Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults
Uncontrolled hypertension is one of the recognized risk factors for coronary artery disease (CAD) in young adults, commonly underestimated owing to the young age. A novel biomarker to improve CAD risk assessment and hypertension management should be identified for this cohort. Thus, we had conducted...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
International Islamic University Malaysia
2024
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/41279/1/Plasma%20haptoglobin%20as%20a%20potential%20biomarker%20for%20coronary%20artery%20disease.pdf http://umpir.ump.edu.my/id/eprint/41279/2/Plasma%20haptoglobin%20as%20A%20potential%20biomarker%20for%20coronary%20artery%20disease%20in%20young%20hypertensive%20adults_Abs.pdf |
| Summary: | Uncontrolled hypertension is one of the recognized risk factors for coronary artery disease (CAD) in young adults, commonly underestimated owing to the young age. A novel biomarker to improve CAD risk assessment and hypertension management should be identified for this cohort. Thus, we had conducted a study to investigate plasma concentration and the role of haptoglobin in young hypertensive adults in the establishment of premature acute myocardial infarction (AMI). MATERIALS AND METHODS: A total of 120 male adults aged between 18 to 45 years enrolled into this cross-sectional study, divided into control, hypertensive, and acute myocardial infarction (AMI) groups. Blood samples were collected from all subjects, plasma concentrations of haptoglobin measured using enzyme-linked immunosorbent assays, and other CAD risk factors including high sensitivity C-reactive protein (hs-CRP) levels were analyzed. RESULTS: Plasma concentration of haptoglobin in the AMI group was the highest compared to hypertensive and control group (290.63±99.90 vs. 208.47±112.93 vs. 170.02±108.11 ng/ml, p<0.006). There was a significant association between AMI and plasma haptoglobin concentration in hypertensive subjects independent of other known CAD risk factors (OR: 0.985, 95% CI 0.973-0.997, p=0.017). There was positive correlation between plasma haptoglobin and hs-CRP (r=0.0370, p<0.001). CONCLUSION: Plasma haptoglobin is a potential biomarker to identify young hypertensive adults who are at risk of developing CAD. |
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