Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control study
AbstractBackground:Systemic immune-inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and systemic immune-inflammatory index (SII) are associated with the prognosis of many cardiovascular and neoplastic diseases....
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2269368 |
| _version_ | 1797302109991862272 |
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| author | Wei Liu Chenglong Liu Xiaofan Yu Yuanren Zhai Qiheng He Junsheng Li Xingju Liu Xun Ye Qian Zhang Rong Wang Yan Zhang Peicong Ge Dong Zhang |
| author_facet | Wei Liu Chenglong Liu Xiaofan Yu Yuanren Zhai Qiheng He Junsheng Li Xingju Liu Xun Ye Qian Zhang Rong Wang Yan Zhang Peicong Ge Dong Zhang |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | AbstractBackground:Systemic immune-inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and systemic immune-inflammatory index (SII) are associated with the prognosis of many cardiovascular and neoplastic diseases. Moyamoya disease (MMD) is associated with inflammation, but the relationship between systemic immune-inflammatory markers between MMD is unclear. The aim of our study was to analyse the association between systemic immune-inflammatory markers and the risk of MMD and its subtypes.Methods:We consecutively recruited 360 patients with MMD and 89 healthy control subjects in a case-control study to calculate and analyse the association of systemic immune-inflammatory markers with the risk of MMD and its subtypes.Results:The risk of MMD increased with higher levels of NLR (OR 1.237, 95% CI [1.008, 1.520], p = .042). When NLR and SII were assessed as quartile-spaced subgroups, the third quartile grouping of NLR and SII had a higher risk of MMD than the first quartile grouping (NLR: OR 3.206, 95% CI [1.271, 8.088], p = .014; SII: OR 3.074,95% CI [1.232,7.672], p = .016). When NLR was combined with SII, the highest subgroup had a higher risk of MMD than the lowest subgroup (OR2.643, 95% CI [1.340, 5.212], p = .005). The risk of subtypes also increased with higher levels of NLR and SII. The association between the levels of NLR and SII with the staging of the Suzuki stage follows an inverted U-shape. The highest levels of NLR and SII were found in patients with MMD at Suzuki stages 3–4.Conclusion:The risk of MMD increases with elevated systemic immune-inflammatory markers. This study analysed the association of systemic immune-inflammatory markers with the risk of developing MMD and its subtypes, and identified novel inflammatory markers for MMD. |
| first_indexed | 2024-03-07T23:32:09Z |
| format | Article |
| id | doaj.art-0006fef9b4944e94ab86e988359d9ea6 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-07T23:32:09Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-0006fef9b4944e94ab86e988359d9ea62024-02-20T11:58:25ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155210.1080/07853890.2023.2269368Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control studyWei Liu0Chenglong Liu1Xiaofan Yu2Yuanren Zhai3Qiheng He4Junsheng Li5Xingju Liu6Xun Ye7Qian Zhang8Rong Wang9Yan Zhang10Peicong Ge11Dong Zhang12Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaAbstractBackground:Systemic immune-inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and systemic immune-inflammatory index (SII) are associated with the prognosis of many cardiovascular and neoplastic diseases. Moyamoya disease (MMD) is associated with inflammation, but the relationship between systemic immune-inflammatory markers between MMD is unclear. The aim of our study was to analyse the association between systemic immune-inflammatory markers and the risk of MMD and its subtypes.Methods:We consecutively recruited 360 patients with MMD and 89 healthy control subjects in a case-control study to calculate and analyse the association of systemic immune-inflammatory markers with the risk of MMD and its subtypes.Results:The risk of MMD increased with higher levels of NLR (OR 1.237, 95% CI [1.008, 1.520], p = .042). When NLR and SII were assessed as quartile-spaced subgroups, the third quartile grouping of NLR and SII had a higher risk of MMD than the first quartile grouping (NLR: OR 3.206, 95% CI [1.271, 8.088], p = .014; SII: OR 3.074,95% CI [1.232,7.672], p = .016). When NLR was combined with SII, the highest subgroup had a higher risk of MMD than the lowest subgroup (OR2.643, 95% CI [1.340, 5.212], p = .005). The risk of subtypes also increased with higher levels of NLR and SII. The association between the levels of NLR and SII with the staging of the Suzuki stage follows an inverted U-shape. The highest levels of NLR and SII were found in patients with MMD at Suzuki stages 3–4.Conclusion:The risk of MMD increases with elevated systemic immune-inflammatory markers. This study analysed the association of systemic immune-inflammatory markers with the risk of developing MMD and its subtypes, and identified novel inflammatory markers for MMD.https://www.tandfonline.com/doi/10.1080/07853890.2023.2269368Systemic immune-inflammatory markersmoyamoya diseaseneutrophil-to-lymphocyte ratiosystemic immune-inflammatory indexSuzuki stage |
| spellingShingle | Wei Liu Chenglong Liu Xiaofan Yu Yuanren Zhai Qiheng He Junsheng Li Xingju Liu Xun Ye Qian Zhang Rong Wang Yan Zhang Peicong Ge Dong Zhang Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control study Annals of Medicine Systemic immune-inflammatory markers moyamoya disease neutrophil-to-lymphocyte ratio systemic immune-inflammatory index Suzuki stage |
| title | Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control study |
| title_full | Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control study |
| title_fullStr | Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control study |
| title_full_unstemmed | Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control study |
| title_short | Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control study |
| title_sort | association between systemic immune inflammatory markers and the risk of moyamoya disease a case control study |
| topic | Systemic immune-inflammatory markers moyamoya disease neutrophil-to-lymphocyte ratio systemic immune-inflammatory index Suzuki stage |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2269368 |
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