Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging
Background: Apolipoprotein E (APOE) ɛ4 is associated with poor outcome following moderate to severe traumatic brain injury (TBI). There is a lack of studies investigating the influence of APOE ɛ4 on intracranial pathology following mild traumatic brain injury (MTBI). This study explores the associat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/3/418 |
| _version_ | 1797408411959164928 |
|---|---|
| author | Torgeir Hellstrøm Nada Andelic Ann-Marie G. de Lange Eirik Helseth Kristin Eiklid Lars T. Westlye |
| author_facet | Torgeir Hellstrøm Nada Andelic Ann-Marie G. de Lange Eirik Helseth Kristin Eiklid Lars T. Westlye |
| author_sort | Torgeir Hellstrøm |
| collection | DOAJ |
| description | Background: Apolipoprotein E (APOE) ɛ4 is associated with poor outcome following moderate to severe traumatic brain injury (TBI). There is a lack of studies investigating the influence of APOE ɛ4 on intracranial pathology following mild traumatic brain injury (MTBI). This study explores the association between APOE ɛ4 and MRI measures of brain age prediction, brain morphometry, and diffusion tensor imaging (DTI). Methods: Patients aged 16 to 65 with acute MTBI admitted to the trauma center were included. Multimodal MRI was performed 12 months after injury and associated with APOE ɛ4 status. Corrections for multiple comparisons were done using false discovery rate (FDR). Results: Of included patients, 123 patients had available APOE, volumetric, and DTI data of sufficient quality. There were no differences between APOE ɛ4 carriers (39%) and non-carriers in demographic and clinical data. Age prediction revealed high accuracy both for the DTI-based and the brain morphometry based model. Group comparisons revealed no significant differences in brain-age gap between ɛ4 carriers and non-carriers, and no significant differences in conventional measures of brain morphometry and volumes. Compared to non-carriers, APOE ɛ4 carriers showed lower fractional anisotropy (FA) in the hippocampal part of the cingulum bundle, which did not remain significant after FDR adjustment. Conclusion: APOE ɛ4 carriers might be vulnerable to reduced neuronal integrity in the cingulum. Larger cohort studies are warranted to replicate this finding. |
| first_indexed | 2024-03-09T03:58:06Z |
| format | Article |
| id | doaj.art-00024733536f4bf1bbfea8daf3462eee |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T03:58:06Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-00024733536f4bf1bbfea8daf3462eee2023-12-03T14:16:22ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110341810.3390/jcm10030418Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor ImagingTorgeir Hellstrøm0Nada Andelic1Ann-Marie G. de Lange2Eirik Helseth3Kristin Eiklid4Lars T. Westlye5Department of Physical Medicine and Rehabilitation, Oslo University Hospital, 0424 Oslo, NorwayDepartment of Physical Medicine and Rehabilitation, Oslo University Hospital, 0424 Oslo, NorwayDepartment of Psychology, Faculty of Social Sciences, University of Oslo, 0317 Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, NorwayDepartment of Medical Genetic, Oslo University Hospital, 0424 Oslo, NorwayDepartment of Psychology, Faculty of Social Sciences, University of Oslo, 0317 Oslo, NorwayBackground: Apolipoprotein E (APOE) ɛ4 is associated with poor outcome following moderate to severe traumatic brain injury (TBI). There is a lack of studies investigating the influence of APOE ɛ4 on intracranial pathology following mild traumatic brain injury (MTBI). This study explores the association between APOE ɛ4 and MRI measures of brain age prediction, brain morphometry, and diffusion tensor imaging (DTI). Methods: Patients aged 16 to 65 with acute MTBI admitted to the trauma center were included. Multimodal MRI was performed 12 months after injury and associated with APOE ɛ4 status. Corrections for multiple comparisons were done using false discovery rate (FDR). Results: Of included patients, 123 patients had available APOE, volumetric, and DTI data of sufficient quality. There were no differences between APOE ɛ4 carriers (39%) and non-carriers in demographic and clinical data. Age prediction revealed high accuracy both for the DTI-based and the brain morphometry based model. Group comparisons revealed no significant differences in brain-age gap between ɛ4 carriers and non-carriers, and no significant differences in conventional measures of brain morphometry and volumes. Compared to non-carriers, APOE ɛ4 carriers showed lower fractional anisotropy (FA) in the hippocampal part of the cingulum bundle, which did not remain significant after FDR adjustment. Conclusion: APOE ɛ4 carriers might be vulnerable to reduced neuronal integrity in the cingulum. Larger cohort studies are warranted to replicate this finding.https://www.mdpi.com/2077-0383/10/3/418mild traumatic brain injuryAPOEbrain-age gapMRI |
| spellingShingle | Torgeir Hellstrøm Nada Andelic Ann-Marie G. de Lange Eirik Helseth Kristin Eiklid Lars T. Westlye Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging Journal of Clinical Medicine mild traumatic brain injury APOE brain-age gap MRI |
| title | Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging |
| title_full | Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging |
| title_fullStr | Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging |
| title_full_unstemmed | Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging |
| title_short | Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging |
| title_sort | apolipoprotein e4 status and brain structure 12 months after mild traumatic injury brain age prediction using brain morphometry and diffusion tensor imaging |
| topic | mild traumatic brain injury APOE brain-age gap MRI |
| url | https://www.mdpi.com/2077-0383/10/3/418 |
| work_keys_str_mv | AT torgeirhellstrøm apolipoproteinɛ4statusandbrainstructure12monthsaftermildtraumaticinjurybrainagepredictionusingbrainmorphometryanddiffusiontensorimaging AT nadaandelic apolipoproteinɛ4statusandbrainstructure12monthsaftermildtraumaticinjurybrainagepredictionusingbrainmorphometryanddiffusiontensorimaging AT annmariegdelange apolipoproteinɛ4statusandbrainstructure12monthsaftermildtraumaticinjurybrainagepredictionusingbrainmorphometryanddiffusiontensorimaging AT eirikhelseth apolipoproteinɛ4statusandbrainstructure12monthsaftermildtraumaticinjurybrainagepredictionusingbrainmorphometryanddiffusiontensorimaging AT kristineiklid apolipoproteinɛ4statusandbrainstructure12monthsaftermildtraumaticinjurybrainagepredictionusingbrainmorphometryanddiffusiontensorimaging AT larstwestlye apolipoproteinɛ4statusandbrainstructure12monthsaftermildtraumaticinjurybrainagepredictionusingbrainmorphometryanddiffusiontensorimaging |