Aptamer‑functionalized MOFs and AI‑driven strategies for early cancer diagnosis and therapeutics
Metal–Organic Frameworks (MOFs) have exceptional inherent properties that make them highly suitable for diverse applications, such as catalysis, storage, optics, chemo sensing, and biomedical science and technology. Over the past decades, researchers have utilized various techniques, including solvo...
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| Format: | Article |
| Language: | English English |
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Springer Science and Business Media B.V.
2024
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| Online Access: | http://umpir.ump.edu.my/id/eprint/41289/1/Aptamer-functionalized%20MOFs%20and%20AI-driven%20strategies%20for%20early%20cancer.pdf http://umpir.ump.edu.my/id/eprint/41289/2/Aptamer%E2%80%91functionalized%20MOFs%20and%20AI%E2%80%91driven%20strategies%20for%20early%20cancer%20diagnosis%20and%20therapeutics_ABS.pdf |
| _version_ | 1811138395368325120 |
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| author | Futane, Abhishek Jadhav, Pramod Mustafa, Abu Hasnat Srinivasan, Arthi Narayanamurthy, Vigneswaran |
| author_facet | Futane, Abhishek Jadhav, Pramod Mustafa, Abu Hasnat Srinivasan, Arthi Narayanamurthy, Vigneswaran |
| author_sort | Futane, Abhishek |
| collection | UMP |
| description | Metal–Organic Frameworks (MOFs) have exceptional inherent properties that make them highly suitable for diverse applications, such as catalysis, storage, optics, chemo sensing, and biomedical science and technology. Over the past decades, researchers have utilized various techniques, including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasonic, to synthesize MOFs with tailored properties. Post-synthetic modification of linkers, nodal components, and crystallite domain size and morphology can functionalize MOFs to improve their aptamer applications. Advancements in AI and machine learning led to the development of nonporous MOFs and nanoscale MOFs for medical purposes. MOFs have exhibited promise in cancer therapy, with the successful accumulation of a photosensitizer in cancer cells representing a significant breakthrough. This perspective is focused on MOFs' use as advanced materials and systems for cancer therapy, exploring the challenging aspects and promising features of MOF-based cancer diagnosis and treatment. The paper concludes by emphasizing the potential of MOFs as a transformative technology for cancer treatment and diagnosis. |
| first_indexed | 2024-09-25T03:49:31Z |
| format | Article |
| id | UMPir41289 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-09-25T03:49:31Z |
| publishDate | 2024 |
| publisher | Springer Science and Business Media B.V. |
| record_format | dspace |
| spelling | UMPir412892024-06-10T03:12:37Z http://umpir.ump.edu.my/id/eprint/41289/ Aptamer‑functionalized MOFs and AI‑driven strategies for early cancer diagnosis and therapeutics Futane, Abhishek Jadhav, Pramod Mustafa, Abu Hasnat Srinivasan, Arthi Narayanamurthy, Vigneswaran Q Science (General) QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Metal–Organic Frameworks (MOFs) have exceptional inherent properties that make them highly suitable for diverse applications, such as catalysis, storage, optics, chemo sensing, and biomedical science and technology. Over the past decades, researchers have utilized various techniques, including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasonic, to synthesize MOFs with tailored properties. Post-synthetic modification of linkers, nodal components, and crystallite domain size and morphology can functionalize MOFs to improve their aptamer applications. Advancements in AI and machine learning led to the development of nonporous MOFs and nanoscale MOFs for medical purposes. MOFs have exhibited promise in cancer therapy, with the successful accumulation of a photosensitizer in cancer cells representing a significant breakthrough. This perspective is focused on MOFs' use as advanced materials and systems for cancer therapy, exploring the challenging aspects and promising features of MOF-based cancer diagnosis and treatment. The paper concludes by emphasizing the potential of MOFs as a transformative technology for cancer treatment and diagnosis. Springer Science and Business Media B.V. 2024-02 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/41289/1/Aptamer-functionalized%20MOFs%20and%20AI-driven%20strategies%20for%20early%20cancer.pdf pdf en http://umpir.ump.edu.my/id/eprint/41289/2/Aptamer%E2%80%91functionalized%20MOFs%20and%20AI%E2%80%91driven%20strategies%20for%20early%20cancer%20diagnosis%20and%20therapeutics_ABS.pdf Futane, Abhishek and Jadhav, Pramod and Mustafa, Abu Hasnat and Srinivasan, Arthi and Narayanamurthy, Vigneswaran (2024) Aptamer‑functionalized MOFs and AI‑driven strategies for early cancer diagnosis and therapeutics. Biotechnology Letters, 46 (1). pp. 1-17. ISSN 0141-5492. (Published) https://doi.org/10.1007/s10529-023-03454-z https://doi.org/10.1007/s10529-023-03454-z |
| spellingShingle | Q Science (General) QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Futane, Abhishek Jadhav, Pramod Mustafa, Abu Hasnat Srinivasan, Arthi Narayanamurthy, Vigneswaran Aptamer‑functionalized MOFs and AI‑driven strategies for early cancer diagnosis and therapeutics |
| title | Aptamer‑functionalized MOFs and AI‑driven strategies for early cancer diagnosis and therapeutics |
| title_full | Aptamer‑functionalized MOFs and AI‑driven strategies for early cancer diagnosis and therapeutics |
| title_fullStr | Aptamer‑functionalized MOFs and AI‑driven strategies for early cancer diagnosis and therapeutics |
| title_full_unstemmed | Aptamer‑functionalized MOFs and AI‑driven strategies for early cancer diagnosis and therapeutics |
| title_short | Aptamer‑functionalized MOFs and AI‑driven strategies for early cancer diagnosis and therapeutics |
| title_sort | aptamer functionalized mofs and ai driven strategies for early cancer diagnosis and therapeutics |
| topic | Q Science (General) QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/41289/1/Aptamer-functionalized%20MOFs%20and%20AI-driven%20strategies%20for%20early%20cancer.pdf http://umpir.ump.edu.my/id/eprint/41289/2/Aptamer%E2%80%91functionalized%20MOFs%20and%20AI%E2%80%91driven%20strategies%20for%20early%20cancer%20diagnosis%20and%20therapeutics_ABS.pdf |
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