Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia
Gelagey Baye Temesgen,1 Menakath Menon,2 Solomon Tebeje Gizaw,2 Bayu Wondimneh Yimenu,1 Melaku Mekonen Agidew3 1Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Medical Biochemistry School of Medicine, College of Health Sciences Addis Ababa Universit...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-01-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/evaluation-of-lipid-profile-and-inflammatory-marker-in-patients-with-g-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818968363783684096 |
|---|---|
| author | Temesgen GB Menon M Gizaw ST Yimenu BW Agidew MM |
| author_facet | Temesgen GB Menon M Gizaw ST Yimenu BW Agidew MM |
| author_sort | Temesgen GB |
| collection | DOAJ |
| description | Gelagey Baye Temesgen,1 Menakath Menon,2 Solomon Tebeje Gizaw,2 Bayu Wondimneh Yimenu,1 Melaku Mekonen Agidew3 1Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Medical Biochemistry School of Medicine, College of Health Sciences Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Medical Biochemistry, School of Medicine, Debre Tabor University, Debre Tabor, EthiopiaCorrespondence: Gelagey Baye Temesgen Tel +251 918479703Fax +251 587780673Email gelagaybaye@gmail.comIntroduction: H. pylori are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. To assess cardiovascular risk factors and to predict cardiovascular disorders, we are evaluating and comparing lipid profile and inflammatory marker between H. pylori-positive and negative patients.Objective: To evaluate and compare lipid profile (TC; TG; LDL; HDL) and inflammatory marker (hs-CRP) in dyspeptic patients with and without H. pylori infection.Methods: Comparative cross-sectional study was conducted from September 2020 to January 2021 at Debre Markos Referral Hospital, Debre Markos Health Center, and Hidassie Health Center, Ethiopia. Each of 50 H. pylori-positive and negative dyspeptic patients were studied. The data were checked for completeness and analyzed by SPSS version 25.0 Software. A p-value < 0.05 was considered statistically significant.Results: Serum mean high-density lipoprotein (HDL) values were 37.54 ± 7.98 mg/dL and 43.12 ± 7.86 mg/dL (p < 0.05) for H. pylori-positive and negative dyspeptic patients, respectively, and median serum high sensitive C reactive protein (hs-CRP) levels were 6.29 mg/L (1.66– 41.34) and 3.35 mg/L (0.39– 10.01) (p < 0.05) for H. pylori-positive and negative dyspeptic patients, respectively.Conclusion: H. pylori infection significantly alters serum high-density lipoprotein (HDL) and high sensitive C reactive protein (hs-CRP) levels in dyspeptic patients, as a result, increase the potential risk of cardiovascular diseases.Keywords: H. pylori, dyspepsia, lipid profile, hs-CRP, inflammation, cardiovascular diseases |
| first_indexed | 2024-12-20T14:03:30Z |
| format | Article |
| id | doaj.art-000a5e25bc6e4bdba07a4623d3b1cdd6 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-20T14:03:30Z |
| publishDate | 2022-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-000a5e25bc6e4bdba07a4623d3b1cdd62022-12-21T19:38:18ZengDove Medical PressInternational Journal of General Medicine1178-70742022-01-01Volume 1527127872104Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, EthiopiaTemesgen GBMenon MGizaw STYimenu BWAgidew MMGelagey Baye Temesgen,1 Menakath Menon,2 Solomon Tebeje Gizaw,2 Bayu Wondimneh Yimenu,1 Melaku Mekonen Agidew3 1Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Medical Biochemistry School of Medicine, College of Health Sciences Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Medical Biochemistry, School of Medicine, Debre Tabor University, Debre Tabor, EthiopiaCorrespondence: Gelagey Baye Temesgen Tel +251 918479703Fax +251 587780673Email gelagaybaye@gmail.comIntroduction: H. pylori are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. To assess cardiovascular risk factors and to predict cardiovascular disorders, we are evaluating and comparing lipid profile and inflammatory marker between H. pylori-positive and negative patients.Objective: To evaluate and compare lipid profile (TC; TG; LDL; HDL) and inflammatory marker (hs-CRP) in dyspeptic patients with and without H. pylori infection.Methods: Comparative cross-sectional study was conducted from September 2020 to January 2021 at Debre Markos Referral Hospital, Debre Markos Health Center, and Hidassie Health Center, Ethiopia. Each of 50 H. pylori-positive and negative dyspeptic patients were studied. The data were checked for completeness and analyzed by SPSS version 25.0 Software. A p-value < 0.05 was considered statistically significant.Results: Serum mean high-density lipoprotein (HDL) values were 37.54 ± 7.98 mg/dL and 43.12 ± 7.86 mg/dL (p < 0.05) for H. pylori-positive and negative dyspeptic patients, respectively, and median serum high sensitive C reactive protein (hs-CRP) levels were 6.29 mg/L (1.66– 41.34) and 3.35 mg/L (0.39– 10.01) (p < 0.05) for H. pylori-positive and negative dyspeptic patients, respectively.Conclusion: H. pylori infection significantly alters serum high-density lipoprotein (HDL) and high sensitive C reactive protein (hs-CRP) levels in dyspeptic patients, as a result, increase the potential risk of cardiovascular diseases.Keywords: H. pylori, dyspepsia, lipid profile, hs-CRP, inflammation, cardiovascular diseaseshttps://www.dovepress.com/evaluation-of-lipid-profile-and-inflammatory-marker-in-patients-with-g-peer-reviewed-fulltext-article-IJGMh. pyloridyspepsialipid profilehs-crpinflammationcardiovascular diseases |
| spellingShingle | Temesgen GB Menon M Gizaw ST Yimenu BW Agidew MM Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia International Journal of General Medicine h. pylori dyspepsia lipid profile hs-crp inflammation cardiovascular diseases |
| title | Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia |
| title_full | Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia |
| title_fullStr | Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia |
| title_full_unstemmed | Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia |
| title_short | Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia |
| title_sort | evaluation of lipid profile and inflammatory marker in patients with gastric helicobacter pylori infection ethiopia |
| topic | h. pylori dyspepsia lipid profile hs-crp inflammation cardiovascular diseases |
| url | https://www.dovepress.com/evaluation-of-lipid-profile-and-inflammatory-marker-in-patients-with-g-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT temesgengb evaluationoflipidprofileandinflammatorymarkerinpatientswithgastrichelicobacterpyloriinfectionethiopia AT menonm evaluationoflipidprofileandinflammatorymarkerinpatientswithgastrichelicobacterpyloriinfectionethiopia AT gizawst evaluationoflipidprofileandinflammatorymarkerinpatientswithgastrichelicobacterpyloriinfectionethiopia AT yimenubw evaluationoflipidprofileandinflammatorymarkerinpatientswithgastrichelicobacterpyloriinfectionethiopia AT agidewmm evaluationoflipidprofileandinflammatorymarkerinpatientswithgastrichelicobacterpyloriinfectionethiopia |