Evaluation of mechanical and thermal properties of Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule
The inherent source of gelatin used for commercial hard capsules causes a surging demand on vegetarian capsules. In this work, carrageenan is utilized in preparing hard capsules to meet consumer preferences. Hydroxypropyl methylcellulose (HPMC) was incorporated as a reinforcing agent to improve the...
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| Format: | Article |
| Language: | English |
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John Wiley & Sons
2022
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| Online Access: | http://umpir.ump.edu.my/id/eprint/34737/1/Full%20Manuscrip_CJCE-21-0682.R1_Proof.pdf |
| _version_ | 1825824091510145024 |
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| author | Nur Amalina, Ramli Fatmawati, Adam Khairatun Najwa, Mohd Amin Adibi, M. Nor Ries, Michael E. |
| author_facet | Nur Amalina, Ramli Fatmawati, Adam Khairatun Najwa, Mohd Amin Adibi, M. Nor Ries, Michael E. |
| author_sort | Nur Amalina, Ramli |
| collection | UMP |
| description | The inherent source of gelatin used for commercial hard capsules causes a surging demand on vegetarian capsules. In this work, carrageenan is utilized in preparing hard capsules to meet consumer preferences. Hydroxypropyl methylcellulose (HPMC) was incorporated as a reinforcing agent to improve the low mechanical properties of hard capsules made of carrageenan. HPMC concentration was manipulated from 0.2 w/v% to 1.0 w/v% in the carrageenan matrix. Increasing concentration of HPMC exerts significant effects on the tensile strength and elongation at break, with an improvement of 59.1% and 46.9%, respectively, at the optimized HPMC concentration of 0.8 w/v%. The loop strength of the capsule is also increased by 56.4% with decreasing moisture content. A downfield movement around 3.20 ppm of the carrageenan proton to 3.33 ppm in 1H-NMR spectrum suggests the formation of intermolecular hydrogen bonding between carrageenan and HPMC, which correlates to the results of FTIR and zeta potential. The glass transition of the film is increased from 37.8°C to 65.3°C, showing an upgrade in thermal stability. The film possesses a major mass loss with an activation energy of 64.7 kJ/mol with an increment of 43.4% compared to the control carrageenan. These findings support the conclusion that HPMC enhanced the mechanical properties and thermal stability of the carrageenan film, and the comprehensive analysis of the molecular interaction and decomposition kinetics subsequently may expand the application fields of the carrageenanHPMC hard capsule as an alternative to gelatin in the future. |
| first_indexed | 2024-03-06T12:58:55Z |
| format | Article |
| id | UMPir34737 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:58:55Z |
| publishDate | 2022 |
| publisher | John Wiley & Sons |
| record_format | dspace |
| spelling | UMPir347372022-08-23T01:16:20Z http://umpir.ump.edu.my/id/eprint/34737/ Evaluation of mechanical and thermal properties of Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule Nur Amalina, Ramli Fatmawati, Adam Khairatun Najwa, Mohd Amin Adibi, M. Nor Ries, Michael E. TP Chemical technology The inherent source of gelatin used for commercial hard capsules causes a surging demand on vegetarian capsules. In this work, carrageenan is utilized in preparing hard capsules to meet consumer preferences. Hydroxypropyl methylcellulose (HPMC) was incorporated as a reinforcing agent to improve the low mechanical properties of hard capsules made of carrageenan. HPMC concentration was manipulated from 0.2 w/v% to 1.0 w/v% in the carrageenan matrix. Increasing concentration of HPMC exerts significant effects on the tensile strength and elongation at break, with an improvement of 59.1% and 46.9%, respectively, at the optimized HPMC concentration of 0.8 w/v%. The loop strength of the capsule is also increased by 56.4% with decreasing moisture content. A downfield movement around 3.20 ppm of the carrageenan proton to 3.33 ppm in 1H-NMR spectrum suggests the formation of intermolecular hydrogen bonding between carrageenan and HPMC, which correlates to the results of FTIR and zeta potential. The glass transition of the film is increased from 37.8°C to 65.3°C, showing an upgrade in thermal stability. The film possesses a major mass loss with an activation energy of 64.7 kJ/mol with an increment of 43.4% compared to the control carrageenan. These findings support the conclusion that HPMC enhanced the mechanical properties and thermal stability of the carrageenan film, and the comprehensive analysis of the molecular interaction and decomposition kinetics subsequently may expand the application fields of the carrageenanHPMC hard capsule as an alternative to gelatin in the future. John Wiley & Sons 2022 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/34737/1/Full%20Manuscrip_CJCE-21-0682.R1_Proof.pdf Nur Amalina, Ramli and Fatmawati, Adam and Khairatun Najwa, Mohd Amin and Adibi, M. Nor and Ries, Michael E. (2022) Evaluation of mechanical and thermal properties of Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule. The Canadian Journal of Chemical Engineering. pp. 1-13. ISSN 1939-019X. (Published) http://doi.org/10.1002/cjce.24595. https://doi.org/10.1080/02726351.2022.2063210 |
| spellingShingle | TP Chemical technology Nur Amalina, Ramli Fatmawati, Adam Khairatun Najwa, Mohd Amin Adibi, M. Nor Ries, Michael E. Evaluation of mechanical and thermal properties of Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule |
| title | Evaluation of mechanical and thermal properties of
Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule |
| title_full | Evaluation of mechanical and thermal properties of
Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule |
| title_fullStr | Evaluation of mechanical and thermal properties of
Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule |
| title_full_unstemmed | Evaluation of mechanical and thermal properties of
Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule |
| title_short | Evaluation of mechanical and thermal properties of
Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule |
| title_sort | evaluation of mechanical and thermal properties of carrageenan hydroxypropyl methyl cellulose hard capsule |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/34737/1/Full%20Manuscrip_CJCE-21-0682.R1_Proof.pdf |
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