Ovarian cancer treatment and natural killer cell-based immunotherapy
BackgroundOvarian cancer (OC) is one of the malignant tumors that poses a serious threat to women’s health. Natural killer (NK) cells are an integral part of the immune system and have the ability to kill tumor cells directly or participate indirectly in the anti-tumor immune response. In recent yea...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1308143/full |
| _version_ | 1797384254391320576 |
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| author | Zhongru Fan Dongyu Han Xin Fan Lin Zhao |
| author_facet | Zhongru Fan Dongyu Han Xin Fan Lin Zhao |
| author_sort | Zhongru Fan |
| collection | DOAJ |
| description | BackgroundOvarian cancer (OC) is one of the malignant tumors that poses a serious threat to women’s health. Natural killer (NK) cells are an integral part of the immune system and have the ability to kill tumor cells directly or participate indirectly in the anti-tumor immune response. In recent years, NK cell-based immunotherapy for OC has shown remarkable potential. However, its mechanisms and effects remain unclear when compared to standard treatment.MethodsTo explore the value of NK cell-based immunotherapy in the treatment of OC, we conducted a literature review. In comparison to standard treatment, our focus was primarily on the current anti-tumor mechanisms, the clinical effect of NK cells against OC, factors affecting the structure and function of NK cells, and strategies to enhance the effectiveness of NK cells.ResultsWe found that NK cells exert their therapeutic effects in OC through mechanisms such as antibody-dependent cell cytotoxicity, perforin release, and granule enzyme secretion. They also secrete IFN-γ and TNF-α or engage in Fas/FasL and TRAIL/TRAILR pathways, mediating the death of OC cells. In clinical trials, the majority of patients experienced disease stability with mild side effects after receiving NK cell-based immunotherapy, but there is still a lack of high-quality research evidence regarding its clinical effectiveness. OC and prior experience with standard treatments have an effect on NK cells, and it may be considered to maximize NK cell effects through the modulation of the tumor microenvironment or combination with other therapies.ConclusionsIn this review, we have summarized the current evidence of NK cell applications in the treatment of OC. Furthermore, factors and strategies that influence and enhance the role of NK cell immunotherapy are discussed. |
| first_indexed | 2024-03-08T21:32:47Z |
| format | Article |
| id | doaj.art-000712ff6d344b31a5a5c87a923baa04 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T21:32:47Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-000712ff6d344b31a5a5c87a923baa042023-12-21T04:20:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.13081431308143Ovarian cancer treatment and natural killer cell-based immunotherapyZhongru Fan0Dongyu Han1Xin Fan2Lin Zhao3Department of Urology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Obstetrics and Gynecology, Suzhou Hospital, Affiliated Hospital of Meddical School, Nanjing University, Suzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Obstetrics and Gynecology, Suzhou Hospital, Affiliated Hospital of Meddical School, Nanjing University, Suzhou, ChinaBackgroundOvarian cancer (OC) is one of the malignant tumors that poses a serious threat to women’s health. Natural killer (NK) cells are an integral part of the immune system and have the ability to kill tumor cells directly or participate indirectly in the anti-tumor immune response. In recent years, NK cell-based immunotherapy for OC has shown remarkable potential. However, its mechanisms and effects remain unclear when compared to standard treatment.MethodsTo explore the value of NK cell-based immunotherapy in the treatment of OC, we conducted a literature review. In comparison to standard treatment, our focus was primarily on the current anti-tumor mechanisms, the clinical effect of NK cells against OC, factors affecting the structure and function of NK cells, and strategies to enhance the effectiveness of NK cells.ResultsWe found that NK cells exert their therapeutic effects in OC through mechanisms such as antibody-dependent cell cytotoxicity, perforin release, and granule enzyme secretion. They also secrete IFN-γ and TNF-α or engage in Fas/FasL and TRAIL/TRAILR pathways, mediating the death of OC cells. In clinical trials, the majority of patients experienced disease stability with mild side effects after receiving NK cell-based immunotherapy, but there is still a lack of high-quality research evidence regarding its clinical effectiveness. OC and prior experience with standard treatments have an effect on NK cells, and it may be considered to maximize NK cell effects through the modulation of the tumor microenvironment or combination with other therapies.ConclusionsIn this review, we have summarized the current evidence of NK cell applications in the treatment of OC. Furthermore, factors and strategies that influence and enhance the role of NK cell immunotherapy are discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1308143/fullovarian cancernatural killer cellsimmunotherapycytokinesFas/FasLTRAIL/TRAILR |
| spellingShingle | Zhongru Fan Dongyu Han Xin Fan Lin Zhao Ovarian cancer treatment and natural killer cell-based immunotherapy Frontiers in Immunology ovarian cancer natural killer cells immunotherapy cytokines Fas/FasL TRAIL/TRAILR |
| title | Ovarian cancer treatment and natural killer cell-based immunotherapy |
| title_full | Ovarian cancer treatment and natural killer cell-based immunotherapy |
| title_fullStr | Ovarian cancer treatment and natural killer cell-based immunotherapy |
| title_full_unstemmed | Ovarian cancer treatment and natural killer cell-based immunotherapy |
| title_short | Ovarian cancer treatment and natural killer cell-based immunotherapy |
| title_sort | ovarian cancer treatment and natural killer cell based immunotherapy |
| topic | ovarian cancer natural killer cells immunotherapy cytokines Fas/FasL TRAIL/TRAILR |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1308143/full |
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