A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer
Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing Co Pte Ltd
2022
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/34459/1/A%20Mini-Review%20on%20the%20Insight%20into%20the%20Effect%20of%20Natural.pdf |
| _version_ | 1796995154594234368 |
|---|---|
| author | Kelvin Wong, Khai Voon Ahmad Mahfuz, Gazali Normaiza, Zamri Kamal, Rullah Mohd Fadhlizil Fasihi, Mohd Aluwi |
| author_facet | Kelvin Wong, Khai Voon Ahmad Mahfuz, Gazali Normaiza, Zamri Kamal, Rullah Mohd Fadhlizil Fasihi, Mohd Aluwi |
| author_sort | Kelvin Wong, Khai Voon |
| collection | UMP |
| description | Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of different cancer, making it a critical target for cancer treatment. Inhibition of the mTOR protein kinase can cause autophagic cell death. It is known that covalent inhibitors have become a prominent issue in drug discovery, with covalent inhibitors focusing on α,β-unsaturated carbonyl molecules. Structural modifications to α,β-unsaturated carbonyl may be one of the finest avenues for developing the best breast cancer medication. This review article discusses recent research on natural and synthetic α,β-unsaturated carbonyls and their anti-cancer properties targeting on mTOR, with SAR to showcase the efficacy of synthetic natural products compared to parental compounds using both biological assays and in silico studies. |
| first_indexed | 2024-03-06T12:58:08Z |
| format | Article |
| id | UMPir34459 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:58:08Z |
| publishDate | 2022 |
| publisher | World Scientific Publishing Co Pte Ltd |
| record_format | dspace |
| spelling | UMPir344592022-06-17T08:36:28Z http://umpir.ump.edu.my/id/eprint/34459/ A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer Kelvin Wong, Khai Voon Ahmad Mahfuz, Gazali Normaiza, Zamri Kamal, Rullah Mohd Fadhlizil Fasihi, Mohd Aluwi R Medicine (General) TP Chemical technology Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of different cancer, making it a critical target for cancer treatment. Inhibition of the mTOR protein kinase can cause autophagic cell death. It is known that covalent inhibitors have become a prominent issue in drug discovery, with covalent inhibitors focusing on α,β-unsaturated carbonyl molecules. Structural modifications to α,β-unsaturated carbonyl may be one of the finest avenues for developing the best breast cancer medication. This review article discusses recent research on natural and synthetic α,β-unsaturated carbonyls and their anti-cancer properties targeting on mTOR, with SAR to showcase the efficacy of synthetic natural products compared to parental compounds using both biological assays and in silico studies. World Scientific Publishing Co Pte Ltd 2022 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/34459/1/A%20Mini-Review%20on%20the%20Insight%20into%20the%20Effect%20of%20Natural.pdf Kelvin Wong, Khai Voon and Ahmad Mahfuz, Gazali and Normaiza, Zamri and Kamal, Rullah and Mohd Fadhlizil Fasihi, Mohd Aluwi (2022) A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer. Journal of Computational Biophysics and Chemistry. pp. 1-16. ISSN 2737-4173. (Published) https://doi.org/10.1142/S2737416522300024 https://doi.org/10.1142/S2737416522300024 |
| spellingShingle | R Medicine (General) TP Chemical technology Kelvin Wong, Khai Voon Ahmad Mahfuz, Gazali Normaiza, Zamri Kamal, Rullah Mohd Fadhlizil Fasihi, Mohd Aluwi A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer |
| title | A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer |
| title_full | A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer |
| title_fullStr | A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer |
| title_full_unstemmed | A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer |
| title_short | A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer |
| title_sort | mini review on the insight into the effect of natural and synthetic α β unsaturated carbonyl containing compounds on pi3k akt mtor signaling pathways to treat breast cancer |
| topic | R Medicine (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/34459/1/A%20Mini-Review%20on%20the%20Insight%20into%20the%20Effect%20of%20Natural.pdf |
| work_keys_str_mv | AT kelvinwongkhaivoon aminireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer AT ahmadmahfuzgazali aminireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer AT normaizazamri aminireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer AT kamalrullah aminireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer AT mohdfadhlizilfasihimohdaluwi aminireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer AT kelvinwongkhaivoon minireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer AT ahmadmahfuzgazali minireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer AT normaizazamri minireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer AT kamalrullah minireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer AT mohdfadhlizilfasihimohdaluwi minireviewontheinsightintotheeffectofnaturalandsyntheticabunsaturatedcarbonylcontainingcompoundsonpi3kaktmtorsignalingpathwaystotreatbreastcancer |