A new and expeditious synthesis of all enantiomerically pure stereoisomers of rosaprostol, an antiulcer drug

A new and expeditious synthesis of all enantiomerically pure stereoisomers of rosaprostol, an antiulcer drug

Four enantiomerically pure stereoisomers of rosaprostol (1), an antiulcer drug, were efficiently synthesized from the enantiomers of 2-(dimethoxyphosphoryl)-3-hexylcyclopentanone (3) as chiral substrates. The latter were obtained by resolution of racemic 3 with (+)-(R)-1-(1-naphthyl)ethylamine. The...

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Bibliographic Details
Main Authors: Wiesława Perlikowska, Remigiusz Żurawiński, Marian Mikołajczyk
Format: Article
Language:English
Published: Beilstein-Institut 2016-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
antiulcer drug
chiral resolution
rosaprostol
stereoselective synthesis
synthetic design
Online Access:https://doi.org/10.3762/bjoc.12.215

Internet

https://doi.org/10.3762/bjoc.12.215

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