Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections
Herpesviruses utilize various host factors to establish latent infection, survival, and spread disease in the host. These factors include host cellular machinery, host proteins, gene expression, multiple transcription factors, cellular signal pathways, immune cell activation, transcription factors,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.603309/full |
| _version_ | 1819159553675100160 |
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| author | Kumari Asha Neelam Sharma-Walia |
| author_facet | Kumari Asha Neelam Sharma-Walia |
| author_sort | Kumari Asha |
| collection | DOAJ |
| description | Herpesviruses utilize various host factors to establish latent infection, survival, and spread disease in the host. These factors include host cellular machinery, host proteins, gene expression, multiple transcription factors, cellular signal pathways, immune cell activation, transcription factors, cytokines, angiogenesis, invasion, and factors promoting metastasis. The knowledge and understanding of host genes, protein products, and biochemical pathways lead to discovering safe and effective antivirals to prevent viral reactivation and spread infection. Here, we focus on the contribution of pro-inflammatory, anti-inflammatory, and resolution lipid metabolites of the arachidonic acid (AA) pathway in the lifecycle of herpesvirus infections. We discuss how various herpesviruses utilize these lipid pathways to their advantage and how we target them to combat herpesvirus infection. We also summarize recent development in anti-herpesvirus therapeutics and new strategies proposed or under clinical trials. These anti-herpesvirus therapeutics include inhibitors blocking viral life cycle events, engineered anticancer agents, epigenome influencing factors, immunomodulators, and therapeutic compounds from natural extracts. |
| first_indexed | 2024-12-22T16:42:23Z |
| format | Article |
| id | doaj.art-000bb3c233454c658bcaec7d925ecd87 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-22T16:42:23Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-000bb3c233454c658bcaec7d925ecd872022-12-21T18:19:48ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-03-011110.3389/fcimb.2021.603309603309Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus InfectionsKumari AshaNeelam Sharma-WaliaHerpesviruses utilize various host factors to establish latent infection, survival, and spread disease in the host. These factors include host cellular machinery, host proteins, gene expression, multiple transcription factors, cellular signal pathways, immune cell activation, transcription factors, cytokines, angiogenesis, invasion, and factors promoting metastasis. The knowledge and understanding of host genes, protein products, and biochemical pathways lead to discovering safe and effective antivirals to prevent viral reactivation and spread infection. Here, we focus on the contribution of pro-inflammatory, anti-inflammatory, and resolution lipid metabolites of the arachidonic acid (AA) pathway in the lifecycle of herpesvirus infections. We discuss how various herpesviruses utilize these lipid pathways to their advantage and how we target them to combat herpesvirus infection. We also summarize recent development in anti-herpesvirus therapeutics and new strategies proposed or under clinical trials. These anti-herpesvirus therapeutics include inhibitors blocking viral life cycle events, engineered anticancer agents, epigenome influencing factors, immunomodulators, and therapeutic compounds from natural extracts.https://www.frontiersin.org/articles/10.3389/fcimb.2021.603309/fullherpesviruslatencylyticarachidonic acidantiviral |
| spellingShingle | Kumari Asha Neelam Sharma-Walia Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections Frontiers in Cellular and Infection Microbiology herpesvirus latency lytic arachidonic acid antiviral |
| title | Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections |
| title_full | Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections |
| title_fullStr | Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections |
| title_full_unstemmed | Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections |
| title_short | Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections |
| title_sort | targeting host cellular factors as a strategy of therapeutic intervention for herpesvirus infections |
| topic | herpesvirus latency lytic arachidonic acid antiviral |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.603309/full |
| work_keys_str_mv | AT kumariasha targetinghostcellularfactorsasastrategyoftherapeuticinterventionforherpesvirusinfections AT neelamsharmawalia targetinghostcellularfactorsasastrategyoftherapeuticinterventionforherpesvirusinfections |