Click Chemistry Approach: Regioselective One-pot Synthesis of Some New 8-Trifluoromethylquinoline Based 1,2,3-Triazoles as Potent Antimicrobial Agents
Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a–c, 6a–d and 7a–c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vit...
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| Format: | Article |
| Language: | English English |
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Elsevier
2014
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| Online Access: | http://umpir.ump.edu.my/id/eprint/5341/1/Click%20Chemistry%20Approach-%20Regioselective%20One-pot%20Synthesis%20of%20Some%20New%208-Trifluoromethylquinoline%20Based%201%2C2%2C3-Triazoles%20as%20Potent%20Antimicrobial%20Agents.pdf http://umpir.ump.edu.my/id/eprint/5341/7/Click%20Chemistry%20Approach-%20Regioselective%20One-pot%20Synthesis%20of%20Some%20New%208-Trifluoromethylquinoline%20Based%201%2C2%2C3-Triazoles%20as%20Potent%20Antimicrobial%20Agents.pdf |
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| author | Hegde, Gurumurthy Garudachari, B. Isloor, Arun M. Satyanarayana, M. N. Fun, Hoong-Kun |
| author_facet | Hegde, Gurumurthy Garudachari, B. Isloor, Arun M. Satyanarayana, M. N. Fun, Hoong-Kun |
| author_sort | Hegde, Gurumurthy |
| collection | UMP |
| description | Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a–c, 6a–d and 7a–c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6. |
| first_indexed | 2024-03-06T11:44:37Z |
| format | Article |
| id | UMPir5341 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-03-06T11:44:37Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | UMPir53412018-05-17T06:20:01Z http://umpir.ump.edu.my/id/eprint/5341/ Click Chemistry Approach: Regioselective One-pot Synthesis of Some New 8-Trifluoromethylquinoline Based 1,2,3-Triazoles as Potent Antimicrobial Agents Hegde, Gurumurthy Garudachari, B. Isloor, Arun M. Satyanarayana, M. N. Fun, Hoong-Kun TS Manufactures Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a–c, 6a–d and 7a–c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6. Elsevier 2014 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/5341/1/Click%20Chemistry%20Approach-%20Regioselective%20One-pot%20Synthesis%20of%20Some%20New%208-Trifluoromethylquinoline%20Based%201%2C2%2C3-Triazoles%20as%20Potent%20Antimicrobial%20Agents.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/5341/7/Click%20Chemistry%20Approach-%20Regioselective%20One-pot%20Synthesis%20of%20Some%20New%208-Trifluoromethylquinoline%20Based%201%2C2%2C3-Triazoles%20as%20Potent%20Antimicrobial%20Agents.pdf Hegde, Gurumurthy and Garudachari, B. and Isloor, Arun M. and Satyanarayana, M. N. and Fun, Hoong-Kun (2014) Click Chemistry Approach: Regioselective One-pot Synthesis of Some New 8-Trifluoromethylquinoline Based 1,2,3-Triazoles as Potent Antimicrobial Agents. European Journal of Medicinal Chemistry, 74. pp. 324-332. ISSN 0223-5234. (Published) http://dx.doi.org/10.1016/j.ejmech.2014.01.008 DOI: 10.1016/j.ejmech.2014.01.008 |
| spellingShingle | TS Manufactures Hegde, Gurumurthy Garudachari, B. Isloor, Arun M. Satyanarayana, M. N. Fun, Hoong-Kun Click Chemistry Approach: Regioselective One-pot Synthesis of Some New 8-Trifluoromethylquinoline Based 1,2,3-Triazoles as Potent Antimicrobial Agents |
| title | Click Chemistry Approach: Regioselective One-pot Synthesis of Some New 8-Trifluoromethylquinoline Based 1,2,3-Triazoles as Potent Antimicrobial Agents |
| title_full | Click Chemistry Approach: Regioselective One-pot Synthesis of Some New 8-Trifluoromethylquinoline Based 1,2,3-Triazoles as Potent Antimicrobial Agents |
| title_fullStr | Click Chemistry Approach: Regioselective One-pot Synthesis of Some New 8-Trifluoromethylquinoline Based 1,2,3-Triazoles as Potent Antimicrobial Agents |
| title_full_unstemmed | Click Chemistry Approach: Regioselective One-pot Synthesis of Some New 8-Trifluoromethylquinoline Based 1,2,3-Triazoles as Potent Antimicrobial Agents |
| title_short | Click Chemistry Approach: Regioselective One-pot Synthesis of Some New 8-Trifluoromethylquinoline Based 1,2,3-Triazoles as Potent Antimicrobial Agents |
| title_sort | click chemistry approach regioselective one pot synthesis of some new 8 trifluoromethylquinoline based 1 2 3 triazoles as potent antimicrobial agents |
| topic | TS Manufactures |
| url | http://umpir.ump.edu.my/id/eprint/5341/1/Click%20Chemistry%20Approach-%20Regioselective%20One-pot%20Synthesis%20of%20Some%20New%208-Trifluoromethylquinoline%20Based%201%2C2%2C3-Triazoles%20as%20Potent%20Antimicrobial%20Agents.pdf http://umpir.ump.edu.my/id/eprint/5341/7/Click%20Chemistry%20Approach-%20Regioselective%20One-pot%20Synthesis%20of%20Some%20New%208-Trifluoromethylquinoline%20Based%201%2C2%2C3-Triazoles%20as%20Potent%20Antimicrobial%20Agents.pdf |
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