Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug
Parkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their poten...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2024
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/40087/1/Nanostarch%20based%20nanoencapsulation%20of%20Mucuna%20pruriens%20extract.pdf |
| _version_ | 1796996181672329216 |
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| author | Sardjono, Ratnaningsih Eko Gunawan, Ramdhan Kadarohman, Asep Erdiwansyah, E. Rizalman, Mamat Melati, Khairuddean |
| author_facet | Sardjono, Ratnaningsih Eko Gunawan, Ramdhan Kadarohman, Asep Erdiwansyah, E. Rizalman, Mamat Melati, Khairuddean |
| author_sort | Sardjono, Ratnaningsih Eko |
| collection | UMP |
| description | Parkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their potential as anti-Parkinsonian drug. The nanoencapsulation process was carried out by ultrasonic method. FTIR, SEM, and TEM carried out the characterization of NS-MPn and NS-MD-MPn nanocapsules. Encapsulation efficiency was evaluated by UV-Vis spectroscopy. SEM and TEM characterization NS-MPn and NS-MD-MPn nanocapsules have non-spherical surface morphology, spherical in shape 234.98 and 90.85 nm, respectively. NS-MPn have 21.35% encapsulation efficiency, meanwhile, NS-MD-MPn has 30.02%. |
| first_indexed | 2024-03-06T13:13:11Z |
| format | Article |
| id | UMPir40087 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T13:13:11Z |
| publishDate | 2024 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | UMPir400872024-01-18T06:38:45Z http://umpir.ump.edu.my/id/eprint/40087/ Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug Sardjono, Ratnaningsih Eko Gunawan, Ramdhan Kadarohman, Asep Erdiwansyah, E. Rizalman, Mamat Melati, Khairuddean T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics Parkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their potential as anti-Parkinsonian drug. The nanoencapsulation process was carried out by ultrasonic method. FTIR, SEM, and TEM carried out the characterization of NS-MPn and NS-MD-MPn nanocapsules. Encapsulation efficiency was evaluated by UV-Vis spectroscopy. SEM and TEM characterization NS-MPn and NS-MD-MPn nanocapsules have non-spherical surface morphology, spherical in shape 234.98 and 90.85 nm, respectively. NS-MPn have 21.35% encapsulation efficiency, meanwhile, NS-MD-MPn has 30.02%. Elsevier Ltd 2024-06 Article PeerReviewed pdf en cc_by_nc_nd_4 http://umpir.ump.edu.my/id/eprint/40087/1/Nanostarch%20based%20nanoencapsulation%20of%20Mucuna%20pruriens%20extract.pdf Sardjono, Ratnaningsih Eko and Gunawan, Ramdhan and Kadarohman, Asep and Erdiwansyah, E. and Rizalman, Mamat and Melati, Khairuddean (2024) Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug. Case Studies in Chemical and Environmental Engineering, 9 (100562). pp. 1-9. ISSN 2666-0164. (Published) https://doi.org/10.1016/j.cscee.2023.100562 https://doi.org/10.1016/j.cscee.2023.100562 |
| spellingShingle | T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics Sardjono, Ratnaningsih Eko Gunawan, Ramdhan Kadarohman, Asep Erdiwansyah, E. Rizalman, Mamat Melati, Khairuddean Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_full | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_fullStr | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_full_unstemmed | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_short | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_sort | nanostarch based nanoencapsulation of mucuna pruriens extract and its evaluation as anti parkinsonian drug |
| topic | T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics |
| url | http://umpir.ump.edu.my/id/eprint/40087/1/Nanostarch%20based%20nanoencapsulation%20of%20Mucuna%20pruriens%20extract.pdf |
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