Optimization of carboxymethyl cellulose-gum Arab-based hydrogel beads for anticancer drugs delivery
Response surface methodology was successfully utilized to optimize the amounts of carboxymethyl cellulose (CMC) and gum Arab (GA) to fabricate hydrogel beads for the delivery of anticancer drugs. Drug encapsulation efficiency process (%DEE) and cumulative release (%R8h) of hydrogel beads were invest...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier B.V.
2024
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| Online Access: | http://umpir.ump.edu.my/id/eprint/39986/1/Optimization%20of%20carboxymethyl%20cellulose-gum%20Arab-based%20hydrogel%20beads.pdf http://umpir.ump.edu.my/id/eprint/39986/2/Optimization%20of%20carboxymethyl%20cellulose-gum%20Arab-based%20hydrogel%20beads%20for%20anticancer%20drugs%20delivery_ABS.pdf |
| _version_ | 1796996162479194112 |
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| author | Ghawanmeh, Abdullah A. Tan, Ling Ling Ali, Gomaa A.M. Assiri, Mohammed Ali Chong, Kwok Feng |
| author_facet | Ghawanmeh, Abdullah A. Tan, Ling Ling Ali, Gomaa A.M. Assiri, Mohammed Ali Chong, Kwok Feng |
| author_sort | Ghawanmeh, Abdullah A. |
| collection | UMP |
| description | Response surface methodology was successfully utilized to optimize the amounts of carboxymethyl cellulose (CMC) and gum Arab (GA) to fabricate hydrogel beads for the delivery of anticancer drugs. Drug encapsulation efficiency process (%DEE) and cumulative release (%R8h) of hydrogel beads were investigated with different amounts of CMC and GA with Fe (III) cross-linker. The numerical validation resulted in an optimized nanocomposite of CMC (99.61 mg) and GA (77.84 mg) with a DEE of 55.70 ± 2.15 % and R8h of 44.78 ± 0.27 %. The characterization approaches indicated the successful formation of this nanocomposite. The swelling behavior of the beads was triggered by pH change, and the drug release profile showed prolonged sustainable release that followed the Higuchi model with a non-Fickian mechanism. This nanocomposite could be a promising nanocarrier for drug loading and its controlled delivery. |
| first_indexed | 2024-03-06T13:12:54Z |
| format | Article |
| id | UMPir39986 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-03-06T13:12:54Z |
| publishDate | 2024 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | UMPir399862024-01-12T03:57:26Z http://umpir.ump.edu.my/id/eprint/39986/ Optimization of carboxymethyl cellulose-gum Arab-based hydrogel beads for anticancer drugs delivery Ghawanmeh, Abdullah A. Tan, Ling Ling Ali, Gomaa A.M. Assiri, Mohammed Ali Chong, Kwok Feng HD28 Management. Industrial Management Q Science (General) T Technology (General) Response surface methodology was successfully utilized to optimize the amounts of carboxymethyl cellulose (CMC) and gum Arab (GA) to fabricate hydrogel beads for the delivery of anticancer drugs. Drug encapsulation efficiency process (%DEE) and cumulative release (%R8h) of hydrogel beads were investigated with different amounts of CMC and GA with Fe (III) cross-linker. The numerical validation resulted in an optimized nanocomposite of CMC (99.61 mg) and GA (77.84 mg) with a DEE of 55.70 ± 2.15 % and R8h of 44.78 ± 0.27 %. The characterization approaches indicated the successful formation of this nanocomposite. The swelling behavior of the beads was triggered by pH change, and the drug release profile showed prolonged sustainable release that followed the Higuchi model with a non-Fickian mechanism. This nanocomposite could be a promising nanocarrier for drug loading and its controlled delivery. Elsevier B.V. 2024-01-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/39986/1/Optimization%20of%20carboxymethyl%20cellulose-gum%20Arab-based%20hydrogel%20beads.pdf pdf en http://umpir.ump.edu.my/id/eprint/39986/2/Optimization%20of%20carboxymethyl%20cellulose-gum%20Arab-based%20hydrogel%20beads%20for%20anticancer%20drugs%20delivery_ABS.pdf Ghawanmeh, Abdullah A. and Tan, Ling Ling and Ali, Gomaa A.M. and Assiri, Mohammed Ali and Chong, Kwok Feng (2024) Optimization of carboxymethyl cellulose-gum Arab-based hydrogel beads for anticancer drugs delivery. Journal of Molecular Liquids, 393 (123631). pp. 1-8. ISSN 0167-7322. (Published) https://doi.org/10.1016/j.molliq.2023.123631 https://doi.org/10.1016/j.molliq.2023.123631 |
| spellingShingle | HD28 Management. Industrial Management Q Science (General) T Technology (General) Ghawanmeh, Abdullah A. Tan, Ling Ling Ali, Gomaa A.M. Assiri, Mohammed Ali Chong, Kwok Feng Optimization of carboxymethyl cellulose-gum Arab-based hydrogel beads for anticancer drugs delivery |
| title | Optimization of carboxymethyl cellulose-gum Arab-based hydrogel beads for anticancer drugs delivery |
| title_full | Optimization of carboxymethyl cellulose-gum Arab-based hydrogel beads for anticancer drugs delivery |
| title_fullStr | Optimization of carboxymethyl cellulose-gum Arab-based hydrogel beads for anticancer drugs delivery |
| title_full_unstemmed | Optimization of carboxymethyl cellulose-gum Arab-based hydrogel beads for anticancer drugs delivery |
| title_short | Optimization of carboxymethyl cellulose-gum Arab-based hydrogel beads for anticancer drugs delivery |
| title_sort | optimization of carboxymethyl cellulose gum arab based hydrogel beads for anticancer drugs delivery |
| topic | HD28 Management. Industrial Management Q Science (General) T Technology (General) |
| url | http://umpir.ump.edu.my/id/eprint/39986/1/Optimization%20of%20carboxymethyl%20cellulose-gum%20Arab-based%20hydrogel%20beads.pdf http://umpir.ump.edu.my/id/eprint/39986/2/Optimization%20of%20carboxymethyl%20cellulose-gum%20Arab-based%20hydrogel%20beads%20for%20anticancer%20drugs%20delivery_ABS.pdf |
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