Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response
The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2017
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/33616/1/Nanohydroxyapatite%20coated%20hydroxyethyl%20cellulose%20poly.pdf |
| _version_ | 1825814241574125568 |
|---|---|
| author | Sugandha, Chahal Fathima Shahitha, Jahir Hussain Mashitah, Mohd Yusoff Mohammad Syaiful Bahari, Abdull Rasad Anuj, Kumar |
| author_facet | Sugandha, Chahal Fathima Shahitha, Jahir Hussain Mashitah, Mohd Yusoff Mohammad Syaiful Bahari, Abdull Rasad Anuj, Kumar |
| author_sort | Sugandha, Chahal |
| collection | UMP |
| description | The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the nHA was formed uniformly over the nanofibers. The nHA mineralization enhanced the tensile strength and reduced the elongation at breakage of scaffolds. The wettability of the nanofibrous scaffolds was significantly improved. The in vitro biocompatibility of scaffolds was evaluated with human osteosarcoma cells. nHA-coated scaffolds had a favorable effect on the proliferation and differentiation of osteosarcoma cell and could be a potential candidate for bone regeneration. |
| first_indexed | 2024-03-06T12:55:52Z |
| format | Article |
| id | UMPir33616 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:55:52Z |
| publishDate | 2017 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | UMPir336162022-08-25T08:07:04Z http://umpir.ump.edu.my/id/eprint/33616/ Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response Sugandha, Chahal Fathima Shahitha, Jahir Hussain Mashitah, Mohd Yusoff Mohammad Syaiful Bahari, Abdull Rasad Anuj, Kumar TA Engineering (General). Civil engineering (General) The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the nHA was formed uniformly over the nanofibers. The nHA mineralization enhanced the tensile strength and reduced the elongation at breakage of scaffolds. The wettability of the nanofibrous scaffolds was significantly improved. The in vitro biocompatibility of scaffolds was evaluated with human osteosarcoma cells. nHA-coated scaffolds had a favorable effect on the proliferation and differentiation of osteosarcoma cell and could be a potential candidate for bone regeneration. Taylor & Francis 2017 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/33616/1/Nanohydroxyapatite%20coated%20hydroxyethyl%20cellulose%20poly.pdf Sugandha, Chahal and Fathima Shahitha, Jahir Hussain and Mashitah, Mohd Yusoff and Mohammad Syaiful Bahari, Abdull Rasad and Anuj, Kumar (2017) Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response. International Journal of Polymeric Materials and Polymeric Biomaterials, 66 (3). 115 -122. ISSN 0091-4037(Print); 1563-535X(Online). (Published) https://doi.org/10.1080/00914037.2016.1190926 https://doi.org/10.1080/00914037.2016.1190926 |
| spellingShingle | TA Engineering (General). Civil engineering (General) Sugandha, Chahal Fathima Shahitha, Jahir Hussain Mashitah, Mohd Yusoff Mohammad Syaiful Bahari, Abdull Rasad Anuj, Kumar Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_full | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_fullStr | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_full_unstemmed | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_short | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_sort | nanohydroxyapatite coated hydroxyethyl cellulose poly vinyl alcohol electrospun scaffolds and their cellular response |
| topic | TA Engineering (General). Civil engineering (General) |
| url | http://umpir.ump.edu.my/id/eprint/33616/1/Nanohydroxyapatite%20coated%20hydroxyethyl%20cellulose%20poly.pdf |
| work_keys_str_mv | AT sugandhachahal nanohydroxyapatitecoatedhydroxyethylcellulosepolyvinylalcoholelectrospunscaffoldsandtheircellularresponse AT fathimashahithajahirhussain nanohydroxyapatitecoatedhydroxyethylcellulosepolyvinylalcoholelectrospunscaffoldsandtheircellularresponse AT mashitahmohdyusoff nanohydroxyapatitecoatedhydroxyethylcellulosepolyvinylalcoholelectrospunscaffoldsandtheircellularresponse AT mohammadsyaifulbahariabdullrasad nanohydroxyapatitecoatedhydroxyethylcellulosepolyvinylalcoholelectrospunscaffoldsandtheircellularresponse AT anujkumar nanohydroxyapatitecoatedhydroxyethylcellulosepolyvinylalcoholelectrospunscaffoldsandtheircellularresponse |