Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study
Background: Hospital-based stroke rehabilitation for stroke survivors in developing countries may be limited by staffing ratios and length of stay that could hamper recovery potential. Thus, a home-based, gamified rehabilitation system (i.e., IntelliRehab) was tested for its ability to increase cere...
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| Format: | Article |
| Language: | English |
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BioMed Central Ltd
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| Online Access: | http://umpir.ump.edu.my/id/eprint/37399/1/Regional%20cerebral%20blood%20perfusion%20changes%20in%20chronic%20stroke%20survivors%20as%20potential%20brain%20correlates%20of%20the%20functional%20outcome.pdf |
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| author | Firwana, Younis M.S. Mohd Khairul Izamil, Zolkefley Hasnetty Zuria, Mohamed Hatta Rowbin, Christina Che Nasril, Che Mohd Nassir Muhammad Hafiz, Hanafi Mohd Shafie, Abdullah Keserci, Bilgin M. Lannin, Natasha A. Muzaimi, Mustapha |
| author_facet | Firwana, Younis M.S. Mohd Khairul Izamil, Zolkefley Hasnetty Zuria, Mohamed Hatta Rowbin, Christina Che Nasril, Che Mohd Nassir Muhammad Hafiz, Hanafi Mohd Shafie, Abdullah Keserci, Bilgin M. Lannin, Natasha A. Muzaimi, Mustapha |
| author_sort | Firwana, Younis M.S. |
| collection | UMP |
| description | Background: Hospital-based stroke rehabilitation for stroke survivors in developing countries may be limited by staffing ratios and length of stay that could hamper recovery potential. Thus, a home-based, gamified rehabilitation system (i.e., IntelliRehab) was tested for its ability to increase cerebral blood flow (CBF), and the secondary impact of changes on the upper limb motor function and functional outcomes. Objective: To explore the effect of IntelliRehab on CBF in chronic stroke patients and its correlation with the upper limb motor function. Methods: Two-dimensional pulsed Arterial Spin Labelling (2D-pASL) was used to obtain CBF images of stable, chronic stroke subjects (n = 8) over 3-months intervention period. CBF alterations were mapped, and the detected differences were marked as regions of interest. Motor functions represented by Fugl-Meyer Upper Extremity Assessment (FMA) and Stroke Impact Scale (SIS) were used to assess the primary and secondary outcomes, respectively. Results: Regional CBF were significantly increased in right inferior temporal gyrus and left superior temporal white matter after 1-month (p = 0.044) and 3-months (p = 0.01) of rehabilitation, respectively. However, regional CBF in left middle fronto-orbital gyrus significantly declined after 1-month of rehabilitation (p = 0.012). Moreover, SIS-Q7 and FMA scores significantly increased after 1-month and 3-months of rehabilitation. There were no significant correlations, however, between CBF changes and upper limb motor function. Conclusions: Participants demonstrated improved motor functions, supporting the benefit of using IntelliRehab as a tool for home-based rehabilitation. However, within-participant improvements may have limited potential that suggests the need for a timely administration of IntelliRehab to get the maximum capacity of improvement. |
| first_indexed | 2024-03-06T13:05:47Z |
| format | Article |
| id | UMPir37399 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T13:05:47Z |
| publisher | BioMed Central Ltd |
| record_format | dspace |
| spelling | UMPir373992023-08-16T04:46:27Z http://umpir.ump.edu.my/id/eprint/37399/ Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study Firwana, Younis M.S. Mohd Khairul Izamil, Zolkefley Hasnetty Zuria, Mohamed Hatta Rowbin, Christina Che Nasril, Che Mohd Nassir Muhammad Hafiz, Hanafi Mohd Shafie, Abdullah Keserci, Bilgin M. Lannin, Natasha A. Muzaimi, Mustapha HD28 Management. Industrial Management Q Science (General) T Technology (General) Background: Hospital-based stroke rehabilitation for stroke survivors in developing countries may be limited by staffing ratios and length of stay that could hamper recovery potential. Thus, a home-based, gamified rehabilitation system (i.e., IntelliRehab) was tested for its ability to increase cerebral blood flow (CBF), and the secondary impact of changes on the upper limb motor function and functional outcomes. Objective: To explore the effect of IntelliRehab on CBF in chronic stroke patients and its correlation with the upper limb motor function. Methods: Two-dimensional pulsed Arterial Spin Labelling (2D-pASL) was used to obtain CBF images of stable, chronic stroke subjects (n = 8) over 3-months intervention period. CBF alterations were mapped, and the detected differences were marked as regions of interest. Motor functions represented by Fugl-Meyer Upper Extremity Assessment (FMA) and Stroke Impact Scale (SIS) were used to assess the primary and secondary outcomes, respectively. Results: Regional CBF were significantly increased in right inferior temporal gyrus and left superior temporal white matter after 1-month (p = 0.044) and 3-months (p = 0.01) of rehabilitation, respectively. However, regional CBF in left middle fronto-orbital gyrus significantly declined after 1-month of rehabilitation (p = 0.012). Moreover, SIS-Q7 and FMA scores significantly increased after 1-month and 3-months of rehabilitation. There were no significant correlations, however, between CBF changes and upper limb motor function. Conclusions: Participants demonstrated improved motor functions, supporting the benefit of using IntelliRehab as a tool for home-based rehabilitation. However, within-participant improvements may have limited potential that suggests the need for a timely administration of IntelliRehab to get the maximum capacity of improvement. BioMed Central Ltd Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/37399/1/Regional%20cerebral%20blood%20perfusion%20changes%20in%20chronic%20stroke%20survivors%20as%20potential%20brain%20correlates%20of%20the%20functional%20outcome.pdf Firwana, Younis M.S. and Mohd Khairul Izamil, Zolkefley and Hasnetty Zuria, Mohamed Hatta and Rowbin, Christina and Che Nasril, Che Mohd Nassir and Muhammad Hafiz, Hanafi and Mohd Shafie, Abdullah and Keserci, Bilgin M. and Lannin, Natasha A. and Muzaimi, Mustapha Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study. Journal of NeuroEngineering and Rehabilitation, 19 (94). pp. 1-14. ISSN 1743-0003. (Published) https://doi.org/10.1186/s12984-022-01072-w https://doi.org/10.1186/s12984-022-01072-w |
| spellingShingle | HD28 Management. Industrial Management Q Science (General) T Technology (General) Firwana, Younis M.S. Mohd Khairul Izamil, Zolkefley Hasnetty Zuria, Mohamed Hatta Rowbin, Christina Che Nasril, Che Mohd Nassir Muhammad Hafiz, Hanafi Mohd Shafie, Abdullah Keserci, Bilgin M. Lannin, Natasha A. Muzaimi, Mustapha Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study |
| title | Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study |
| title_full | Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study |
| title_fullStr | Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study |
| title_full_unstemmed | Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study |
| title_short | Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study |
| title_sort | regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home based rehabilitation intellirehab a pilot study |
| topic | HD28 Management. Industrial Management Q Science (General) T Technology (General) |
| url | http://umpir.ump.edu.my/id/eprint/37399/1/Regional%20cerebral%20blood%20perfusion%20changes%20in%20chronic%20stroke%20survivors%20as%20potential%20brain%20correlates%20of%20the%20functional%20outcome.pdf |
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