AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects?
Background: Angiotensin II (Ang II) and the renal sympathetic nervous system exert a strong influence on renal sodium and water excretion. We tested the hypothesis that already low doses of an Ang II inhibitor (candesartan) will result in similar effects on tubular sodium and water reabsorption in c...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-05-01
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| Series: | Kidney & Blood Pressure Research |
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| Online Access: | https://www.karger.com/Article/FullText/515616 |
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| author | Kristina Rodionova Martin Hindermann Karl Hilgers Christian Ott Roland E. Schmieder Mario Schiffer Kerstin Amann Roland Veelken Tilmann Ditting |
| author_facet | Kristina Rodionova Martin Hindermann Karl Hilgers Christian Ott Roland E. Schmieder Mario Schiffer Kerstin Amann Roland Veelken Tilmann Ditting |
| author_sort | Kristina Rodionova |
| collection | DOAJ |
| description | Background: Angiotensin II (Ang II) and the renal sympathetic nervous system exert a strong influence on renal sodium and water excretion. We tested the hypothesis that already low doses of an Ang II inhibitor (candesartan) will result in similar effects on tubular sodium and water reabsorption in congestive heart failure (CHF) as seen after renal denervation (DNX). Methods: Measurement of arterial blood pressure, heart rate (HR), renal sympathetic nerve activity (RSNA), glomerular filtration rate (GFR), renal plasma flow (RPF), urine volume, and urinary sodium. To assess neural control of volume homeostasis, 21 days after the induction of CHF via myocardial infarction rats underwent volume expansion (0.9% NaCL; 10% body weight) to decrease RSNA. CHF rat and controls with or without DNX or pretreated with the Ang II type-1 receptor antagonist candesartan (0.5 ug i.v.) were studied. Results: CHF rats excreted only 68 + 10.2% of the volume load (10% body weight) in 90 min. CHF rats pretreated with candesartan or after DNX excreted from 92 to 103% like controls. Decreases of RSNA induced by volume expansion were impaired in CHF rats but unaffected by candesartan pointing to an intrarenal drug effect. GFR and RPF were not significantly different in controls or CHF. Conclusion: The prominent function of increased RSNA – retaining salt and water – could no longer be observed after renal Ang II receptor blockade in CHF rats. |
| first_indexed | 2024-12-20T22:39:55Z |
| format | Article |
| id | doaj.art-0006588f374e4753abe2f62943430eae |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-20T22:39:55Z |
| publishDate | 2021-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-0006588f374e4753abe2f62943430eae2022-12-21T19:24:29ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432021-05-0146333134110.1159/000515616515616AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects?Kristina Rodionova0Martin Hindermann1Karl Hilgers2Christian Ott3Roland E. Schmieder4Mario Schiffer5Kerstin Amann6Roland Veelken7https://orcid.org/0000-0002-4254-6322Tilmann Ditting8Department of Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, GermanyDepartment of Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, GermanyDepartment of Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, GermanyDepartment of Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, GermanyDepartment of Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, GermanyDepartment of Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, GermanyDepartment of Nephropathology, University of Erlangen, Erlangen, GermanyDepartment of Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, GermanyDepartment of Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, GermanyBackground: Angiotensin II (Ang II) and the renal sympathetic nervous system exert a strong influence on renal sodium and water excretion. We tested the hypothesis that already low doses of an Ang II inhibitor (candesartan) will result in similar effects on tubular sodium and water reabsorption in congestive heart failure (CHF) as seen after renal denervation (DNX). Methods: Measurement of arterial blood pressure, heart rate (HR), renal sympathetic nerve activity (RSNA), glomerular filtration rate (GFR), renal plasma flow (RPF), urine volume, and urinary sodium. To assess neural control of volume homeostasis, 21 days after the induction of CHF via myocardial infarction rats underwent volume expansion (0.9% NaCL; 10% body weight) to decrease RSNA. CHF rat and controls with or without DNX or pretreated with the Ang II type-1 receptor antagonist candesartan (0.5 ug i.v.) were studied. Results: CHF rats excreted only 68 + 10.2% of the volume load (10% body weight) in 90 min. CHF rats pretreated with candesartan or after DNX excreted from 92 to 103% like controls. Decreases of RSNA induced by volume expansion were impaired in CHF rats but unaffected by candesartan pointing to an intrarenal drug effect. GFR and RPF were not significantly different in controls or CHF. Conclusion: The prominent function of increased RSNA – retaining salt and water – could no longer be observed after renal Ang II receptor blockade in CHF rats.https://www.karger.com/Article/FullText/515616renal sympathetic innervationangiotensin iicongestive heart failurerenal nerve ablationrenal function |
| spellingShingle | Kristina Rodionova Martin Hindermann Karl Hilgers Christian Ott Roland E. Schmieder Mario Schiffer Kerstin Amann Roland Veelken Tilmann Ditting AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects? Kidney & Blood Pressure Research renal sympathetic innervation angiotensin ii congestive heart failure renal nerve ablation renal function |
| title | AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects? |
| title_full | AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects? |
| title_fullStr | AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects? |
| title_full_unstemmed | AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects? |
| title_short | AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects? |
| title_sort | at ii receptor blockade and renal denervation different interventions with comparable renal effects |
| topic | renal sympathetic innervation angiotensin ii congestive heart failure renal nerve ablation renal function |
| url | https://www.karger.com/Article/FullText/515616 |
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