Challenging hepatitis C-infected liver transplant patients
Madeleine Oliver,1 Christopher Chiodo Ortiz,2 Jorge Ortiz31University of Toledo College of Medicine, Toledo, OH, 2Bucknell University, Lewisburg, PA, 3Department of Transplant Surgery, University of Toledo Medical Center, Toledo, OH, USA Abstract: Caring for liver transplant patients suffering from...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2016-01-01
|
| Series: | Hepatic Medicine: Evidence and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/challenging-hepatitis-c-infected-liver-transplant-patients-peer-reviewed-article-HMER |
| _version_ | 1818683667566821376 |
|---|---|
| author | Oliver M Chiodo Ortiz C Ortiz J |
| author_facet | Oliver M Chiodo Ortiz C Ortiz J |
| author_sort | Oliver M |
| collection | DOAJ |
| description | Madeleine Oliver,1 Christopher Chiodo Ortiz,2 Jorge Ortiz31University of Toledo College of Medicine, Toledo, OH, 2Bucknell University, Lewisburg, PA, 3Department of Transplant Surgery, University of Toledo Medical Center, Toledo, OH, USA Abstract: Caring for liver transplant patients suffering from chronic hepatitis C virus (HCV) infection is a challenging task for transplant surgeons and primary physicians alike. HCV is the leading cause of liver transplantation in the USA and comes with a myriad of complications that increase morbidity and mortality. This review focuses on patient follow-up, spanning from before the liver transplant occurs to the patient's long-term health. Pretransplant, both donor and recipient variables, must be carefully chosen to ensure optimal surgical success. Risk factors must be identified and HCV viral load must be reduced to a minimum. In addition to standard transplant complications, HCV patients suffer from additional problems, such as fibrosing cholestatic hepatitis and widespread viremia. Physicians must focus on the balance of immunosuppressive and antiviral medications, while considering possible side effects from these potent drugs. Over the years following surgery, physicians must identify any signs of failing liver health, as HCV-positive patients have an increased risk for cirrhosis and certain life-threatening malignancies. Keywords: liver transplant, hepatitis C virus, postoperative, cirrhosis, donor and recipient variables, viremia |
| first_indexed | 2024-12-17T10:38:23Z |
| format | Article |
| id | doaj.art-000456100ab04af0bed6425c96ba1fb4 |
| institution | Directory Open Access Journal |
| issn | 1179-1535 |
| language | English |
| last_indexed | 2024-12-17T10:38:23Z |
| publishDate | 2016-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Hepatic Medicine: Evidence and Research |
| spelling | doaj.art-000456100ab04af0bed6425c96ba1fb42022-12-21T21:52:19ZengDove Medical PressHepatic Medicine: Evidence and Research1179-15352016-01-012016Issue 11825272Challenging hepatitis C-infected liver transplant patientsOliver MChiodo Ortiz COrtiz JMadeleine Oliver,1 Christopher Chiodo Ortiz,2 Jorge Ortiz31University of Toledo College of Medicine, Toledo, OH, 2Bucknell University, Lewisburg, PA, 3Department of Transplant Surgery, University of Toledo Medical Center, Toledo, OH, USA Abstract: Caring for liver transplant patients suffering from chronic hepatitis C virus (HCV) infection is a challenging task for transplant surgeons and primary physicians alike. HCV is the leading cause of liver transplantation in the USA and comes with a myriad of complications that increase morbidity and mortality. This review focuses on patient follow-up, spanning from before the liver transplant occurs to the patient's long-term health. Pretransplant, both donor and recipient variables, must be carefully chosen to ensure optimal surgical success. Risk factors must be identified and HCV viral load must be reduced to a minimum. In addition to standard transplant complications, HCV patients suffer from additional problems, such as fibrosing cholestatic hepatitis and widespread viremia. Physicians must focus on the balance of immunosuppressive and antiviral medications, while considering possible side effects from these potent drugs. Over the years following surgery, physicians must identify any signs of failing liver health, as HCV-positive patients have an increased risk for cirrhosis and certain life-threatening malignancies. Keywords: liver transplant, hepatitis C virus, postoperative, cirrhosis, donor and recipient variables, viremiahttps://www.dovepress.com/challenging-hepatitis-c-infected-liver-transplant-patients-peer-reviewed-article-HMERLiver transplantHepatitis C Viruspostoperative |
| spellingShingle | Oliver M Chiodo Ortiz C Ortiz J Challenging hepatitis C-infected liver transplant patients Hepatic Medicine: Evidence and Research Liver transplant Hepatitis C Virus postoperative |
| title | Challenging hepatitis C-infected liver transplant patients |
| title_full | Challenging hepatitis C-infected liver transplant patients |
| title_fullStr | Challenging hepatitis C-infected liver transplant patients |
| title_full_unstemmed | Challenging hepatitis C-infected liver transplant patients |
| title_short | Challenging hepatitis C-infected liver transplant patients |
| title_sort | challenging hepatitis c infected liver transplant patients |
| topic | Liver transplant Hepatitis C Virus postoperative |
| url | https://www.dovepress.com/challenging-hepatitis-c-infected-liver-transplant-patients-peer-reviewed-article-HMER |
| work_keys_str_mv | AT oliverm challenginghepatitiscinfectedlivertransplantpatients AT chiodoortizc challenginghepatitiscinfectedlivertransplantpatients AT ortizj challenginghepatitiscinfectedlivertransplantpatients |