Hyperuricemia and dementia – a case-control study
Abstract Background There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric acid (SUA) levels or hyperuricemia and dementia remains elusive. Most stud...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12883-018-1136-y |
| _version_ | 1818293959097581568 |
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| author | Bettina Engel Willy Gomm Karl Broich Wolfgang Maier Klaus Weckbecker Britta Haenisch |
| author_facet | Bettina Engel Willy Gomm Karl Broich Wolfgang Maier Klaus Weckbecker Britta Haenisch |
| author_sort | Bettina Engel |
| collection | DOAJ |
| description | Abstract Background There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric acid (SUA) levels or hyperuricemia and dementia remains elusive. Most studies focused on the disease or SUA levels. Effects of anti-hyperuricemic treatment have not been considered yet. This study investigated the association between hyperuricemia and dementia taking into account anti-hyperuricemic treatment. Methods We used longitudinal German public health insurance data and analyzed the association between hyperuricemia with and without different treatment options and dementia in a case-control design. Applying logistic regression the analysis was adjusted for several potential confounders including various comorbidities and polypharmacy. Results We identified 27,528 cases and 110,112 matched controls of which 22% had a diagnosis of hyperuricemia or gout and 17% received anti-hyperuricemic drugs. For patients with a diagnosis of hyperuricemia we found a slightly reduced risk for dementia (adjusted odds ratio [OR] 0.94, 95% confidence interval [CI] 0.89 to 0.98). The risk reduction was more pronounced for patients treated with anti-hyperuricemic drugs (adjusted OR 0.89, 95% CI 0.85 to 0.94, for regular treatment). Conclusions Our results showed a slight reduction for dementia risk in patients with hyperuricemia, both with and without anti-hyperuricemic treatment. |
| first_indexed | 2024-12-13T03:24:08Z |
| format | Article |
| id | doaj.art-000f6094bd0d4874b0661a51928e68e3 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-13T03:24:08Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-000f6094bd0d4874b0661a51928e68e32022-12-22T00:01:18ZengBMCBMC Neurology1471-23772018-08-011811710.1186/s12883-018-1136-yHyperuricemia and dementia – a case-control studyBettina Engel0Willy Gomm1Karl Broich2Wolfgang Maier3Klaus Weckbecker4Britta Haenisch5Institute of General Practice and Family Medicine, University of BonnGerman Center for Neurodegenerative Diseases (DZNE)Federal Institute for Drugs and Medical Devices (BfArM)German Center for Neurodegenerative Diseases (DZNE)Institute of General Practice and Family Medicine, University of BonnGerman Center for Neurodegenerative Diseases (DZNE)Abstract Background There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric acid (SUA) levels or hyperuricemia and dementia remains elusive. Most studies focused on the disease or SUA levels. Effects of anti-hyperuricemic treatment have not been considered yet. This study investigated the association between hyperuricemia and dementia taking into account anti-hyperuricemic treatment. Methods We used longitudinal German public health insurance data and analyzed the association between hyperuricemia with and without different treatment options and dementia in a case-control design. Applying logistic regression the analysis was adjusted for several potential confounders including various comorbidities and polypharmacy. Results We identified 27,528 cases and 110,112 matched controls of which 22% had a diagnosis of hyperuricemia or gout and 17% received anti-hyperuricemic drugs. For patients with a diagnosis of hyperuricemia we found a slightly reduced risk for dementia (adjusted odds ratio [OR] 0.94, 95% confidence interval [CI] 0.89 to 0.98). The risk reduction was more pronounced for patients treated with anti-hyperuricemic drugs (adjusted OR 0.89, 95% CI 0.85 to 0.94, for regular treatment). Conclusions Our results showed a slight reduction for dementia risk in patients with hyperuricemia, both with and without anti-hyperuricemic treatment.http://link.springer.com/article/10.1186/s12883-018-1136-yEpidemiologyGoutHyperuricemiaTreatmentDementia |
| spellingShingle | Bettina Engel Willy Gomm Karl Broich Wolfgang Maier Klaus Weckbecker Britta Haenisch Hyperuricemia and dementia – a case-control study BMC Neurology Epidemiology Gout Hyperuricemia Treatment Dementia |
| title | Hyperuricemia and dementia – a case-control study |
| title_full | Hyperuricemia and dementia – a case-control study |
| title_fullStr | Hyperuricemia and dementia – a case-control study |
| title_full_unstemmed | Hyperuricemia and dementia – a case-control study |
| title_short | Hyperuricemia and dementia – a case-control study |
| title_sort | hyperuricemia and dementia a case control study |
| topic | Epidemiology Gout Hyperuricemia Treatment Dementia |
| url | http://link.springer.com/article/10.1186/s12883-018-1136-y |
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