Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke
Brain oedema or tissue swelling that develops after ischaemic stroke can cause detrimental effects, including brain herniation and increased intracranial pressure (ICP). These effects can be reduced by performing a decompressive craniectomy (DC) operation, in which a portion of the skull is removed...
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| Format: | Article |
| Language: | English English |
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Taylor and Francis Ltd.
2024
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| Online Access: | http://umpir.ump.edu.my/id/eprint/41979/1/Poroelastic%20modelling%20of%20brain%20tissue%20swelling_ABST.pdf http://umpir.ump.edu.my/id/eprint/41979/2/Poroelastic%20modelling%20of%20brain%20tissue%20swelling.pdf |
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| author | Aina Najwa, Nadzri Nik Abdullah, Nik Mohamed Payne, Stephen J. Mohd Jamil, Mohamed Mokhtarudin |
| author_facet | Aina Najwa, Nadzri Nik Abdullah, Nik Mohamed Payne, Stephen J. Mohd Jamil, Mohamed Mokhtarudin |
| author_sort | Aina Najwa, Nadzri |
| collection | UMP |
| description | Brain oedema or tissue swelling that develops after ischaemic stroke can cause detrimental effects, including brain herniation and increased intracranial pressure (ICP). These effects can be reduced by performing a decompressive craniectomy (DC) operation, in which a portion of the skull is removed to allow swollen brain tissue to expand outside the skull. In this study, a poroelastic model is used to investigate the effect of brain ischaemic infarct size and location on the severity of brain tissue swelling. Furthermore, the model will also be used to evaluate the effectiveness of DC surgery as a treatment for brain tissue swelling after ischaemia. The poroelastic model consists of two equations: one describing the elasticity of the brain tissue and the other describing the changes in the interstitial tissue pressure. The model is applied on an idealized brain geometry, and it is found that infarcts with radius larger than approximately 14 mm and located near the lateral ventricle produce worse brain midline shift, measured through lateral ventricle compression. Furthermore, the model is also able to show the positive effect of DC treatment in reducing the brain midline shift by allowing part of the brain tissue to expand through the skull opening. However, the model does not show a decrease in the interstitial pressure during DC treatment. Further improvement and validation could enhance the capability of the proposed poroelastic model in predicting the occurrence of brain tissue swelling and DC treatment post ischaemia. |
| first_indexed | 2024-09-25T03:51:36Z |
| format | Article |
| id | UMPir41979 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-09-25T03:51:36Z |
| publishDate | 2024 |
| publisher | Taylor and Francis Ltd. |
| record_format | dspace |
| spelling | UMPir419792024-07-17T04:40:53Z http://umpir.ump.edu.my/id/eprint/41979/ Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke Aina Najwa, Nadzri Nik Abdullah, Nik Mohamed Payne, Stephen J. Mohd Jamil, Mohamed Mokhtarudin QA75 Electronic computers. Computer science TS Manufactures Brain oedema or tissue swelling that develops after ischaemic stroke can cause detrimental effects, including brain herniation and increased intracranial pressure (ICP). These effects can be reduced by performing a decompressive craniectomy (DC) operation, in which a portion of the skull is removed to allow swollen brain tissue to expand outside the skull. In this study, a poroelastic model is used to investigate the effect of brain ischaemic infarct size and location on the severity of brain tissue swelling. Furthermore, the model will also be used to evaluate the effectiveness of DC surgery as a treatment for brain tissue swelling after ischaemia. The poroelastic model consists of two equations: one describing the elasticity of the brain tissue and the other describing the changes in the interstitial tissue pressure. The model is applied on an idealized brain geometry, and it is found that infarcts with radius larger than approximately 14 mm and located near the lateral ventricle produce worse brain midline shift, measured through lateral ventricle compression. Furthermore, the model is also able to show the positive effect of DC treatment in reducing the brain midline shift by allowing part of the brain tissue to expand through the skull opening. However, the model does not show a decrease in the interstitial pressure during DC treatment. Further improvement and validation could enhance the capability of the proposed poroelastic model in predicting the occurrence of brain tissue swelling and DC treatment post ischaemia. Taylor and Francis Ltd. 2024-03-10 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/41979/1/Poroelastic%20modelling%20of%20brain%20tissue%20swelling_ABST.pdf pdf en http://umpir.ump.edu.my/id/eprint/41979/2/Poroelastic%20modelling%20of%20brain%20tissue%20swelling.pdf Aina Najwa, Nadzri and Nik Abdullah, Nik Mohamed and Payne, Stephen J. and Mohd Jamil, Mohamed Mokhtarudin (2024) Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke. Computer Methods in Biomechanics and Biomedical Engineering. pp. 1-12. ISSN 1025-5842. (In Press / Online First) (In Press / Online First) https://doi.org/10.1080/10255842.2024.2326972 https://doi.org/10.1080/10255842.2024.2326972 |
| spellingShingle | QA75 Electronic computers. Computer science TS Manufactures Aina Najwa, Nadzri Nik Abdullah, Nik Mohamed Payne, Stephen J. Mohd Jamil, Mohamed Mokhtarudin Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke |
| title | Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke |
| title_full | Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke |
| title_fullStr | Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke |
| title_full_unstemmed | Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke |
| title_short | Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke |
| title_sort | poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke |
| topic | QA75 Electronic computers. Computer science TS Manufactures |
| url | http://umpir.ump.edu.my/id/eprint/41979/1/Poroelastic%20modelling%20of%20brain%20tissue%20swelling_ABST.pdf http://umpir.ump.edu.my/id/eprint/41979/2/Poroelastic%20modelling%20of%20brain%20tissue%20swelling.pdf |
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