Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies
A metabolic condition known as diabetes mellitus is characterized by hyperglycemia brought on by either inadequate insulin production, resistance to insulin action, or both. The anti-diabetic medications that are now on the market either impact how much glucose is absorbed and excreted or how much i...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Eurasian Science Society (ESS)
2023
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/40302/1/Anti-diabetic%20Activity%20of%20Phloretin%20Against%20Maltase-glucoamylase.pdf |
| _version_ | 1796996221793992704 |
|---|---|
| author | Roney, Miah Mohd Fadhlizil Fasihi, Mohd Aluwi |
| author_facet | Roney, Miah Mohd Fadhlizil Fasihi, Mohd Aluwi |
| author_sort | Roney, Miah |
| collection | UMP |
| description | A metabolic condition known as diabetes mellitus is characterized by hyperglycemia brought on by either inadequate insulin production, resistance to insulin action, or both. The anti-diabetic medications that are now on the market either impact how much glucose is absorbed and excreted or how much insulin is secreted without affecting insulin resistance. This study used in-silico methods to assess the efficacy of phloretin as anti-diabetic drug against maltase-glucoamylase. Phloretin displayed strong binding to the maltase-glucoamylase protein with good docking scores (-7.4 kcal/mol), as opposed to co-crystallized ligand (-6.2 kcal/mol). In terms of physicochemical qualities, drug-likeness, and medicinal chemistry properties, Phloretin also performed best. The results of molecular docking and data acquired from pharmacokinetic characteristics of phloretin may be used further for the creation of newer maltase-glucoamylases with potential anti-diabetic properties and improved pharmacokinetic profiles. |
| first_indexed | 2024-03-06T13:13:47Z |
| format | Article |
| id | UMPir40302 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T13:13:47Z |
| publishDate | 2023 |
| publisher | Eurasian Science Society (ESS) |
| record_format | dspace |
| spelling | UMPir403022024-02-08T07:11:25Z http://umpir.ump.edu.my/id/eprint/40302/ Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies Roney, Miah Mohd Fadhlizil Fasihi, Mohd Aluwi Q Science (General) TP Chemical technology A metabolic condition known as diabetes mellitus is characterized by hyperglycemia brought on by either inadequate insulin production, resistance to insulin action, or both. The anti-diabetic medications that are now on the market either impact how much glucose is absorbed and excreted or how much insulin is secreted without affecting insulin resistance. This study used in-silico methods to assess the efficacy of phloretin as anti-diabetic drug against maltase-glucoamylase. Phloretin displayed strong binding to the maltase-glucoamylase protein with good docking scores (-7.4 kcal/mol), as opposed to co-crystallized ligand (-6.2 kcal/mol). In terms of physicochemical qualities, drug-likeness, and medicinal chemistry properties, Phloretin also performed best. The results of molecular docking and data acquired from pharmacokinetic characteristics of phloretin may be used further for the creation of newer maltase-glucoamylases with potential anti-diabetic properties and improved pharmacokinetic profiles. Eurasian Science Society (ESS) 2023-10 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/40302/1/Anti-diabetic%20Activity%20of%20Phloretin%20Against%20Maltase-glucoamylase.pdf Roney, Miah and Mohd Fadhlizil Fasihi, Mohd Aluwi (2023) Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies. Journal of Chemistry Letters, 4. pp. 164-170. ISSN 2717-1892. (Published) https://doi.org/10.22034/JCHEMLETT.2023.411216.1131 https://doi.org/10.22034/JCHEMLETT.2023.411216.1131 |
| spellingShingle | Q Science (General) TP Chemical technology Roney, Miah Mohd Fadhlizil Fasihi, Mohd Aluwi Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies |
| title | Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies |
| title_full | Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies |
| title_fullStr | Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies |
| title_full_unstemmed | Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies |
| title_short | Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies |
| title_sort | anti diabetic activity of phloretin against maltase glucoamylase using docking pharmacokinetics and pharmacophore studies |
| topic | Q Science (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/40302/1/Anti-diabetic%20Activity%20of%20Phloretin%20Against%20Maltase-glucoamylase.pdf |
| work_keys_str_mv | AT roneymiah antidiabeticactivityofphloretinagainstmaltaseglucoamylaseusingdockingpharmacokineticsandpharmacophorestudies AT mohdfadhlizilfasihimohdaluwi antidiabeticactivityofphloretinagainstmaltaseglucoamylaseusingdockingpharmacokineticsandpharmacophorestudies |