Comparison product optimization performance of fed-batch fermentation processes for penicillin G production
This paper discusses the development of optimization strategies for a fed-batch penicillin fermentation process. To facilitate the study, a mathematical model of the system was developed. The model was simulated in MATLAB environment and good result was obtained. To provide on-line estimates of the...
| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English |
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2006
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| Online Access: | http://umpir.ump.edu.my/id/eprint/7232/1/fkksa-2006-NoorAsma-Comparison_Product_Optimization.pdf |
| _version_ | 1825821909451800576 |
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| author | Noor Asma Fazli, Abdul Samad Arshad, Ahmad |
| author_facet | Noor Asma Fazli, Abdul Samad Arshad, Ahmad |
| author_sort | Noor Asma Fazli, Abdul Samad |
| collection | UMP |
| description | This paper discusses the development of optimization strategies for a fed-batch penicillin fermentation process. To facilitate the study, a mathematical model of the system was developed. The model was simulated in MATLAB environment and good result was obtained. To provide on-line estimates of the difficult to measure penicillin concentration, Partial Least Squares model was employed. These estimates were then used in the control loop and successful control of the product concentration was established. This provided the opportunity for optimizing the fermentation operation, in particular to further increase the achievable product concentration while satisfying all process constraints. In order to carry out this procedure, two optimization algorithms were selected. First, dynamic optimization using direct shooting method and second is implementation single step ahead Dynamic Matrix Control (DMC). Comparison of these two different approaches was discussed and it was found this single step ahead DMC algorithm shown a best result with an optimization procedure. |
| first_indexed | 2024-03-06T11:48:39Z |
| format | Conference or Workshop Item |
| id | UMPir7232 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2025-02-19T02:37:06Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | UMPir72322025-02-04T04:01:32Z http://umpir.ump.edu.my/id/eprint/7232/ Comparison product optimization performance of fed-batch fermentation processes for penicillin G production Noor Asma Fazli, Abdul Samad Arshad, Ahmad QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology This paper discusses the development of optimization strategies for a fed-batch penicillin fermentation process. To facilitate the study, a mathematical model of the system was developed. The model was simulated in MATLAB environment and good result was obtained. To provide on-line estimates of the difficult to measure penicillin concentration, Partial Least Squares model was employed. These estimates were then used in the control loop and successful control of the product concentration was established. This provided the opportunity for optimizing the fermentation operation, in particular to further increase the achievable product concentration while satisfying all process constraints. In order to carry out this procedure, two optimization algorithms were selected. First, dynamic optimization using direct shooting method and second is implementation single step ahead Dynamic Matrix Control (DMC). Comparison of these two different approaches was discussed and it was found this single step ahead DMC algorithm shown a best result with an optimization procedure. 2006 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/7232/1/fkksa-2006-NoorAsma-Comparison_Product_Optimization.pdf Noor Asma Fazli, Abdul Samad and Arshad, Ahmad (2006) Comparison product optimization performance of fed-batch fermentation processes for penicillin G production. In: Proceedings of the 1st International Conference on Natural Resources Engineering & Technology 2006. Proceedings of the 1st International Conference on Natural Resources Engineering & Technology 2006 , 24-25 July 2014 , Putrajaya. pp. 562-575.. (Published) |
| spellingShingle | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Noor Asma Fazli, Abdul Samad Arshad, Ahmad Comparison product optimization performance of fed-batch fermentation processes for penicillin G production |
| title | Comparison product optimization performance of fed-batch fermentation processes for penicillin G production |
| title_full | Comparison product optimization performance of fed-batch fermentation processes for penicillin G production |
| title_fullStr | Comparison product optimization performance of fed-batch fermentation processes for penicillin G production |
| title_full_unstemmed | Comparison product optimization performance of fed-batch fermentation processes for penicillin G production |
| title_short | Comparison product optimization performance of fed-batch fermentation processes for penicillin G production |
| title_sort | comparison product optimization performance of fed batch fermentation processes for penicillin g production |
| topic | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/7232/1/fkksa-2006-NoorAsma-Comparison_Product_Optimization.pdf |
| work_keys_str_mv | AT noorasmafazliabdulsamad comparisonproductoptimizationperformanceoffedbatchfermentationprocessesforpenicillingproduction AT arshadahmad comparisonproductoptimizationperformanceoffedbatchfermentationprocessesforpenicillingproduction |