The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
Abstract The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of sufficient quality and breadth for protection....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | Retrovirology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12977-018-0437-y |
| _version_ | 1819040150666084352 |
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| author | Eirini Moysi Constantinos Petrovas Richard A. Koup |
| author_facet | Eirini Moysi Constantinos Petrovas Richard A. Koup |
| author_sort | Eirini Moysi |
| collection | DOAJ |
| description | Abstract The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of sufficient quality and breadth for protection. In this review, we focus on the role of follicular helper CD4 T-cells (Tfh) in the development of such cross-reactive protective antibodies. We discuss germinal center (GC) formation and the dynamics of Tfh and GC B cells during HIV-1/SIV infection and vaccination. Finally, we consider future directions for the study of Tfh and offer perspective on factors that could be modulated to enhance Tfh function in the context of prophylactic vaccination. |
| first_indexed | 2024-12-21T09:04:32Z |
| format | Article |
| id | doaj.art-00145ab25ec344f29f3589383d5f95ce |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-12-21T09:04:32Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-00145ab25ec344f29f3589383d5f95ce2022-12-21T19:09:22ZengBMCRetrovirology1742-46902018-08-0115111010.1186/s12977-018-0437-yThe role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responsesEirini Moysi0Constantinos Petrovas1Richard A. Koup2Immunology Laboratory, Vaccine Research Center, NIAID, NIHImmunology Laboratory, Vaccine Research Center, NIAID, NIHImmunology Laboratory, Vaccine Research Center, NIAID, NIHAbstract The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of sufficient quality and breadth for protection. In this review, we focus on the role of follicular helper CD4 T-cells (Tfh) in the development of such cross-reactive protective antibodies. We discuss germinal center (GC) formation and the dynamics of Tfh and GC B cells during HIV-1/SIV infection and vaccination. Finally, we consider future directions for the study of Tfh and offer perspective on factors that could be modulated to enhance Tfh function in the context of prophylactic vaccination.http://link.springer.com/article/10.1186/s12977-018-0437-yGerminal centerTfhBroadly neutralizing antibodyVaccines |
| spellingShingle | Eirini Moysi Constantinos Petrovas Richard A. Koup The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses Retrovirology Germinal center Tfh Broadly neutralizing antibody Vaccines |
| title | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
| title_full | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
| title_fullStr | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
| title_full_unstemmed | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
| title_short | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
| title_sort | role of follicular helper cd4 t cells in the development of hiv 1 specific broadly neutralizing antibody responses |
| topic | Germinal center Tfh Broadly neutralizing antibody Vaccines |
| url | http://link.springer.com/article/10.1186/s12977-018-0437-y |
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