High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction
Abstract Aims The impacts of high density lipoprotein cholesterol (HDL‐C) as an anti‐inflammatory and C reactive protein (CRP) as inflammatory properties on the pathogenesis of heart failure were reported. At present, the clinical significance of the HDL‐C/CRP ratio in heart failure with preserved e...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-08-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13350 |
| _version_ | 1819138870665543680 |
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| author | Masamichi Yano Masami Nishino Kohei Ukita Akito Kawamura Hitoshi Nakamura Yutaka Matsuhiro Koji Yasumoto Masaki Tsuda Naotaka Okamoto Akihiro Tanaka Yasuharu Matsunaga‐Lee Yasuyuki Egami Ryu Shutta Jun Tanouchi Takahisa Yamada Yoshio Yasumura Shunsuke Tamaki Takaharu Hayashi Akito Nakagawa Yusuke Nakagawa Shinichiro Suna Daisaku Nakatani Shungo Hikoso Yasushi Sakata Osaka CardioVascular Conference (OCVC)‐Heart Failure Investigators |
| author_facet | Masamichi Yano Masami Nishino Kohei Ukita Akito Kawamura Hitoshi Nakamura Yutaka Matsuhiro Koji Yasumoto Masaki Tsuda Naotaka Okamoto Akihiro Tanaka Yasuharu Matsunaga‐Lee Yasuyuki Egami Ryu Shutta Jun Tanouchi Takahisa Yamada Yoshio Yasumura Shunsuke Tamaki Takaharu Hayashi Akito Nakagawa Yusuke Nakagawa Shinichiro Suna Daisaku Nakatani Shungo Hikoso Yasushi Sakata Osaka CardioVascular Conference (OCVC)‐Heart Failure Investigators |
| author_sort | Masamichi Yano |
| collection | DOAJ |
| description | Abstract Aims The impacts of high density lipoprotein cholesterol (HDL‐C) as an anti‐inflammatory and C reactive protein (CRP) as inflammatory properties on the pathogenesis of heart failure were reported. At present, the clinical significance of the HDL‐C/CRP ratio in heart failure with preserved ejection fraction (HFpEF) patients remains unknown. Methods and results We examined the data on 796 consecutive HFpEF (left ventricular ejection fraction ≥50%) patients hospitalized due to acute decompensated heart failure from the PURSUIT‐HFpEF registry, a prospective, multicentre observational study. We calculated the HDL/CRP ratios and evaluated the relationship between the values and clinical outcomes, including degree of cardiac function. The mean follow‐up duration was 420 ± 346 days. All‐cause death occurred in 118 patients, of which 51 were cardiac deaths. HDL/CRP ≤ 4.05 was independently and significantly associated with all‐cause death (odds ratio = 1.84, 95% CI: 1.06–3.20, P = 0.023), and HDL/CRP ≤ 3.14 was associated with cardiac death by multivariate Cox proportional hazard analysis (odds ratio = 2.86, 95% CI: 1.36–6.01, P = 0.003). HDL‐C/CRP ratio significantly correlated with the product of the left atrial volume and left ventricular mass index as well as the tricuspid annular plane systolic excursion by multiple regression analysis (standardized beta‐coefficient = −0.085, P = 0.034 and standardized beta‐coefficient = 0.081, P = 0.044, respectively). Conclusions HDL‐C/CRP ratio was a useful marker for predicting all‐cause death and cardiac death and correlated with left ventricular diastolic function and right ventricular systolic function in HFpEF patients. |
| first_indexed | 2024-12-22T11:13:38Z |
| format | Article |
| id | doaj.art-000113fefae746f285bb0244e5177907 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-12-22T11:13:38Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-000113fefae746f285bb0244e51779072022-12-21T18:28:04ZengWileyESC Heart Failure2055-58222021-08-01842791280110.1002/ehf2.13350High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fractionMasamichi Yano0Masami Nishino1Kohei Ukita2Akito Kawamura3Hitoshi Nakamura4Yutaka Matsuhiro5Koji Yasumoto6Masaki Tsuda7Naotaka Okamoto8Akihiro Tanaka9Yasuharu Matsunaga‐Lee10Yasuyuki Egami11Ryu Shutta12Jun Tanouchi13Takahisa Yamada14Yoshio Yasumura15Shunsuke Tamaki16Takaharu Hayashi17Akito Nakagawa18Yusuke Nakagawa19Shinichiro Suna20Daisaku Nakatani21Shungo Hikoso22Yasushi Sakata23Osaka CardioVascular Conference (OCVC)‐Heart Failure InvestigatorsDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka Rosai Hospital 3‐1179 Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 