Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System
Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol so...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Trans Tech Publications, Switzerland
2015
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/6653/1/solubility_of_carbamazepine-succinic_co-crystal_in_ethanolic_solvent_system.pdf |
| _version_ | 1825821812496269312 |
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| author | Noor Ashila, Ramle Syarifah, Abd Rahim El-Hadad, Omar Nornizar, Anuar |
| author_facet | Noor Ashila, Ramle Syarifah, Abd Rahim El-Hadad, Omar Nornizar, Anuar |
| author_sort | Noor Ashila, Ramle |
| collection | UMP |
| description | Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol solvent system were conducted at 6 different temperatures (25, 30, 35, 40, 45 and 50°c) while for succinic acid solution system were conducted at 5 different concentration ratio. Both of the system are equilibrated for 72 hours. Result from the experiment has shown that the solubility of co-crystal is depending on temperature. As the temperature increase, the solubility of co-crystal also increased, this situation meets the Second Law of Thermodynamic which heat facilitates the dissolution process by providing more energy to the system. |
| first_indexed | 2024-03-06T11:47:11Z |
| format | Article |
| id | UMPir6653 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T11:47:11Z |
| publishDate | 2015 |
| publisher | Trans Tech Publications, Switzerland |
| record_format | dspace |
| spelling | UMPir66532017-09-29T07:57:10Z http://umpir.ump.edu.my/id/eprint/6653/ Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System Noor Ashila, Ramle Syarifah, Abd Rahim El-Hadad, Omar Nornizar, Anuar TP Chemical technology Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol solvent system were conducted at 6 different temperatures (25, 30, 35, 40, 45 and 50°c) while for succinic acid solution system were conducted at 5 different concentration ratio. Both of the system are equilibrated for 72 hours. Result from the experiment has shown that the solubility of co-crystal is depending on temperature. As the temperature increase, the solubility of co-crystal also increased, this situation meets the Second Law of Thermodynamic which heat facilitates the dissolution process by providing more energy to the system. Trans Tech Publications, Switzerland 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6653/1/solubility_of_carbamazepine-succinic_co-crystal_in_ethanolic_solvent_system.pdf Noor Ashila, Ramle and Syarifah, Abd Rahim and El-Hadad, Omar and Nornizar, Anuar (2015) Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System. Advanced Materials Research, 1113. pp. 434-439. ISSN 1022-6680 (print), 1662-8985 (online). (Published) https://www.scientific.net/AMR.1113.434 doi: 10.4028/www.scientific.net/AMR.1113.434 |
| spellingShingle | TP Chemical technology Noor Ashila, Ramle Syarifah, Abd Rahim El-Hadad, Omar Nornizar, Anuar Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System |
| title | Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System |
| title_full | Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System |
| title_fullStr | Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System |
| title_full_unstemmed | Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System |
| title_short | Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System |
| title_sort | solubility of carbamazepine succinic co crystal in ethanolic solvent system |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/6653/1/solubility_of_carbamazepine-succinic_co-crystal_in_ethanolic_solvent_system.pdf |
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