Multiscale Modelling of Brain Tissue Oxygen and Glucose Dynamics in Tortuous Capillary during Ischaemia-Reperfusion
Brain ischaemia causes reduction of cerebral blood flow, which interrupts the transport of oxygen and glucose to brain tissue. These transport efficiencies have also been associated with the complex cerebral microvasculature. In this study, the importance of cerebral capillary complexity and tissue...
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| Format: | Article |
| Language: | English |
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Elsevier
2022
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| Online Access: | http://umpir.ump.edu.my/id/eprint/33806/1/Multiscale%20Modelling%20of%20Brain%20Tissue.pdf |
| _version_ | 1825814278495535104 |
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| author | Mohd Jamil M., Mokhtarudin Wan Naimah, W. A. Naim Abbas, Shabudin Payne, Stephen J. |
| author_facet | Mohd Jamil M., Mokhtarudin Wan Naimah, W. A. Naim Abbas, Shabudin Payne, Stephen J. |
| author_sort | Mohd Jamil M., Mokhtarudin |
| collection | UMP |
| description | Brain ischaemia causes reduction of cerebral blood flow, which interrupts the transport of oxygen and glucose to brain tissue. These transport efficiencies have also been associated with the complex cerebral microvasculature. In this study, the importance of cerebral capillary complexity and tissue interstitial porosity in oxygen and glucose transport and metabolism during brain tissue ischaemia is investigated using asymptotic expansion homogenization method. Applying this technique produces new macroscale governing equations with associated microscale cell problems. Solving the latter on brain tissue microstructural geometry will obtain parametric tensors namely the conductivities in capillary, K and interstitial space, E; and the diffusivities of substrate in capillary, DM,c, and in interstitial space, DM,t. From the microscale simulations, increasing the capillary tortuosity resulted in decrement of K and DM,c, but no significant changes on E and DM,t. Meanwhile, increasing the capillary radius resulted in the decrease of all parameters except K. Then, the parametric tensors obtained are used to solve the macroscale governing equations on a one-dimensional brain model under ischaemia-reperfusion conditions. From the macroscale simulations, changing the capillary tortuosity affects the uptake and metabolism of oxygen and glucose during brain ischaemia-reperfusion. In addition, in more tortuous capillaries, oxygen and glucose are utilized rapidly at tissues proximal to the capillary during the reperfusion process, leaving only a small amount of these substrates for distal tissues. This could be associated with severe stroke outcome. It is proposed that the capillary tortuosity of a patient could potentially be used as an additional indicator in determining the severity of ischaemic stroke. |
| first_indexed | 2024-03-06T12:56:24Z |
| format | Article |
| id | UMPir33806 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:56:24Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | UMPir338062022-04-20T07:53:35Z http://umpir.ump.edu.my/id/eprint/33806/ Multiscale Modelling of Brain Tissue Oxygen and Glucose Dynamics in Tortuous Capillary during Ischaemia-Reperfusion Mohd Jamil M., Mokhtarudin Wan Naimah, W. A. Naim Abbas, Shabudin Payne, Stephen J. RC Internal medicine TJ Mechanical engineering and machinery Brain ischaemia causes reduction of cerebral blood flow, which interrupts the transport of oxygen and glucose to brain tissue. These transport efficiencies have also been associated with the complex cerebral microvasculature. In this study, the importance of cerebral capillary complexity and tissue interstitial porosity in oxygen and glucose transport and metabolism during brain tissue ischaemia is investigated using asymptotic expansion homogenization method. Applying this technique produces new macroscale governing equations with associated microscale cell problems. Solving the latter on brain tissue microstructural geometry will obtain parametric tensors namely the conductivities in capillary, K and interstitial space, E; and the diffusivities of substrate in capillary, DM,c, and in interstitial space, DM,t. From the microscale simulations, increasing the capillary tortuosity resulted in decrement of K and DM,c, but no significant changes on E and DM,t. Meanwhile, increasing the capillary radius resulted in the decrease of all parameters except K. Then, the parametric tensors obtained are used to solve the macroscale governing equations on a one-dimensional brain model under ischaemia-reperfusion conditions. From the macroscale simulations, changing the capillary tortuosity affects the uptake and metabolism of oxygen and glucose during brain ischaemia-reperfusion. In addition, in more tortuous capillaries, oxygen and glucose are utilized rapidly at tissues proximal to the capillary during the reperfusion process, leaving only a small amount of these substrates for distal tissues. This could be associated with severe stroke outcome. It is proposed that the capillary tortuosity of a patient could potentially be used as an additional indicator in determining the severity of ischaemic stroke. Elsevier 2022 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/33806/1/Multiscale%20Modelling%20of%20Brain%20Tissue.pdf Mohd Jamil M., Mokhtarudin and Wan Naimah, W. A. Naim and Abbas, Shabudin and Payne, Stephen J. (2022) Multiscale Modelling of Brain Tissue Oxygen and Glucose Dynamics in Tortuous Capillary during Ischaemia-Reperfusion. Applied Mathematical Modelling. ISSN 0307-904X. (In Press / Online First) (In Press / Online First) https://doi.org/10.1016/j.apm.2022.04.001 https://doi.org/10.1016/j.apm.2022.04.001 |
| spellingShingle | RC Internal medicine TJ Mechanical engineering and machinery Mohd Jamil M., Mokhtarudin Wan Naimah, W. A. Naim Abbas, Shabudin Payne, Stephen J. Multiscale Modelling of Brain Tissue Oxygen and Glucose Dynamics in Tortuous Capillary during Ischaemia-Reperfusion |
| title | Multiscale Modelling of Brain Tissue Oxygen and Glucose Dynamics in Tortuous Capillary during Ischaemia-Reperfusion |
| title_full | Multiscale Modelling of Brain Tissue Oxygen and Glucose Dynamics in Tortuous Capillary during Ischaemia-Reperfusion |
| title_fullStr | Multiscale Modelling of Brain Tissue Oxygen and Glucose Dynamics in Tortuous Capillary during Ischaemia-Reperfusion |
| title_full_unstemmed | Multiscale Modelling of Brain Tissue Oxygen and Glucose Dynamics in Tortuous Capillary during Ischaemia-Reperfusion |
| title_short | Multiscale Modelling of Brain Tissue Oxygen and Glucose Dynamics in Tortuous Capillary during Ischaemia-Reperfusion |
| title_sort | multiscale modelling of brain tissue oxygen and glucose dynamics in tortuous capillary during ischaemia reperfusion |
| topic | RC Internal medicine TJ Mechanical engineering and machinery |
| url | http://umpir.ump.edu.my/id/eprint/33806/1/Multiscale%20Modelling%20of%20Brain%20Tissue.pdf |
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