Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach
Antimicrobial drug resistance (AMR) is a severe global threat to public health. The increasing emergence of drug-resistant bacteria requires the discovery of novel antibacterial agents. Quinoline derivatives have previously been reported to exhibit antimalarial, antiviral, antitumor, antiulcer, anti...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Taylor and Francis Ltd.
2023
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| Online Access: | http://umpir.ump.edu.my/id/eprint/40528/1/Evaluation%20of%20potential%20bacterial%20protease%20inhibitor%20properties.pdf http://umpir.ump.edu.my/id/eprint/40528/2/Evaluation%20of%20potential%20bacterial%20protease%20inhibitor%20properties%20of%20selected%20hydroxyquinoline%20derivatives_ABS.pdf |
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| author | Riaz, Faiza Hossain, Md Sanower Roney, Miah Ali, Yousaf Qureshi, Saira Muhammad, Riaz Moshawih, Said Shafida, Abd Hamid Seidel, Veronique Ur Rashid, Haroon Long, Chiau Ming |
| author_facet | Riaz, Faiza Hossain, Md Sanower Roney, Miah Ali, Yousaf Qureshi, Saira Muhammad, Riaz Moshawih, Said Shafida, Abd Hamid Seidel, Veronique Ur Rashid, Haroon Long, Chiau Ming |
| author_sort | Riaz, Faiza |
| collection | UMP |
| description | Antimicrobial drug resistance (AMR) is a severe global threat to public health. The increasing emergence of drug-resistant bacteria requires the discovery of novel antibacterial agents. Quinoline derivatives have previously been reported to exhibit antimalarial, antiviral, antitumor, antiulcer, antioxidant and, most interestingly, antibacterial properties. In this study, we evaluated the binding affinity of three newly designed hydroxyquinolines derived from sulfanilamide (1), 4-amino benzoic acid (2) and sulfanilic acid (3) towards five bacterial protein targets (PDB ID: 1JIJ, 3VOB, 1ZI0, 6F86, 4CJN). The three derivatives were designed considering the amino acid residues identified at the active site of each protein involved in the binding of each co-crystallized ligand and drug-likeness properties. The ligands displayed binding energy values with the target proteins ranging from −2.17 to −8.45 kcal/mol. Compounds (1) and (3) showed the best binding scores towards 1ZI0/3VOB and 1JIJ/4CJN, respectively, which may serve as new antibiotic scaffolds. Our in silico results suggest that sulfanilamide (1) or sulfanilic acid (3) hydroxyquinoline derivatives have the potential to be developed as bacterial inhibitors, particularly MRSA inhibitors. But before that, it must go through the proper preclinical and clinical trials for further scientific validation. Further experimental studies are warranted to explore the antibacterial potential of these compounds through preclinical and clinical studies. Communicated by Ramaswamy H. Sarma. |
| first_indexed | 2024-09-25T03:48:09Z |
| format | Article |
| id | UMPir40528 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-09-25T03:48:09Z |
| publishDate | 2023 |
| publisher | Taylor and Francis Ltd. |
| record_format | dspace |
| spelling | UMPir405282024-04-30T06:30:16Z http://umpir.ump.edu.my/id/eprint/40528/ Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach Riaz, Faiza Hossain, Md Sanower Roney, Miah Ali, Yousaf Qureshi, Saira Muhammad, Riaz Moshawih, Said Shafida, Abd Hamid Seidel, Veronique Ur Rashid, Haroon Long, Chiau Ming HD Industries. Land use. Labor Q Science (General) SH Aquaculture. Fisheries. Angling T Technology (General) TD Environmental technology. Sanitary engineering Antimicrobial drug resistance (AMR) is a severe global threat to public health. The increasing emergence of drug-resistant bacteria requires the discovery of novel antibacterial agents. Quinoline derivatives have previously been reported to exhibit antimalarial, antiviral, antitumor, antiulcer, antioxidant and, most interestingly, antibacterial properties. In this study, we evaluated the binding affinity of three newly designed hydroxyquinolines derived from sulfanilamide (1), 4-amino benzoic acid (2) and sulfanilic acid (3) towards five bacterial protein targets (PDB ID: 1JIJ, 3VOB, 1ZI0, 6F86, 4CJN). The three derivatives were designed considering the amino acid residues identified at the active site of each protein involved in the binding of each co-crystallized ligand and drug-likeness properties. The ligands displayed binding energy values with the target proteins ranging from −2.17 to −8.45 kcal/mol. Compounds (1) and (3) showed the best binding scores towards 1ZI0/3VOB and 1JIJ/4CJN, respectively, which may serve as new antibiotic scaffolds. Our in silico results suggest that sulfanilamide (1) or sulfanilic acid (3) hydroxyquinoline derivatives have the potential to be developed as bacterial inhibitors, particularly MRSA inhibitors. But before that, it must go through the proper preclinical and clinical trials for further scientific validation. Further experimental studies are warranted to explore the antibacterial potential of these compounds through preclinical and clinical studies. Communicated by Ramaswamy H. Sarma. Taylor and Francis Ltd. 2023 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/40528/1/Evaluation%20of%20potential%20bacterial%20protease%20inhibitor%20properties.pdf pdf en http://umpir.ump.edu.my/id/eprint/40528/2/Evaluation%20of%20potential%20bacterial%20protease%20inhibitor%20properties%20of%20selected%20hydroxyquinoline%20derivatives_ABS.pdf Riaz, Faiza and Hossain, Md Sanower and Roney, Miah and Ali, Yousaf and Qureshi, Saira and Muhammad, Riaz and Moshawih, Said and Shafida, Abd Hamid and Seidel, Veronique and Ur Rashid, Haroon and Long, Chiau Ming (2023) Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach. Journal of Biomolecular Structure and Dynamics, 41 (19). pp. 9756-9769. ISSN 0739-1102. (Published) https://doi.org/10.1080/07391102.2022.2146200 https://doi.org/10.1080/07391102.2022.2146200 |
| spellingShingle | HD Industries. Land use. Labor Q Science (General) SH Aquaculture. Fisheries. Angling T Technology (General) TD Environmental technology. Sanitary engineering Riaz, Faiza Hossain, Md Sanower Roney, Miah Ali, Yousaf Qureshi, Saira Muhammad, Riaz Moshawih, Said Shafida, Abd Hamid Seidel, Veronique Ur Rashid, Haroon Long, Chiau Ming Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach |
| title | Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach |
| title_full | Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach |
| title_fullStr | Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach |
| title_full_unstemmed | Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach |
| title_short | Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach |
| title_sort | evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives an in silico docking and molecular dynamics simulation approach |
| topic | HD Industries. Land use. Labor Q Science (General) SH Aquaculture. Fisheries. Angling T Technology (General) TD Environmental technology. Sanitary engineering |
| url | http://umpir.ump.edu.my/id/eprint/40528/1/Evaluation%20of%20potential%20bacterial%20protease%20inhibitor%20properties.pdf http://umpir.ump.edu.my/id/eprint/40528/2/Evaluation%20of%20potential%20bacterial%20protease%20inhibitor%20properties%20of%20selected%20hydroxyquinoline%20derivatives_ABS.pdf |
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