JapanDivision of Cardiology Osaka General Medical Center Osaka JapanDivision of Cardiology Amagasaki Chuo Hospital Amagasaki JapanDivision of Cardiology Osaka General Medical Center Osaka JapanCardiovascular Division Osaka Police Hospital Osaka JapanDivision of Cardiology Amagasaki Chuo Hospital Amagasaki JapanDivision of Cardiology Kawanishi City Hospital Kawanishi JapanDepartment of Cardiovascular Medicine Osaka University Graduate School of Medicine Suita JapanDepartment of Cardiovascular Medicine Osaka University Graduate School of Medicine Suita JapanDepartment of Cardiovascular Medicine Osaka University Graduate School of Medicine Suita JapanDepartment of Cardiovascular Medicine Osaka University Graduate School of Medicine Suita JapanAbstract Aims The impacts of high density lipoprotein cholesterol (HDL‐C) as an anti‐inflammatory and C reactive protein (CRP) as inflammatory properties on the pathogenesis of heart failure were reported. At present, the clinical significance of the HDL‐C/CRP ratio in heart failure with preserved ejection fraction (HFpEF) patients remains unknown. Methods and results We examined the data on 796 consecutive HFpEF (left ventricular ejection fraction ≥50%) patients hospitalized due to acute decompensated heart failure from the PURSUIT‐HFpEF registry, a prospective, multicentre observational study. We calculated the HDL/CRP ratios and evaluated the relationship between the values and clinical outcomes, including degree of cardiac function. The mean follow‐up duration was 420 ± 346 days. All‐cause death occurred in 118 patients, of which 51 were cardiac deaths. HDL/CRP ≤ 4.05 was independently and significantly associated with all‐cause death (odds ratio = 1.84, 95% CI: 1.06–3.20, P = 0.023), and HDL/CRP ≤ 3.14 was associated with cardiac death by multivariate Cox proportional hazard analysis (odds ratio = 2.86, 95% CI: 1.36–6.01, P = 0.003). HDL‐C/CRP ratio significantly correlated with the product of the left atrial volume and left ventricular mass index as well as the tricuspid annular plane systolic excursion by multiple regression analysis (standardized beta‐coefficient = −0.085, P = 0.034 and standardized beta‐coefficient = 0.081, P = 0.044, respectively). Conclusions HDL‐C/CRP ratio was a useful marker for predicting all‐cause death and cardiac death and correlated with left ventricular diastolic function and right ventricular systolic function in HFpEF patients.https://doi.org/10.1002/ehf2.13350Heart failure with preserved ejection fractionInflammationHigh density lipoprotein cholesterol/C reactive protein ratioLeft ventricular diastolic functionRight ventricular systolic function |
| spellingShingle | Masamichi Yano Masami Nishino Kohei Ukita Akito Kawamura Hitoshi Nakamura Yutaka Matsuhiro Koji Yasumoto Masaki Tsuda Naotaka Okamoto Akihiro Tanaka Yasuharu Matsunaga‐Lee Yasuyuki Egami Ryu Shutta Jun Tanouchi Takahisa Yamada Yoshio Yasumura Shunsuke Tamaki Takaharu Hayashi Akito Nakagawa Yusuke Nakagawa Shinichiro Suna Daisaku Nakatani Shungo Hikoso Yasushi Sakata Osaka CardioVascular Conference (OCVC)‐Heart Failure Investigators High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction ESC Heart Failure Heart failure with preserved ejection fraction Inflammation High density lipoprotein cholesterol/C reactive protein ratio Left ventricular diastolic function Right ventricular systolic function |
| title | High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction |
| title_full | High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction |
| title_fullStr | High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction |
| title_full_unstemmed | High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction |
| title_short | High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction |
| title_sort | high density lipoprotein cholesterol c reactive protein ratio in heart failure with preserved ejection fraction |
| topic | Heart failure with preserved ejection fraction Inflammation High density lipoprotein cholesterol/C reactive protein ratio Left ventricular diastolic function Right ventricular systolic function |
| url | https://doi.org/10.1002/ehf2.13350 |
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