Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins

Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are evolutionarily conserved machines that couple their folding/assembly to membrane fusion. However, it is unclear how these processes are regulated and function. To determine these mechanisms, we characterized the fold...

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Bibliographic Details
Main Authors: Sylvain Zorman, Aleksander A Rebane, Lu Ma, Guangcan Yang, Matthew A Molski, Jeff Coleman, Frederic Pincet, James E Rothman, Yongli Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-09-01
Series:eLife
Subjects:
SNARE
optical tweezer
protein folding
membrane fusion
SNARE assembly
energy landscape
Online Access:https://elifesciences.org/articles/03348

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