Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression

Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression

Cancer cells change their glucose and glutamine (GLU) metabolism to obtain the energy required to continue growing. Glutaminase (GLS) plays a crucial role in promoting cell metabolism for cancer cell growth; targeting GLU metabolism by inhibiting GLS has attracted interest as a potential cancer mana...

Full description

Bibliographic Details
Main Authors:	Shams Tabrez, Torki A. Zughaibi, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Azhar U. Khan
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Series:	Molecules
Subjects:	glutamine cancer glutaminase natural compounds
Online Access:	https://www.mdpi.com/1420-3049/27/15/5042

Similar Items

Brain glutaminases
by: Márquez Javier, et al.
Published: (2010-05-01)

Correction: Tabrez et al. Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression. <i>Molecules</i> 2022, <i>27</i>, 5042
by: Shams Tabrez, et al.
Published: (2022-12-01)

Safety evaluation of the food enzyme glutaminase from the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT
by: EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), et al.
Published: (2024-02-01)

Glutamine and leukemia research: progress and clinical prospects
by: Zexin Wang, et al.
Published: (2024-08-01)

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer
by: Dean C. Singleton, et al.
Published: (2020-05-01)

Research Progress in Improving Efficacy of Radiotherapy by Targeting Glutamine Metabolism
by: QIAO Wanjia, et al.
Published: (2023-03-01)

Screening of Bacteria Producing Asparaginase Free of Glutaminase and Urease from Hot Springs in West Sulawesi
by: Ruby Setiawan, et al.
Published: (2019-08-01)

Self-Assembled Micellar Glutaminase Allosteric Inhibitor for Effective Therapeutic Intervention
by: Fang J, et al.
Published: (2022-01-01)

SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS
by: Federica Barreca, et al.
Published: (2023-08-01)

Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets
by: Ding Nan, et al.
Published: (2025-01-01)

Therapeutic Potential of Glutamine Pathway in Lung Cancer
by: Enyu Tang, et al.
Published: (2022-02-01)

Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
by: Tian Ruimin, et al.
Published: (2023-09-01)

Evaluating Therapeutic Characteristics of Anticancer L -Glutaminase Enzyme on Ethylenimine Induced Mutagens in Rats.
by: Gulbahar Karim, et al.
Published: (2018-12-01)

Dual targeting of EGFR and glutaminase in lung cancer
by: Milica Momcilovic, et al.
Published: (2018-05-01)

Identification of anticancer bioactive compounds derived from Ficus sp. by targeting Poly[ADP-ribose]polymerase 1 (PARP-1)
by: Shams Tabrez, et al.
Published: (2022-07-01)

Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease
by: Ge Gao, et al.
Published: (2019-06-01)

Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
by: Shams Tabrez, et al.
Published: (2022-09-01)

BIX01294 suppresses PDAC growth through inhibition of glutaminase-mediated glutathione dynamics
by: Se Seul Im, et al.
Published: (2025-04-01)

Glutamine metabolism, a double agent combating or fuelling hepatocellular carcinomaKey points
by: Razan Abou Ziki, et al.
Published: (2024-05-01)

Effect of Protein Glutaminase on the Interface Properties of Zein
by: Xingli LIU, et al.
Published: (2025-03-01)

TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
by: Kaizhe Wang, et al.
Published: (2017-04-01)

Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release
by: Ge Gao, et al.
Published: (2020-02-01)

Glutaminase 1 isoform up-regulation associated with lipid metabolism disorder induced by methyl tertiary-butyl ether in male rats
by: Mingxiao Guo, et al.
Published: (2023-04-01)

SCREENING AND CHARACTERIZATION OF L-GLUTAMINASE PRODUCED BY BACTERIA ISOLATED FROM SANGIHE TALAUD SEA
by: Ekowati Chasanah, et al.
Published: (2013-05-01)

RNAi-mediated silencing of Trichinella spiralis glutaminase results in reduced muscle larval infectivity
by: Yuan Gao, et al.
Published: (2021-03-01)

Evidence of Antioxidant Activity of Novel L-Glutaminase Purified from L. Gasseri BRLHM
by: Butheina Hasson, et al.
Published: (2021-12-01)

Neonatal Encephalopathy due to Glutaminase Deficiency in a Neonate
by: Unnati Achanta, et al.
Published: (2024-11-01)

Effect of glutaminase inhibition on cancer-induced bone pain
by: Fazzari J, et al.
Published: (2019-09-01)

GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells
by: Juan De los Santos-Jiménez, et al.
Published: (2024-06-01)

Biosynthesis of ZnO NPs from pumpkin seeds’ extract and elucidation of its anticancer potential against breast cancer
by: Tabrez Shams, et al.
Published: (2022-08-01)

Kidney-type glutaminase is a biomarker for the diagnosis and prognosis of hepatocellular carcinoma: a prospective study
by: Laizhu Zhang, et al.
Published: (2023-11-01)

Immunogenicity assessment of antileukemic agent glutaminase from Escherichia coli, Pseudomonas sp., and Bacillus sp.
by: Jyotsna Parmar, et al.
Published: (2022-01-01)

SNAP25 Inhibits Glioma Progression by Regulating Synapse Plasticity via GLS-Mediated Glutaminolysis
by: Qiongzhen Huang, et al.
Published: (2021-08-01)

P2X7 Receptor Augments LPS-Induced Nitrosative Stress by Regulating Nrf2 and GSH Levels in the Mouse Hippocampus
by: Duk-Shin Lee, et al.
Published: (2022-04-01)

Safety evaluation of the food enzyme glutaminase from the genetically modified Bacillus licheniformis strain NZYM‐JQ
by: EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), et al.
Published: (2024-04-01)

Glutaminase inhibition as potential cancer therapeutics: current status and future applications
by: Rajath Cyriac, et al.
Published: (2024-12-01)

Immobilization of Vibrio cholerae S1 (NAG) L-Glutaminase on Different Supports
by: Shatha Salman Hassan
Published: (2010-06-01)

The effect of rehabilitation exercise on the expression of glutaminase and cardiopulmonary remodeling in pulmonary hypertension
by: Shang Wang, et al.
Published: (2022-09-01)

Production, characterization, and antitumor efficiency of l-glutaminase from halophilic bacteria
by: Eman Zakaria Gomaa
Published: (2022-01-01)

Glutamate Metabolism in Brain Structures in Experimental Hemorrhagic Shock
by: V. N. Jakovlev, et al.
Published: (2017-03-01)