Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives
A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide 4(ael) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)-3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6(ael) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine....
| _version_ | 1825822049978810368 |
|---|---|
| author | Hegde, Gurumurthy Boodappa, Chandrakantha Isloor, Arun M. Shetty, Prakash Sook, Fun Pang |
| author_facet | Hegde, Gurumurthy Boodappa, Chandrakantha Isloor, Arun M. Shetty, Prakash Sook, Fun Pang |
| author_sort | Hegde, Gurumurthy |
| collection | UMP |
| description | A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide 4(ael) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)-3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6(ael) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a,4c and 6e,6g displayed appreciable activity at the concentration 0.5 - 1.0 mg/mL. |
| first_indexed | 2024-03-06T11:50:46Z |
| format | Article |
| id | UMPir8073 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-03-06T11:50:46Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | UMPir80732018-05-17T06:30:23Z http://umpir.ump.edu.my/id/eprint/8073/ Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives Hegde, Gurumurthy Boodappa, Chandrakantha Isloor, Arun M. Shetty, Prakash Sook, Fun Pang QD Chemistry QC Physics A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide 4(ael) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)-3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6(ael) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a,4c and 6e,6g displayed appreciable activity at the concentration 0.5 - 1.0 mg/mL. Elsevier 2014 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/8073/1/Synthesis%20and%20Biological%20Evaluation%20of%20Novel%20Substituted%201%2C3%2C4-Thiadiazole%20and%202%2C6-Di%20Aryl%20Substituted%20Imidazo%20%5B2%2C1-B%5D%20%5B1%2C3%2C4%5D%20Thiadiazole%20Derivatives.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/8073/7/Synthesis%20and%20Biological%20Evaluation%20of%20Novel%20Substituted%201%2C3%2C4-Thiadiazole%20and%202%2C6-Di%20Aryl%20Substituted%20Imidazo%20%5B2%2C1-B%5D%20%5B1%2C3%2C4%5D%20Thiadiazole%20Derivatives.pdf Hegde, Gurumurthy and Boodappa, Chandrakantha and Isloor, Arun M. and Shetty, Prakash and Sook, Fun Pang (2014) Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives. European Journal of Medicinal Chemistry, 71. pp. 316-323. ISSN 0223-5234 (prin); 1768-3254 (online). (Published) http://dx.doi.org/10.1016/j.ejmech.2013.10.056 DOI: 10.1016/j.ejmech.2013.10.056 |
| spellingShingle | QD Chemistry QC Physics Hegde, Gurumurthy Boodappa, Chandrakantha Isloor, Arun M. Shetty, Prakash Sook, Fun Pang Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives |
| title | Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-
b] [1,3,4]thiadiazole Derivatives |
| title_full | Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-
b] [1,3,4]thiadiazole Derivatives |
| title_fullStr | Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-
b] [1,3,4]thiadiazole Derivatives |
| title_full_unstemmed | Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-
b] [1,3,4]thiadiazole Derivatives |
| title_short | Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-
b] [1,3,4]thiadiazole Derivatives |
| title_sort | synthesis and biological evaluation of novel substituted 1 3 4 thiadiazole and 2 6 di aryl substituted imidazo 2 1 b 1 3 4 thiadiazole derivatives |
| topic | QD Chemistry QC Physics |
| url | http://umpir.ump.edu.my/id/eprint/8073/1/Synthesis%20and%20Biological%20Evaluation%20of%20Novel%20Substituted%201%2C3%2C4-Thiadiazole%20and%202%2C6-Di%20Aryl%20Substituted%20Imidazo%20%5B2%2C1-B%5D%20%5B1%2C3%2C4%5D%20Thiadiazole%20Derivatives.pdf http://umpir.ump.edu.my/id/eprint/8073/7/Synthesis%20and%20Biological%20Evaluation%20of%20Novel%20Substituted%201%2C3%2C4-Thiadiazole%20and%202%2C6-Di%20Aryl%20Substituted%20Imidazo%20%5B2%2C1-B%5D%20%5B1%2C3%2C4%5D%20Thiadiazole%20Derivatives.pdf |
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