Scaffolds from Chemically Modified Cellulose Nanofibers for Skin Tissue Engineering
The objective of this research is to develop a three-dimensional porous scaffold to support cell adhesion and proliferation and to guide cells moving into the repair area in the wound healing process by using electrospinning technique. A series of modified cellulose/PVA nanofibers scaffolds in diffe...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/5790/1/SCI-017.pdf |
| _version_ | 1825821688670978048 |
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| author | Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Chahal, Sugandha |
| author_facet | Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Chahal, Sugandha |
| author_sort | Farah Hanani, Zulkifli |
| collection | UMP |
| description | The objective of this research is to develop a three-dimensional porous scaffold to support cell adhesion and proliferation and to guide cells moving into the repair area in the wound healing process by using electrospinning technique. A series of modified cellulose/PVA nanofibers scaffolds in different concentrations were prepared and blended to evaluate the optimal tissue engineering scaffold. The cross-linking nanofibers scaffolds were characterized by scanning electron microscope(SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). SEM images revealed that with decreasing cellulose content the
average diameters of blend nanofibers were increased from 241±17.03 to 320±27.17 nm. Biocompatibility assay showed cells attached and spread actively on all modified cellulose nanofibers scaffolds with globular morphology after 7 days culturing which exhibit excellent biocompatibility and enhancement of cell penetration and growth within nanofibers mats. Results indicate that the modified cellulose have potential application in skin tissue engineering. |
| first_indexed | 2024-03-06T11:45:19Z |
| format | Conference or Workshop Item |
| id | UMPir5790 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T11:45:19Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | UMPir57902018-07-26T06:56:47Z http://umpir.ump.edu.my/id/eprint/5790/ Scaffolds from Chemically Modified Cellulose Nanofibers for Skin Tissue Engineering Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Chahal, Sugandha QD Chemistry The objective of this research is to develop a three-dimensional porous scaffold to support cell adhesion and proliferation and to guide cells moving into the repair area in the wound healing process by using electrospinning technique. A series of modified cellulose/PVA nanofibers scaffolds in different concentrations were prepared and blended to evaluate the optimal tissue engineering scaffold. The cross-linking nanofibers scaffolds were characterized by scanning electron microscope(SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). SEM images revealed that with decreasing cellulose content the average diameters of blend nanofibers were increased from 241±17.03 to 320±27.17 nm. Biocompatibility assay showed cells attached and spread actively on all modified cellulose nanofibers scaffolds with globular morphology after 7 days culturing which exhibit excellent biocompatibility and enhancement of cell penetration and growth within nanofibers mats. Results indicate that the modified cellulose have potential application in skin tissue engineering. 2013 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/5790/1/SCI-017.pdf Farah Hanani, Zulkifli and Jahir Hussain, Fathima Shahitha and M. M., Yusoff and Chahal, Sugandha (2013) Scaffolds from Chemically Modified Cellulose Nanofibers for Skin Tissue Engineering. In: Malaysian Technical Universities Conference on Engineering & Technology (MUCET 2013) , 3-4 December 2013 , Kuantan, Pahang. p. 1.. (Published) |
| spellingShingle | QD Chemistry Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Chahal, Sugandha Scaffolds from Chemically Modified Cellulose Nanofibers for Skin Tissue Engineering |
| title | Scaffolds from Chemically Modified Cellulose Nanofibers for Skin Tissue Engineering |
| title_full | Scaffolds from Chemically Modified Cellulose Nanofibers for Skin Tissue Engineering |
| title_fullStr | Scaffolds from Chemically Modified Cellulose Nanofibers for Skin Tissue Engineering |
| title_full_unstemmed | Scaffolds from Chemically Modified Cellulose Nanofibers for Skin Tissue Engineering |
| title_short | Scaffolds from Chemically Modified Cellulose Nanofibers for Skin Tissue Engineering |
| title_sort | scaffolds from chemically modified cellulose nanofibers for skin tissue engineering |
| topic | QD Chemistry |
| url | http://umpir.ump.edu.my/id/eprint/5790/1/SCI-017.pdf |
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