Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses

Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses

This study explored a series of reported 5-lipoxygenase-activating protein (FLAP) inhibitors to understand their structural requirements and identify potential new inhibitor scaffolds through automated unbiased procedures. Docking studies have revealed that inhibitor binding affinity can be influenc...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Rullah, Kamal, Roney, Miah, Zalikha, Ibrahim, Nur Farisya, Shamsudin, Deri, Islami, Qamar Uddin, Ahmed, Kok, Wai Lam, Mohd Fadhlizil Fasihi, Mohd Aluwi
Format:	Artikel
Sprache:	English
Veröffentlicht:	World Scientific Publishing 2023
Schlagworte:	Q Science (General) QD Chemistry TP Chemical technology
Online Zugang:	http://umpir.ump.edu.my/id/eprint/40039/1/Identification%20of%20novel%205-lipoxygenase-activating%20protein_abst.pdf

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