Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering
In this study, a novel fibrous membrane of hydroxyethyl cellulose (HEC)/poly(vinyl alcohol) blend was successfully fabricated by electrospinning technique and characterized. The concentration of HEC (5%) with PVA (15%) was optimized, blended in different ratios (30–50%) and electrospun to get smooth...
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| Format: | Article |
| Language: | English English |
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Elsevier Ltd
2014
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| Online Access: | http://umpir.ump.edu.my/id/eprint/6597/1/Nanostructured%20Materials%20from%20Hydroxyethyl%20Cellulose%20for%20Skin%20Tissue%20Engineering.pdf http://umpir.ump.edu.my/id/eprint/6597/7/Nanostructured%20Materials%20From%20Hydroxyethyl%20Cellulose%20For%20Skin%20Tissue%20Engineering.pdf |
| _version_ | 1796990127776464896 |
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| author | Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad |
| author_facet | Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad |
| author_sort | Farah Hanani, Zulkifli |
| collection | UMP |
| description | In this study, a novel fibrous membrane of hydroxyethyl cellulose (HEC)/poly(vinyl alcohol) blend was successfully fabricated by electrospinning technique and characterized. The concentration of HEC (5%) with PVA (15%) was optimized, blended in different ratios (30–50%) and electrospun to get smooth nanofibers. Nanofibrous membranes were made water insoluble by chemically cross-linking by glutaraldehyde and used as scaffolds for the skin tissue engineering. The microstructure, morphology, mechanical and thermal properties of the blended HEC/PVA nanofibrous scaffolds were characterized by scanning electron microscope, Fourier transform infrared spectroscopy, differential scanning colorimetry, universal testing machine and thermogravimetric analysis. Cytotoxicity studies on these nanofibrous scaffolds were carried out using human melanoma cells by the MTT assays. The cells were able to attach and spread in the nanofibrous scaffolds as shown by the SEM images. These preliminary results show that these nanofibrous scaffolds that supports cell adhesion and proliferation is promising for skin tissue engineering. |
| first_indexed | 2024-03-06T11:47:02Z |
| format | Article |
| id | UMPir6597 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-03-06T11:47:02Z |
| publishDate | 2014 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | UMPir65972018-07-26T06:55:01Z http://umpir.ump.edu.my/id/eprint/6597/ Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad Q Science (General) QD Chemistry In this study, a novel fibrous membrane of hydroxyethyl cellulose (HEC)/poly(vinyl alcohol) blend was successfully fabricated by electrospinning technique and characterized. The concentration of HEC (5%) with PVA (15%) was optimized, blended in different ratios (30–50%) and electrospun to get smooth nanofibers. Nanofibrous membranes were made water insoluble by chemically cross-linking by glutaraldehyde and used as scaffolds for the skin tissue engineering. The microstructure, morphology, mechanical and thermal properties of the blended HEC/PVA nanofibrous scaffolds were characterized by scanning electron microscope, Fourier transform infrared spectroscopy, differential scanning colorimetry, universal testing machine and thermogravimetric analysis. Cytotoxicity studies on these nanofibrous scaffolds were carried out using human melanoma cells by the MTT assays. The cells were able to attach and spread in the nanofibrous scaffolds as shown by the SEM images. These preliminary results show that these nanofibrous scaffolds that supports cell adhesion and proliferation is promising for skin tissue engineering. Elsevier Ltd 2014 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6597/1/Nanostructured%20Materials%20from%20Hydroxyethyl%20Cellulose%20for%20Skin%20Tissue%20Engineering.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/6597/7/Nanostructured%20Materials%20From%20Hydroxyethyl%20Cellulose%20For%20Skin%20Tissue%20Engineering.pdf Farah Hanani, Zulkifli and Jahir Hussain, Fathima Shahitha and M. M., Yusoff and Mohammad Syaiful Bahari, Abdull Rasad (2014) Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering. Carbohydrate Polymers, 114. pp. 238-245. ISSN 0144-8617. (Published) http://dx.doi.org/10.1016/j.carbpol.2014.08.019 DOI: 10.1016/j.carbpol.2014.08.019 |
| spellingShingle | Q Science (General) QD Chemistry Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering |
| title | Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering |
| title_full | Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering |
| title_fullStr | Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering |
| title_full_unstemmed | Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering |
| title_short | Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering |
| title_sort | nanostructured materials from hydroxyethyl cellulose for skin tissue engineering |
| topic | Q Science (General) QD Chemistry |
| url | http://umpir.ump.edu.my/id/eprint/6597/1/Nanostructured%20Materials%20from%20Hydroxyethyl%20Cellulose%20for%20Skin%20Tissue%20Engineering.pdf http://umpir.ump.edu.my/id/eprint/6597/7/Nanostructured%20Materials%20From%20Hydroxyethyl%20Cellulose%20For%20Skin%20Tissue%20Engineering.pdf |
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