paracetamol instant jelly for reconstitution: Impact of packaging, temperature and humidity Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Alshammari, Farhan Alheibshy, Fawaz Sammour, Rana M.F. Doolaanea, Abd Almonem QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology The stability of the medicinal product is a major concern in the pharmaceutical industry and health authorities, whose goal is to guarantee that drugs are delivered to patients without loss of therapeutic properties. This study aims to evaluate the effect of environmental conditions and packaging on the stability of paracetamol instant jelly sachets based on both chemical and physical stability. The paracetamol instant jelly was packaged in plastic sachets (packaging 1) and sealed aluminium bags in screw-capped amber glass bottles (packaging 2), which were stored in real-time and accelerated stability chambers for 3 months. Samples were taken out from the chambers and were characterised for appearance, moisture content, texture, viscosity, in vitro drug release, paracetamol content, and 4-aminophenol level at different time points. The real-time storage condition at a lower temperature maintained the stability of the paracetamol instant jelly, while the accelerated condition led to a significant change in the formulation properties. In addition, the proper packaging of paracetamol instant jelly maintained the paracetamol’s stability, regardless of environmental conditions, for three months. The results show that the environmental conditions and packaging play a significant role in maintaining paracetamol instant jelly stability. MDPI 2022-02 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/33579/1/Stability%20of%20paracetamol%20instant%20jelly%20for%20reconstitution%20_%20impact.pdf Almurisi, Samah Hamed and AL-japairai, Khater Ahmed Saeed and Alshammari, Farhan and Alheibshy, Fawaz and Sammour, Rana M.F. and Doolaanea, Abd Almonem (2022) Stability of paracetamol instant jelly for reconstitution: Impact of packaging, temperature and humidity. Gels, 8 (3). pp. 1-14. ISSN 2310-2861. (Published) https://doi.org/10.3390/gels8030144 https://doi.org/10.3390/gels8030144 |
| spellingShingle | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Alshammari, Farhan Alheibshy, Fawaz Sammour, Rana M.F. Doolaanea, Abd Almonem Stability of paracetamol instant jelly for reconstitution: Impact of packaging, temperature and humidity |
| title | Stability of paracetamol instant jelly for reconstitution: Impact of packaging, temperature and humidity |
| title_full | Stability of paracetamol instant jelly for reconstitution: Impact of packaging, temperature and humidity |
| title_fullStr | Stability of paracetamol instant jelly for reconstitution: Impact of packaging, temperature and humidity |
| title_full_unstemmed | Stability of paracetamol instant jelly for reconstitution: Impact of packaging, temperature and humidity |
| title_short | Stability of paracetamol instant jelly for reconstitution: Impact of packaging, temperature and humidity |
| title_sort | stability of paracetamol instant jelly for reconstitution impact of packaging temperature and humidity |
| topic | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/33579/1/Stability%20of%20paracetamol%20instant%20jelly%20for%20reconstitution%20_%20impact.pdf |
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