Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort
Determining the major human exposure pathways is a prerequisite for the development of effective management strategies for environmental pollutants such as chlorinated paraffins (CPs). As a first step, the internal and external exposure to CPs were quantified for a well-defined human cohort. CPs in...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2022
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/35912/1/yuan2022_v1.pdf |
| _version_ | 1825814682624065536 |
|---|---|
| author | Yuan, Bo Haug, Line Småstuen Tay, Joo Hui Padilla-Sanchez, Juan Antonio Papadopoulou, Eleni de Wit, Cynthia A. |
| author_facet | Yuan, Bo Haug, Line Småstuen Tay, Joo Hui Padilla-Sanchez, Juan Antonio Papadopoulou, Eleni de Wit, Cynthia A. |
| author_sort | Yuan, Bo |
| collection | UMP |
| description | Determining the major human exposure pathways is a prerequisite for the development of effective management strategies for environmental pollutants such as chlorinated paraffins (CPs). As a first step, the internal and external exposure to CPs were quantified for a well-defined human cohort. CPs in participants' plasma and diet samples were analyzed in the present study, and previous results on paired air, dust, and hand wipe samples were used for the total exposure assessment. Both one compartment pharmacokinetic modeling and forensic fingerprinting indicate that dietary intake contributed the most to body burden of CPs in this cohort, contributing a median of 60-88% of the total daily intakes. The contribution from dust ingestion and dermal exposure was greater for the intake of long-chain CPs (LCCPs) than short-chain CPs (SCCPs), while the contribution from inhalation was greater for the intake of SCCPs than medium-chain CPs (MCCPs) and LCCPs. Significantly higher concentrations of SCCPs and MCCPs were observed in diets containing butter and eggs, respectively (p < 0.05). Additionally, other exposure sources were correlated to plasma levels of CPs, including residence construction parameters such as the construction year (p < 0.05). This human exposure to CPs is not a local case. From a global perspective, there are major knowledge gaps in biomonitoring and exposure data for CPs from regions other than China and European countries. |
| first_indexed | 2024-03-06T13:02:11Z |
| format | Article |
| id | UMPir35912 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T13:02:11Z |
| publishDate | 2022 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | UMPir359122022-12-28T08:02:58Z http://umpir.ump.edu.my/id/eprint/35912/ Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort Yuan, Bo Haug, Line Småstuen Tay, Joo Hui Padilla-Sanchez, Juan Antonio Papadopoulou, Eleni de Wit, Cynthia A. Q Science (General) QD Chemistry Determining the major human exposure pathways is a prerequisite for the development of effective management strategies for environmental pollutants such as chlorinated paraffins (CPs). As a first step, the internal and external exposure to CPs were quantified for a well-defined human cohort. CPs in participants' plasma and diet samples were analyzed in the present study, and previous results on paired air, dust, and hand wipe samples were used for the total exposure assessment. Both one compartment pharmacokinetic modeling and forensic fingerprinting indicate that dietary intake contributed the most to body burden of CPs in this cohort, contributing a median of 60-88% of the total daily intakes. The contribution from dust ingestion and dermal exposure was greater for the intake of long-chain CPs (LCCPs) than short-chain CPs (SCCPs), while the contribution from inhalation was greater for the intake of SCCPs than medium-chain CPs (MCCPs) and LCCPs. Significantly higher concentrations of SCCPs and MCCPs were observed in diets containing butter and eggs, respectively (p < 0.05). Additionally, other exposure sources were correlated to plasma levels of CPs, including residence construction parameters such as the construction year (p < 0.05). This human exposure to CPs is not a local case. From a global perspective, there are major knowledge gaps in biomonitoring and exposure data for CPs from regions other than China and European countries. American Chemical Society 2022-11-15 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/35912/1/yuan2022_v1.pdf Yuan, Bo and Haug, Line Småstuen and Tay, Joo Hui and Padilla-Sanchez, Juan Antonio and Papadopoulou, Eleni and de Wit, Cynthia A. (2022) Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort. Environmental Science & Technology, 56. pp. 17080-17089. ISSN 1520-5851. (Published) http://10.1021/acs.est.2c04998 https://doi.org/10.1021/acs.est.2c04998 |
| spellingShingle | Q Science (General) QD Chemistry Yuan, Bo Haug, Line Småstuen Tay, Joo Hui Padilla-Sanchez, Juan Antonio Papadopoulou, Eleni de Wit, Cynthia A. Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort |
| title | Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort |
| title_full | Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort |
| title_fullStr | Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort |
| title_full_unstemmed | Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort |
| title_short | Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort |
| title_sort | dietary intake contributed the most to chlorinated paraffin body burden in a norwegian cohort |
| topic | Q Science (General) QD Chemistry |
| url | http://umpir.ump.edu.my/id/eprint/35912/1/yuan2022_v1.pdf |
| work_keys_str_mv | AT yuanbo dietaryintakecontributedthemosttochlorinatedparaffinbodyburdeninanorwegiancohort AT hauglinesmastuen dietaryintakecontributedthemosttochlorinatedparaffinbodyburdeninanorwegiancohort AT tayjoohui dietaryintakecontributedthemosttochlorinatedparaffinbodyburdeninanorwegiancohort AT padillasanchezjuanantonio dietaryintakecontributedthemosttochlorinatedparaffinbodyburdeninanorwegiancohort AT papadopouloueleni dietaryintakecontributedthemosttochlorinatedparaffinbodyburdeninanorwegiancohort AT dewitcynthiaa dietaryintakecontributedthemosttochlorinatedparaffinbodyburdeninanorwegiancohort |