Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis

Abstract Numerous studies have proven the critical role of macrophages in the renal fibrosis process. Notably, G Protein-coupled Estrogen Receptor 1 (GPER1), a novel estrogen receptor, has been shown to play a ubiquitous role in regulating macrophage activities and proinflammatory pathways. However,...

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Bibliographic Details
Main Authors: Lin Xie, Ye Cheng, Wen Du, Lili Fu, Zhaonan Wei, Yuting Guan, Yi Wang, Changlin Mei, Chuanming Hao, Min Chen, Xiangchen Gu
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06338-2