Modelling the effect of ischemia on myocardial electrophysiology
Myocardial infarction (MI), also known as a heart attack is one of the lifelong chronic diseases that can give a permanent damage to the heart muscle. This creates a disruption of oxygen supply to the myocardium that could lead to arrhythmia. However, the underlying mechanism that relate MI and arrh...
| Main Authors: | , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
IET
2022
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/41954/1/Modelling%20the%20effect%20of%20ischemia%20on%20myocardial%20electrophysiology.pdf |
| _version_ | 1825815788258328576 |
|---|---|
| author | P. N. A. Nasuha, Mohd Nor Mohd Jamil, Mohamed Mokhtarudin |
| author_facet | P. N. A. Nasuha, Mohd Nor Mohd Jamil, Mohamed Mokhtarudin |
| author_sort | P. N. A. Nasuha, Mohd Nor |
| collection | UMP |
| description | Myocardial infarction (MI), also known as a heart attack is one of the lifelong chronic diseases that can give a permanent damage to the heart muscle. This creates a disruption of oxygen supply to the myocardium that could lead to arrhythmia. However, the underlying mechanism that relate MI and arrhythmia is difficult to be described. In this study, a mathematical model to investigate the relationship between MI and arrhythmia is developed using the oxygen diffusion model coupled with the myocardium electrophysiological model based on the work by Ten Tusscher et al. Four levels of ischemia are simulated by modifying the initial oxygen percentage, which are reduced by 10%, 40%, 50%, and 90%. From the simulations, the myocardium electrophysiology is affected by the reduction of oxygen and validated some of the findings from previous clinical works. It is also found that a larger oxygen reduction within the myocardium causes overload of intracellular sodium and calcium ions, which has been previously studied that this could potentially give higher risk of myocardial injury. In addition, oxygen reduction in myocardium causes changes in the morphology of the action potential, which could initiate arrhythmia post-ischemia. |
| first_indexed | 2024-09-25T03:51:32Z |
| format | Conference or Workshop Item |
| id | UMPir41954 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-09-25T03:51:32Z |
| publishDate | 2022 |
| publisher | IET |
| record_format | dspace |
| spelling | UMPir419542024-07-16T05:00:04Z http://umpir.ump.edu.my/id/eprint/41954/ Modelling the effect of ischemia on myocardial electrophysiology P. N. A. Nasuha, Mohd Nor Mohd Jamil, Mohamed Mokhtarudin TJ Mechanical engineering and machinery TS Manufactures Myocardial infarction (MI), also known as a heart attack is one of the lifelong chronic diseases that can give a permanent damage to the heart muscle. This creates a disruption of oxygen supply to the myocardium that could lead to arrhythmia. However, the underlying mechanism that relate MI and arrhythmia is difficult to be described. In this study, a mathematical model to investigate the relationship between MI and arrhythmia is developed using the oxygen diffusion model coupled with the myocardium electrophysiological model based on the work by Ten Tusscher et al. Four levels of ischemia are simulated by modifying the initial oxygen percentage, which are reduced by 10%, 40%, 50%, and 90%. From the simulations, the myocardium electrophysiology is affected by the reduction of oxygen and validated some of the findings from previous clinical works. It is also found that a larger oxygen reduction within the myocardium causes overload of intracellular sodium and calcium ions, which has been previously studied that this could potentially give higher risk of myocardial injury. In addition, oxygen reduction in myocardium causes changes in the morphology of the action potential, which could initiate arrhythmia post-ischemia. IET 2022 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/41954/1/Modelling%20the%20effect%20of%20ischemia%20on%20myocardial%20electrophysiology.pdf P. N. A. Nasuha, Mohd Nor and Mohd Jamil, Mohamed Mokhtarudin (2022) Modelling the effect of ischemia on myocardial electrophysiology. In: IET Conference Proceedings. IET Conference Proceedings; 2022 Engineering Technology International Conference, ETIC 2022 , 07 - 08 September 2022 , Pahang, Virtual. 498 -503., 2022 (22). ISSN 2732-4494 ISBN 978-183953782-0 (Published) https://doi.org/10.1049/icp.2022.2671 |
| spellingShingle | TJ Mechanical engineering and machinery TS Manufactures P. N. A. Nasuha, Mohd Nor Mohd Jamil, Mohamed Mokhtarudin Modelling the effect of ischemia on myocardial electrophysiology |
| title | Modelling the effect of ischemia on myocardial electrophysiology |
| title_full | Modelling the effect of ischemia on myocardial electrophysiology |
| title_fullStr | Modelling the effect of ischemia on myocardial electrophysiology |
| title_full_unstemmed | Modelling the effect of ischemia on myocardial electrophysiology |
| title_short | Modelling the effect of ischemia on myocardial electrophysiology |
| title_sort | modelling the effect of ischemia on myocardial electrophysiology |
| topic | TJ Mechanical engineering and machinery TS Manufactures |
| url | http://umpir.ump.edu.my/id/eprint/41954/1/Modelling%20the%20effect%20of%20ischemia%20on%20myocardial%20electrophysiology.pdf |
| work_keys_str_mv | AT pnanasuhamohdnor modellingtheeffectofischemiaonmyocardialelectrophysiology AT mohdjamilmohamedmokhtarudin modellingtheeffectofischemiaonmyocardialelectrophysiology |