The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods—a cross-sectional design
Abstract Purpose During the last few decades, the increased use of various types of antibiotics in the general population caused a significant change in regional Helicobacter pylori (H. pylori) antibiotic resistance. Our aim is to study the changes in H. pylori resistance in patients who had undergo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01500-0 |
| _version_ | 1827635065342918656 |
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| author | Haim Shmuely Yekaterina Shvartsman Rita Berdinstein Jacob Yahav Ehud Melzer |
| author_facet | Haim Shmuely Yekaterina Shvartsman Rita Berdinstein Jacob Yahav Ehud Melzer |
| author_sort | Haim Shmuely |
| collection | DOAJ |
| description | Abstract Purpose During the last few decades, the increased use of various types of antibiotics in the general population caused a significant change in regional Helicobacter pylori (H. pylori) antibiotic resistance. Our aim is to study the changes in H. pylori resistance in patients who had undergone an esophagogastroduodenoscopy (EGD) and susceptibility testing and found positive for H. pylori. The study was conducted in a university affiliated hospital between 2013–2020. Methods A cross-sectional study was performed on all consecutive patients who had undergone an EGD and tested positive for H. pylori at the Kaplan Medical Center, Israel. The study period was divided into two sub-periods: 2013–2016 and 2017–2020. Data on age, sex, comorbidities, previous treatments, and antimicrobial susceptibility testing for six antimicrobial agents were compared. Results The resistance rates of H. pylori to clarithromycin and dual resistance to clarithromycin and metronidazole were found significantly higher during the late period. Multivariable analysis showed that the later period, older age, and diabetes mellitus were independent predictors for antimicrobial resistance. Conclusions Our study has shown that there is an increasing resistance of H. pylori to clarithromycin and metronidazole while its susceptibility is unaffected with time to other antibiotics. More recent cross-sectional studies with larger samples are warranted in order to evaluate the changes in the resistance patterns of H. pylori to various antibiotics with time. |
| first_indexed | 2024-03-09T15:22:01Z |
| format | Article |
| id | doaj.art-000c14ca34444c5baa69939d99dde9dc |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-09T15:22:01Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-000c14ca34444c5baa69939d99dde9dc2023-11-26T12:42:21ZengBMCEuropean Journal of Medical Research2047-783X2023-11-012811510.1186/s40001-023-01500-0The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods—a cross-sectional designHaim Shmuely0Yekaterina Shvartsman1Rita Berdinstein2Jacob Yahav3Ehud Melzer4Department of Internal Medicine D, and Helicobacter Research Institute, Kaplan Medical CenterDepartment of Internal Medicine D, and Helicobacter Research Institute, Kaplan Medical CenterMicrobiology Laboratory, Kaplan Medical CenterFaculty of Medicine, Hebrew UniversityFaculty of Medicine, Hebrew UniversityAbstract Purpose During the last few decades, the increased use of various types of antibiotics in the general population caused a significant change in regional Helicobacter pylori (H. pylori) antibiotic resistance. Our aim is to study the changes in H. pylori resistance in patients who had undergone an esophagogastroduodenoscopy (EGD) and susceptibility testing and found positive for H. pylori. The study was conducted in a university affiliated hospital between 2013–2020. Methods A cross-sectional study was performed on all consecutive patients who had undergone an EGD and tested positive for H. pylori at the Kaplan Medical Center, Israel. The study period was divided into two sub-periods: 2013–2016 and 2017–2020. Data on age, sex, comorbidities, previous treatments, and antimicrobial susceptibility testing for six antimicrobial agents were compared. Results The resistance rates of H. pylori to clarithromycin and dual resistance to clarithromycin and metronidazole were found significantly higher during the late period. Multivariable analysis showed that the later period, older age, and diabetes mellitus were independent predictors for antimicrobial resistance. Conclusions Our study has shown that there is an increasing resistance of H. pylori to clarithromycin and metronidazole while its susceptibility is unaffected with time to other antibiotics. More recent cross-sectional studies with larger samples are warranted in order to evaluate the changes in the resistance patterns of H. pylori to various antibiotics with time.https://doi.org/10.1186/s40001-023-01500-0Helicobacter pyloriAntimicrobial resistanceSingle hospitalPredictors for resistance |
| spellingShingle | Haim Shmuely Yekaterina Shvartsman Rita Berdinstein Jacob Yahav Ehud Melzer The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods—a cross-sectional design European Journal of Medical Research Helicobacter pylori Antimicrobial resistance Single hospital Predictors for resistance |
| title | The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods—a cross-sectional design |
| title_full | The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods—a cross-sectional design |
| title_fullStr | The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods—a cross-sectional design |
| title_full_unstemmed | The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods—a cross-sectional design |
| title_short | The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods—a cross-sectional design |
| title_sort | epidemiology of helicobacter pylori resistance in a university affiliated hospital a comparison between two time periods a cross sectional design |
| topic | Helicobacter pylori Antimicrobial resistance Single hospital Predictors for resistance |
| url | https://doi.org/10.1186/s40001-023-01500-0 |
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