Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release
To evaluate the antidiabetic properties of borapetol B known as compound 1 (C1) isolated from Tinospora crispa in normoglycemic control Wistar (W) and spontaneously type 2 diabetic Goto-Kakizaki (GK) rats. Methods. The effect of C1 on blood glucose and plasma insulin was assessed by an oral glucose...
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| Format: | Article |
| Language: | English |
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2013
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| Online Access: | http://umpir.ump.edu.my/id/eprint/4695/1/Antidiabetic_Effect_of_Oral_Borapetol_B_Compound%2C_Isolated_from_the_Plant_Tinospora_crispa%2C_by_Stimulating_Insulin_Release.pdf |
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| author | Lokman, Faradianna E. Harvest, F. Gu Wan Nazaimoon, Wan Mohamud M. M., Yusoff Keh, Leong Chia Claes-Göran, Östenson |
| author_facet | Lokman, Faradianna E. Harvest, F. Gu Wan Nazaimoon, Wan Mohamud M. M., Yusoff Keh, Leong Chia Claes-Göran, Östenson |
| author_sort | Lokman, Faradianna E. |
| collection | UMP |
| description | To evaluate the antidiabetic properties of borapetol B known as compound 1 (C1) isolated from Tinospora crispa in normoglycemic control Wistar (W) and spontaneously type 2 diabetic Goto-Kakizaki (GK) rats. Methods. The effect of C1 on blood glucose and plasma insulin was assessed by an oral glucose tolerance test. The effect of C1 on insulin secretion was assessed by batch incubation and perifusion experiments using isolated pancreatic islets. Results. An acute oral administration of C1 improved blood glucose levels in treated versus placebo groups with areas under glucose curves 0–120 min being versus mmol/L () and versus mmol/L () in W and GK rats, respectively. Plasma insulin levels were increased by 2-fold in treated W and GK rats versus placebo group at 30 min (). C1 dose-dependently increased insulin secretion from W and GK isolated islets at 3.3 mM and 16.7 mM glucose. The perifusions of isolated islets indicated that C1 did not cause leakage of insulin by damaging islet beta cells (). Conclusion. This study provides evidence that borapetol B (C1) has antidiabetic properties mainly due to its stimulation of insulin release. |
| first_indexed | 2024-03-06T11:43:10Z |
| format | Article |
| id | UMPir4695 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T11:43:10Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | UMPir46952018-07-27T01:42:27Z http://umpir.ump.edu.my/id/eprint/4695/ Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release Lokman, Faradianna E. Harvest, F. Gu Wan Nazaimoon, Wan Mohamud M. M., Yusoff Keh, Leong Chia Claes-Göran, Östenson QD Chemistry To evaluate the antidiabetic properties of borapetol B known as compound 1 (C1) isolated from Tinospora crispa in normoglycemic control Wistar (W) and spontaneously type 2 diabetic Goto-Kakizaki (GK) rats. Methods. The effect of C1 on blood glucose and plasma insulin was assessed by an oral glucose tolerance test. The effect of C1 on insulin secretion was assessed by batch incubation and perifusion experiments using isolated pancreatic islets. Results. An acute oral administration of C1 improved blood glucose levels in treated versus placebo groups with areas under glucose curves 0–120 min being versus mmol/L () and versus mmol/L () in W and GK rats, respectively. Plasma insulin levels were increased by 2-fold in treated W and GK rats versus placebo group at 30 min (). C1 dose-dependently increased insulin secretion from W and GK isolated islets at 3.3 mM and 16.7 mM glucose. The perifusions of isolated islets indicated that C1 did not cause leakage of insulin by damaging islet beta cells (). Conclusion. This study provides evidence that borapetol B (C1) has antidiabetic properties mainly due to its stimulation of insulin release. 2013-09-12 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/4695/1/Antidiabetic_Effect_of_Oral_Borapetol_B_Compound%2C_Isolated_from_the_Plant_Tinospora_crispa%2C_by_Stimulating_Insulin_Release.pdf Lokman, Faradianna E. and Harvest, F. Gu and Wan Nazaimoon, Wan Mohamud and M. M., Yusoff and Keh, Leong Chia and Claes-Göran, Östenson (2013) Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release. Evidence-Based Complementary and Alternative Medicine , 2013. (Published) http://www.hindawi.com/journals/ecam/2013/727602 Article ID 727602 |
| spellingShingle | QD Chemistry Lokman, Faradianna E. Harvest, F. Gu Wan Nazaimoon, Wan Mohamud M. M., Yusoff Keh, Leong Chia Claes-Göran, Östenson Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release |
| title | Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release |
| title_full | Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release |
| title_fullStr | Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release |
| title_full_unstemmed | Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release |
| title_short | Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release |
| title_sort | antidiabetic effect of oral borapetol b compound isolated from the plant tinospora crispa by stimulating insulin release |
| topic | QD Chemistry |
| url | http://umpir.ump.edu.my/id/eprint/4695/1/Antidiabetic_Effect_of_Oral_Borapetol_B_Compound%2C_Isolated_from_the_Plant_Tinospora_crispa%2C_by_Stimulating_Insulin_Release.pdf |
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