The Flavokawains: Uprising Medicinal Chalcones
lant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been don...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2013
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/5209/1/fist-2013-nadeem-artFlavokawainsUprising.pdf |
| _version_ | 1825821626981154816 |
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| author | Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Swee, Keong Yeap Mohd Puad, Abdullah Abdul Rahman, Omar Noorjahan Banu, Alitheen |
| author_facet | Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Swee, Keong Yeap Mohd Puad, Abdullah Abdul Rahman, Omar Noorjahan Banu, Alitheen |
| author_sort | Akhtar, Muhammad Nadeem |
| collection | UMP |
| description | lant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and C. Flavokawain B also exerts antinociceptive effects as well as anti-inflammation properties. This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported. |
| first_indexed | 2024-03-06T11:44:23Z |
| format | Article |
| id | UMPir5209 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T11:44:23Z |
| publishDate | 2013 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | UMPir52092018-04-19T00:58:12Z http://umpir.ump.edu.my/id/eprint/5209/ The Flavokawains: Uprising Medicinal Chalcones Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Swee, Keong Yeap Mohd Puad, Abdullah Abdul Rahman, Omar Noorjahan Banu, Alitheen QR Microbiology lant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and C. Flavokawain B also exerts antinociceptive effects as well as anti-inflammation properties. This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported. BioMed Central 2013 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/5209/1/fist-2013-nadeem-artFlavokawainsUprising.pdf Akhtar, Muhammad Nadeem and Nadiah, Abu and Wan, Yong Ho and Swee, Keong Yeap and Mohd Puad, Abdullah and Abdul Rahman, Omar and Noorjahan Banu, Alitheen (2013) The Flavokawains: Uprising Medicinal Chalcones. Cancer Cell International, 13 (201). pp. 1-7. ISSN 1475-2867 (print); 1475-2867 (online). (Published) http://dx.doi.org/10.1186/1475-2867-13-102 DOI: 10.1186/1475-2867-13-102 |
| spellingShingle | QR Microbiology Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Swee, Keong Yeap Mohd Puad, Abdullah Abdul Rahman, Omar Noorjahan Banu, Alitheen The Flavokawains: Uprising Medicinal Chalcones |
| title | The Flavokawains: Uprising Medicinal Chalcones |
| title_full | The Flavokawains: Uprising Medicinal Chalcones |
| title_fullStr | The Flavokawains: Uprising Medicinal Chalcones |
| title_full_unstemmed | The Flavokawains: Uprising Medicinal Chalcones |
| title_short | The Flavokawains: Uprising Medicinal Chalcones |
| title_sort | flavokawains uprising medicinal chalcones |
| topic | QR Microbiology |
| url | http://umpir.ump.edu.my/id/eprint/5209/1/fist-2013-nadeem-artFlavokawainsUprising.pdf |
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