Crosstalk Between Coagulopathy and Inflammation in Obesity-Related Severe COVID-19 Infection
Abstract: Obesity is among the most prevalent risk factors in the severe forms of Coronavirus disease 2019 (COVID-19) infection. COVID-19 patients with obesity often face severe complications that might be associated with overexpression of adiponectin, inflammatory cytokines, and angiotensin convert...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2025
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/43906/1/hemato-06-00004-v2.pdf |
| _version_ | 1825816147060064256 |
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| author | Talebabadi, Nazanin Eusni Rahayu, Mohd Tohit Abdullah, Maha Siti Yazmin, Zahari Sham Nur Fatin Zalikha, Zailan Syafinaz, Amin Nordin Irmi Zarina, Ismail Ahmad Mahfuz, Gazali Masriana, Hassan |
| author_facet | Talebabadi, Nazanin Eusni Rahayu, Mohd Tohit Abdullah, Maha Siti Yazmin, Zahari Sham Nur Fatin Zalikha, Zailan Syafinaz, Amin Nordin Irmi Zarina, Ismail Ahmad Mahfuz, Gazali Masriana, Hassan |
| author_sort | Talebabadi, Nazanin |
| collection | UMP |
| description | Abstract: Obesity is among the most prevalent risk factors in the severe forms of Coronavirus disease 2019 (COVID-19) infection. COVID-19 patients with obesity often face severe complications that might be associated with overexpression of adiponectin, inflammatory cytokines, and angiotensin converting enzyme 2 (ACE2) receptors in visceral fat. The pre-existing subclinical inflammation associated with obesity can also lead to severe inflammatory responses. Elevation of proinflammatory cytokines considerably activates coagulation cascades, including the tissue factor (TF) pathway. The hypercoagulable state in COVID-19 is presented with severe pulmonary complications such as venous thromboembolism (VTE), disseminated intravascular coagulation (DIC), and disruption of vascular endothelial cells, which can lead to severe complications and death. The interaction between inflammatory response and coagulation mechanism in COVID-19 patients with obesity warrants a further understanding of prognosis and potential therapeutic approaches. This review discusses the crosstalk between inflammation and coagulopathy in obesity-related severe COVID-19 infection. |
| first_indexed | 2025-03-06T04:06:05Z |
| format | Article |
| id | UMPir43906 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2025-03-06T04:06:05Z |
| publishDate | 2025 |
| publisher | MDPI |
| record_format | dspace |
| spelling | UMPir439062025-02-26T04:37:22Z http://umpir.ump.edu.my/id/eprint/43906/ Crosstalk Between Coagulopathy and Inflammation in Obesity-Related Severe COVID-19 Infection Talebabadi, Nazanin Eusni Rahayu, Mohd Tohit Abdullah, Maha Siti Yazmin, Zahari Sham Nur Fatin Zalikha, Zailan Syafinaz, Amin Nordin Irmi Zarina, Ismail Ahmad Mahfuz, Gazali Masriana, Hassan Q Science (General) RZ Other systems of medicine Abstract: Obesity is among the most prevalent risk factors in the severe forms of Coronavirus disease 2019 (COVID-19) infection. COVID-19 patients with obesity often face severe complications that might be associated with overexpression of adiponectin, inflammatory cytokines, and angiotensin converting enzyme 2 (ACE2) receptors in visceral fat. The pre-existing subclinical inflammation associated with obesity can also lead to severe inflammatory responses. Elevation of proinflammatory cytokines considerably activates coagulation cascades, including the tissue factor (TF) pathway. The hypercoagulable state in COVID-19 is presented with severe pulmonary complications such as venous thromboembolism (VTE), disseminated intravascular coagulation (DIC), and disruption of vascular endothelial cells, which can lead to severe complications and death. The interaction between inflammatory response and coagulation mechanism in COVID-19 patients with obesity warrants a further understanding of prognosis and potential therapeutic approaches. This review discusses the crosstalk between inflammation and coagulopathy in obesity-related severe COVID-19 infection. MDPI 2025-02-14 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/43906/1/hemato-06-00004-v2.pdf Talebabadi, Nazanin and Eusni Rahayu, Mohd Tohit and Abdullah, Maha and Siti Yazmin, Zahari Sham and Nur Fatin Zalikha, Zailan and Syafinaz, Amin Nordin and Irmi Zarina, Ismail and Ahmad Mahfuz, Gazali and Masriana, Hassan (2025) Crosstalk Between Coagulopathy and Inflammation in Obesity-Related Severe COVID-19 Infection. Hemato, 6 (4). pp. 1-16. ISSN 2673-6357. (Published) https://doi.org/10.3390/hemato6010004 https://doi.org/10.3390/hemato6010004 |
| spellingShingle | Q Science (General) RZ Other systems of medicine Talebabadi, Nazanin Eusni Rahayu, Mohd Tohit Abdullah, Maha Siti Yazmin, Zahari Sham Nur Fatin Zalikha, Zailan Syafinaz, Amin Nordin Irmi Zarina, Ismail Ahmad Mahfuz, Gazali Masriana, Hassan Crosstalk Between Coagulopathy and Inflammation in Obesity-Related Severe COVID-19 Infection |
| title | Crosstalk Between Coagulopathy and Inflammation in
Obesity-Related Severe COVID-19 Infection |
| title_full | Crosstalk Between Coagulopathy and Inflammation in
Obesity-Related Severe COVID-19 Infection |
| title_fullStr | Crosstalk Between Coagulopathy and Inflammation in
Obesity-Related Severe COVID-19 Infection |
| title_full_unstemmed | Crosstalk Between Coagulopathy and Inflammation in
Obesity-Related Severe COVID-19 Infection |
| title_short | Crosstalk Between Coagulopathy and Inflammation in
Obesity-Related Severe COVID-19 Infection |
| title_sort | crosstalk between coagulopathy and inflammation in obesity related severe covid 19 infection |
| topic | Q Science (General) RZ Other systems of medicine |
| url | http://umpir.ump.edu.my/id/eprint/43906/1/hemato-06-00004-v2.pdf |
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