Monovalent Maleimide Functionalization of Gold Nanoparticles Via Copper-Free Click Chemistry

A single maleimide was installed onto the self-assembled monolayer of gold nanoparticles by copper-free click chemistry. Simple covalent biofunctionalisation is demonstrated by coupling fibroblast growth factor 2 and an oligosaccharide in a 1 : 1 stoichiometry by thiol-Michael addition.

Bibliographic Details
Main Authors: D. J., Nieves, N. S., Azmi, R., Xu, R., Levy, E. A., Yates, D. G., Fernig
Format: Article
Language:English
Published: 2014
Subjects:
Online Access:http://umpir.ump.edu.my/id/eprint/7877/1/Monovalent_maleimide_functionalization_of_gold_nanoparticles_via_copper-free_click_chemistry.pdf
Description
Summary:A single maleimide was installed onto the self-assembled monolayer of gold nanoparticles by copper-free click chemistry. Simple covalent biofunctionalisation is demonstrated by coupling fibroblast growth factor 2 and an oligosaccharide in a 1 : 1 stoichiometry by thiol-Michael addition.