Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α–XBP1 Axis in HepG2 Cells

Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α–XBP1 Axis in HepG2 Cells

Emodin, an emerging mycotoxin, is known to be hepatotoxic, but its mechanism remains unclear. We hypothesized that emodin could induce endoplasmic reticulum (ER) stress through the inositol-requiring enzyme 1 alpha (IRE1α)–X-box-binding protein 1 (XBP1) pathway and apoptosis, which are closely corre...

Full description

Bibliographic Details
Main Authors: Su Been Park, Gun Hee Cho, Young Eun Park, Hyang Sook Chun
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Toxins
Subjects:
emodin
mycotoxin
ER stress
apoptosis
HepG2 cells
hepatotoxicity
Online Access:https://www.mdpi.com/2072-6651/15/7/455

Similar Items

Similar Items