Quantitative RT-PCR Assays for Quantification of Undesirable Mutants in the Novel Type 2 Oral Poliovirus Vaccine

Quantitative RT-PCR Assays for Quantification of Undesirable Mutants in the Novel Type 2 Oral Poliovirus Vaccine

Emergence of mutations is an inherent property of RNA viruses with several implications for their replication, pathogenesis, and evolutionary adaptation. Oral poliovirus vaccine (OPV), developed by Albert Sabin, is composed of live attenuated polioviruses of three serotypes that can revert to neurov...

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Bibliographic Details
Main Authors: Hasmik Manukyan, Rahnuma Wahid, Azeem Ansari, Erman Tritama, Andrew Macadam, John Konz, Konstantin Chumakov, Majid Laassri
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Vaccines
Subjects:
OPV
nOPV2
quality control
mutant variants
Online Access:https://www.mdpi.com/2076-393X/10/9/1394

Internet

https://www.mdpi.com/2076-393X/10/9/1394

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