Curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine: An in-vitro assessment
This article demonstrates the development of nanofibrous cloths by electrospinning of renewable materials, i.e., curcumin-loaded 90% cellulose acetate (CA)/10% poly(ε-caprolactone) (PCL), for applications in regenerative medicine. The CA is derived from the biomass waste of the oil palm plantation (...
| Hlavní autoři: | , , , , , , , |
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| Médium: | Článek |
| Jazyk: | English English |
| Vydáno: |
Elsevier Ltd
2022
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| Témata: | |
| On-line přístup: | http://umpir.ump.edu.my/id/eprint/38059/1/Int%20J%20Biol%20Macro_Nadirah.pdf http://umpir.ump.edu.my/id/eprint/38059/7/Curcumin%20loaded%20waste%20biomass%20resourced%20cellulosic%20nanofiber%20cloth%20.pdf |
| _version_ | 1825815043845914624 |
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| author | Nurul Nadirah, Suteris Amina, Yasin Izan Izwan, Misnon Rasidi, Roslan Farah Hanani, Zulkifli Mohd Hasbi, Ab. Rahim Venugopal, Jayarama Reddy Rajan, Jose |
| author_facet | Nurul Nadirah, Suteris Amina, Yasin Izan Izwan, Misnon Rasidi, Roslan Farah Hanani, Zulkifli Mohd Hasbi, Ab. Rahim Venugopal, Jayarama Reddy Rajan, Jose |
| author_sort | Nurul Nadirah, Suteris |
| collection | UMP |
| description | This article demonstrates the development of nanofibrous cloths by electrospinning of renewable materials, i.e., curcumin-loaded 90% cellulose acetate (CA)/10% poly(ε-caprolactone) (PCL), for applications in regenerative medicine. The CA is derived from the biomass waste of the oil palm plantation (empty fruit bunch). The nanofiber scaffolds are characterized for the fiber morphology, microstructure, thermal properties, and wettability. The optimized smooth and bead-free electrospun fiber cloth contains 90% CA and 10% PCL in two curcumin compositions (0.5 and 1 wt%). The role of curcumin is shown to be two-fold: the first is its function as a drug and the second is its role in lowering the water contact angle and increasing the hydrophilicity. The hydrophilicity enhancements are related to the hydrogen bonding between the components. The enhanced hydrophilicity contributed to improve the swelling behavior of the scaffolds; the CA/PCL/Cur (0.5%) and the CA/PCL/Cur (1.0%) showed swelling of ~700 and 950%, respectively, in phosphate-buffered saline (PBS). The drug-release studies revealed the highest cumulative drug release of 60% and 78% for CA/PCL/Cur (0.5%) and CA/PCL/Cur (1.0%) nanofibers, respectively. The in-vitro studies showed that CA/PCL/Cur (0.5 wt%) and CA/PCL/Cur (1.0 wt%) nanofiber scaffolds facilitate a higher proliferation and expression of actin in fibroblasts than those scaffolds without curcumin for wound healing applications. |
| first_indexed | 2024-03-06T13:07:34Z |
| format | Article |
| id | UMPir38059 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-03-06T13:07:34Z |
| publishDate | 2022 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | UMPir380592023-08-03T04:48:56Z http://umpir.ump.edu.my/id/eprint/38059/ Curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine: An in-vitro assessment Nurul Nadirah, Suteris Amina, Yasin Izan Izwan, Misnon Rasidi, Roslan Farah Hanani, Zulkifli Mohd Hasbi, Ab. Rahim Venugopal, Jayarama Reddy Rajan, Jose QC Physics QD Chemistry QP Physiology This article demonstrates the development of nanofibrous cloths by electrospinning of renewable materials, i.e., curcumin-loaded 90% cellulose acetate (CA)/10% poly(ε-caprolactone) (PCL), for applications in regenerative medicine. The CA is derived from the biomass waste of the oil palm plantation (empty fruit bunch). The nanofiber scaffolds are characterized for the fiber morphology, microstructure, thermal properties, and wettability. The optimized smooth and bead-free electrospun fiber cloth contains 90% CA and 10% PCL in two curcumin compositions (0.5 and 1 wt%). The role of curcumin is shown to be two-fold: the first is its function as a drug and the second is its role in lowering the water contact angle and increasing the hydrophilicity. The hydrophilicity enhancements are related to the hydrogen bonding between the components. The enhanced hydrophilicity contributed to improve the swelling behavior of the scaffolds; the CA/PCL/Cur (0.5%) and the CA/PCL/Cur (1.0%) showed swelling of ~700 and 950%, respectively, in phosphate-buffered saline (PBS). The drug-release studies revealed the highest cumulative drug release of 60% and 78% for CA/PCL/Cur (0.5%) and CA/PCL/Cur (1.0%) nanofibers, respectively. The in-vitro studies showed that CA/PCL/Cur (0.5 wt%) and CA/PCL/Cur (1.0 wt%) nanofiber scaffolds facilitate a higher proliferation and expression of actin in fibroblasts than those scaffolds without curcumin for wound healing applications. Elsevier Ltd 2022-02 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/38059/1/Int%20J%20Biol%20Macro_Nadirah.pdf pdf en http://umpir.ump.edu.my/id/eprint/38059/7/Curcumin%20loaded%20waste%20biomass%20resourced%20cellulosic%20nanofiber%20cloth%20.pdf Nurul Nadirah, Suteris and Amina, Yasin and Izan Izwan, Misnon and Rasidi, Roslan and Farah Hanani, Zulkifli and Mohd Hasbi, Ab. Rahim and Venugopal, Jayarama Reddy and Rajan, Jose (2022) Curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine: An in-vitro assessment. International Journal of Biological Macromolecules, 189. pp. 147-156. ISSN 0141-8130. (Published) https://doi.org/10.1016/j.ijbiomac.2021.12.006 https://doi.org/10.1016/j.ijbiomac.2021.12.006 |
| spellingShingle | QC Physics QD Chemistry QP Physiology Nurul Nadirah, Suteris Amina, Yasin Izan Izwan, Misnon Rasidi, Roslan Farah Hanani, Zulkifli Mohd Hasbi, Ab. Rahim Venugopal, Jayarama Reddy Rajan, Jose Curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine: An in-vitro assessment |
| title | Curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine: An in-vitro assessment |
| title_full | Curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine: An in-vitro assessment |
| title_fullStr | Curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine: An in-vitro assessment |
| title_full_unstemmed | Curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine: An in-vitro assessment |
| title_short | Curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine: An in-vitro assessment |
| title_sort | curcumin loaded waste biomass resourced cellulosic nanofiber cloth as a potential scaffold for regenerative medicine an in vitro assessment |
| topic | QC Physics QD Chemistry QP Physiology |
| url | http://umpir.ump.edu.my/id/eprint/38059/1/Int%20J%20Biol%20Macro_Nadirah.pdf http://umpir.ump.edu.my/id/eprint/38059/7/Curcumin%20loaded%20waste%20biomass%20resourced%20cellulosic%20nanofiber%20cloth%20.pdf |
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