Mitochondria-Targeted Antioxidant Mito-Tempo Protects Against Aldosterone-Induced Renal Injury In Vivo

Mitochondria-Targeted Antioxidant Mito-Tempo Protects Against Aldosterone-Induced Renal Injury In Vivo

Background/Aims: Growing evidence suggests mitochondrial dysfunction (MtD) and the Nlrp3 inflammasome play critical roles in chronic kidney disease (CKD) progression. We previously reported that Aldosterone (Aldo)-induced renal injury in vitro is directly caused by mitochondrial reactive oxygen spec...

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Bibliographic Details
Main Authors: Wei Ding, Tingyan Liu, Xiao Bi, Zhiling Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Aldosterone
Mitochondrial dysfunction
Nlrp3 inflammasome
Endoplasmic reticulum stress
Mito-Tempo
Online Access:https://www.karger.com/Article/FullText/485287

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