Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory
Summary: In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, the specific behavioral conditions that lead to circuit disinhibition remain uncertain. To investigate the behavioral relevance of VIP-...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724004431 |
| _version_ | 1797210004915224576 |
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| author | Suhel Tamboli Sanjay Singh Dimitry Topolnik Mohamed El Amine Barkat Risna Radhakrishnan Alexandre Guet-McCreight Lisa Topolnik |
| author_facet | Suhel Tamboli Sanjay Singh Dimitry Topolnik Mohamed El Amine Barkat Risna Radhakrishnan Alexandre Guet-McCreight Lisa Topolnik |
| author_sort | Suhel Tamboli |
| collection | DOAJ |
| description | Summary: In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, the specific behavioral conditions that lead to circuit disinhibition remain uncertain. To investigate the behavioral relevance of VIP-IN activity, we employed wireless technologies allowing us to monitor and manipulate their function in freely behaving mice. Our findings reveal that, during spatial exploration in new environments, VIP-INs in the CA1 hippocampal region become highly active, facilitating the rapid encoding of novel spatial information. Remarkably, both VIP-INs and pyramidal neurons (PNs) exhibit increased activity when encountering novel changes in the environment, including context- and object-related alterations. Concurrently, somatostatin- and parvalbumin-expressing inhibitory populations show an inverse relationship with VIP-IN and PN activity, revealing circuit disinhibition that occurs on a timescale of seconds. Thus, VIP-IN-mediated disinhibition may constitute a crucial element in the rapid encoding of novelty and the acquisition of recognition memory. |
| first_indexed | 2024-04-24T10:03:42Z |
| format | Article |
| id | doaj.art-0014c5e195b04b84a385ab3d1dcc7df4 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-24T10:03:42Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-0014c5e195b04b84a385ab3d1dcc7df42024-04-13T04:21:14ZengElsevierCell Reports2211-12472024-04-01434114115Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memorySuhel Tamboli0Sanjay Singh1Dimitry Topolnik2Mohamed El Amine Barkat3Risna Radhakrishnan4Alexandre Guet-McCreight5Lisa Topolnik6Neuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, CanadaNeuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, CanadaNeuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, CanadaNeuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, CanadaNeuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, CanadaKrembil Centre for Neuroinformatic, University of Toronto, Toronto, ON, CanadaNeuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, Canada; Corresponding authorSummary: In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, the specific behavioral conditions that lead to circuit disinhibition remain uncertain. To investigate the behavioral relevance of VIP-IN activity, we employed wireless technologies allowing us to monitor and manipulate their function in freely behaving mice. Our findings reveal that, during spatial exploration in new environments, VIP-INs in the CA1 hippocampal region become highly active, facilitating the rapid encoding of novel spatial information. Remarkably, both VIP-INs and pyramidal neurons (PNs) exhibit increased activity when encountering novel changes in the environment, including context- and object-related alterations. Concurrently, somatostatin- and parvalbumin-expressing inhibitory populations show an inverse relationship with VIP-IN and PN activity, revealing circuit disinhibition that occurs on a timescale of seconds. Thus, VIP-IN-mediated disinhibition may constitute a crucial element in the rapid encoding of novelty and the acquisition of recognition memory.http://www.sciencedirect.com/science/article/pii/S2211124724004431CP: Neuroscience |
| spellingShingle | Suhel Tamboli Sanjay Singh Dimitry Topolnik Mohamed El Amine Barkat Risna Radhakrishnan Alexandre Guet-McCreight Lisa Topolnik Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory Cell Reports CP: Neuroscience |
| title | Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory |
| title_full | Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory |
| title_fullStr | Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory |
| title_full_unstemmed | Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory |
| title_short | Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory |
| title_sort | mouse hippocampal ca1 vip interneurons detect novelty in the environment and support recognition memory |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724004431 |
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