Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus
A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost. One such cancer is Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy. In 2008, Merkel cell polyomavirus (MCPyV) was discovered as the causative agent of MCC. It is found clonally in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2014
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/38503/1/cancers-06-01267.pdf |
| _version_ | 1825815124044152832 |
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| author | Stakaitytė, Gabrielė Wood, Jennifer J Knight, Laura M. Abdul-Sada, Hussein Adzahar, Noor Suhana Nwogu, Nnenna Macdonald, Andrew Whitehouse, Adrian |
| author_facet | Stakaitytė, Gabrielė Wood, Jennifer J Knight, Laura M. Abdul-Sada, Hussein Adzahar, Noor Suhana Nwogu, Nnenna Macdonald, Andrew Whitehouse, Adrian |
| author_sort | Stakaitytė, Gabrielė |
| collection | UMP |
| description | A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost. One such cancer is Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy. In 2008, Merkel cell polyomavirus (MCPyV) was discovered as the causative agent of MCC. It is found clonally integrated into the majority of MCC tumours, which require MCPyV oncoproteins to survive. Since its discovery, research has begun to reveal the molecular virology of MCPyV, as well as how it induces tumourigenesis. It is thought to be a common skin commensal, found at low levels in healthy individuals. Upon loss of immunosurveillance, MCPyV reactivates, and a heavy viral load is associated with MCC pathogenesis. Although MCPyV is in many ways similar to classical oncogenic polyomaviruses, such as SV40, subtle differences are beginning to emerge. These unique features highlight the singular position MCPyV has as the only human oncogenic polyomavirus, and open up new avenues for therapies against MCC. |
| first_indexed | 2024-03-06T13:08:46Z |
| format | Article |
| id | UMPir38503 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T13:08:46Z |
| publishDate | 2014 |
| publisher | MDPI |
| record_format | dspace |
| spelling | UMPir385032023-08-30T07:21:31Z http://umpir.ump.edu.my/id/eprint/38503/ Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus Stakaitytė, Gabrielė Wood, Jennifer J Knight, Laura M. Abdul-Sada, Hussein Adzahar, Noor Suhana Nwogu, Nnenna Macdonald, Andrew Whitehouse, Adrian QR Microbiology QR355 Virology RM Therapeutics. Pharmacology A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost. One such cancer is Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy. In 2008, Merkel cell polyomavirus (MCPyV) was discovered as the causative agent of MCC. It is found clonally integrated into the majority of MCC tumours, which require MCPyV oncoproteins to survive. Since its discovery, research has begun to reveal the molecular virology of MCPyV, as well as how it induces tumourigenesis. It is thought to be a common skin commensal, found at low levels in healthy individuals. Upon loss of immunosurveillance, MCPyV reactivates, and a heavy viral load is associated with MCC pathogenesis. Although MCPyV is in many ways similar to classical oncogenic polyomaviruses, such as SV40, subtle differences are beginning to emerge. These unique features highlight the singular position MCPyV has as the only human oncogenic polyomavirus, and open up new avenues for therapies against MCC. MDPI 2014-06-27 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/38503/1/cancers-06-01267.pdf Stakaitytė, Gabrielė and Wood, Jennifer J and Knight, Laura M. and Abdul-Sada, Hussein and Adzahar, Noor Suhana and Nwogu, Nnenna and Macdonald, Andrew and Whitehouse, Adrian (2014) Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus. Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour Virus, 6. pp. 1267-1297. ISSN 2072-6694. (Published) http://mdpi.com/10.3390/cancers6031267 |
| spellingShingle | QR Microbiology QR355 Virology RM Therapeutics. Pharmacology Stakaitytė, Gabrielė Wood, Jennifer J Knight, Laura M. Abdul-Sada, Hussein Adzahar, Noor Suhana Nwogu, Nnenna Macdonald, Andrew Whitehouse, Adrian Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus |
| title | Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus |
| title_full | Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus |
| title_fullStr | Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus |
| title_full_unstemmed | Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus |
| title_short | Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus |
| title_sort | merkel cell polyomavirus molecular insights into the most recently discovered human tumour virus |
| topic | QR Microbiology QR355 Virology RM Therapeutics. Pharmacology |
| url | http://umpir.ump.edu.my/id/eprint/38503/1/cancers-06-01267.pdf |
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